Cd8− T Cell Transfectants That Express a High Affinity T Cell Receptor Exhibit Enhanced Peptide-Dependent Activation

The Immunological Synapse: A Molecular Machine Controlling T Cell Activation

1999 • 3,025 citations

Three-dimensional segregation of supramolecular activation clusters in T cells

1998 • 2,316 citations

Serial triggering of many T-cell receptors by a few peptide–MHC complexes

1995 • 1,143 citations

Kinetic proofreading in T-cell receptor signal transduction.

1995 • 931 citations

LIGAND RECOGNITION BY αβ T CELL RECEPTORS

1998 • 904 citations

Evidence that a Single Peptide–MHC Complex on a Target Cell Can Elicit a Cytolytic T Cell Response

1996 • 684 citations

T-cell-receptor affinity and thymocyte positive selection

1996 • 620 citations

Kinetics of T-cell receptor binding to peptide/I-Ek complexes: correlation of the dissociation rate with T-cell responsiveness.

1994 • 431 citations

A TCR Binds to Antagonist Ligands with Lower Affinities and Faster Dissociation Rates Than to Agonists

1996 • 430 citations

On the Dynamics of TCR:CD3 Complex Cell Surface Expression and Downmodulation

2000 • 364 citations

High- and Low-Potency Ligands with Similar Affinities for the TCR

1998 • 322 citations

Efficient T cell activation requires an optimal dwell-time of interaction between the TCR and the pMHC complex

2001 • 314 citations

Enhanced Antigen-Specific Antitumor Immunity with Altered Peptide Ligands that Stabilize the MHC-Peptide-TCR Complex

2000 • 312 citations

In vitroevolution of a T cell receptor with high affinity for peptide/MHC

2000 • 288 citations

Kinetic discrimination in T-cell activation.

1996 • 286 citations

Critical Role for Cd8 in T Cell Receptor Binding and Activation by Peptide/Major Histocompatibility Complex Multimers

2000 • 281 citations

Kinetics and affinity of reactions between an antigen-specific T cell receptor and peptide-MHC complexes

1994 • 253 citations

T Cell Receptor–MHC Interactions up Close

2001 • 252 citations

Ligand-specific oligomerization of T-cell receptor molecules

1997 • 232 citations

Qualitative and Quantitative Differences in T Cell Receptor Binding of Agonist and Antagonist Ligands

1999 • 226 citations

Increased TCR avidity after T cell activation: a mechanism for sensing low-density antigen.

2001 • 219 citations

A Functional Hot Spot for Antigen Recognition in a Superagonist TCR/MHC Complex

2000 • 204 citations

High-affinity reactions between antigen-specific T-cell receptors and peptides associated with allogeneic and syngeneic major histocompatibility complex class I proteins.

1994 • 200 citations

Derivation of a T cell hybridoma variant deprived of functional T cell receptor α and β chain transcripts reveals a nonfunctional α‐mRNA of BW5147 origin

1989 • 188 citations

Expression of membrane interleukin 1 by fibroblasts transfected with murine pro-interleukin 1 alpha cDNA.

1988 • 171 citations

Requirements for Peptide-induced T Cell Receptor Downregulation on Naive CD8+ T Cells

1997 • 169 citations

Structural Basis of 2C TCR Allorecognition of H-2Ld Peptide Complexes

1998 • 160 citations

αβ T cell receptor interactions with syngeneic and allogeneic ligands: Affinity measurements and crystallization

1997 • 147 citations

Differential transport requirements of HLA and H-2 class I glycoproteins

1989 • 143 citations

Conversion of a T Cell Antagonist into an Agonist by Repairing a Defect in the TCR/Peptide/MHC Interface

2000 • 135 citations

Triggering the TCR Complex Causes the Downregulation of Nonengaged Receptors by a Signal Transduction-Dependent Mechanism

2000 • 122 citations

Killer Cell Immunoglobulin Receptors and T Cell Receptors Bind Peptide-Major Histocompatibility Complex Class I with Distinct Thermodynamic and Kinetic Properties

1999 • 122 citations

Lack of strict correlation of functional sensitization with the apparent affinity of MHC/peptide complexes for the TCR.

1995 • 121 citations

Peptide Antagonism and T Cell Receptor Interactions with Peptide-MHC Complexes

1998 • 118 citations

Deficient Cellular Immunity--Finding and Fixing the Defects

1999 • 106 citations

The law of mass action governs antigen-stimulated cytolytic activity of CD8+ cytotoxic T lymphocytes.

1995 • 106 citations

Correlation Between the Number of T Cell Receptors Required for T Cell Activation and TCR–Ligand Affinity

1996 • 103 citations

A Kinetic Window Constricts the T Cell Receptor Repertoire in the Thymus

2001 • 76 citations

Differences in antigen recognition and cytolytic activity of CD8⁺and CD8⁻T cells that express the same antigen-specific receptor

2001 • 57 citations

The Crystal Structures of Kbm1 and Kbm8 Reveal that Subtle Changes in the Peptide Environment Impact Thermostability and Alloreactivity

2001 • 54 citations

The role of T-cell receptor dimerization in T-cell activation

1999 • 51 citations

Analysis of the Expression of Peptide–Major Histocompatibility Complexes Using High Affinity Soluble Divalent T Cell Receptors

1997 • 40 citations

A residue in the center of peptide QL9 affects binding to both Ld and the T cell receptor.

1996 • 35 citations