Leptin is required for fibrogenic responses induced by thioacetamide in the murine liver

Positional cloning of the mouse obese gene and its human homologue

1994 • 12,975 citations

Serum Immunoreactive-Leptin Concentrations in Normal-Weight and Obese Humans

1996 • 6,254 citations

Leptin and the regulation of body weight in mammals

1998 • 5,366 citations

Leptin levels in human and rodent: Measurement of plasma leptin and ob RNA in obese and weight-reduced subjects

1995 • 3,730 citations

Identification and expression cloning of a leptin receptor, OB-R

1995 • 3,498 citations

Transforming Growth Factor β in Tissue Fibrosis

1994 • 3,055 citations

Evidence That the Diabetes Gene Encodes the Leptin Receptor: Identification of a Mutation in the Leptin Receptor Gene in db/db Mice

1996 • 2,185 citations

Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression

1998 • 2,143 citations

Molecular Regulation of Hepatic Fibrosis, an Integrated Cellular Response to Tissue Injury

2000 • 2,078 citations

Leptin levels reflect body lipid content in mice: Evidence for diet-induced resistance to leptin action

1995 • 1,630 citations

The Cellular Basis of Hepatic Fibrosis -- Mechanisms and Treatment Strategies

1993 • 1,444 citations

Nonadipose tissue production of leptin: Leptin as a novel placenta-derived hormone in humans

1997 • 1,299 citations

The stomach is a source of leptin

1998 • 1,215 citations

Leptin regulates proinflammatory immune responses

1998 • 1,161 citations

Leptin activation of Stat3 in the hypothalamus of wild–type and ob/ob mice but not db/db mice

1996 • 1,097 citations

Phenotypes of Mouse diabetes and Rat fatty Due to Mutations in the OB (Leptin) Receptor

1996 • 1,074 citations

Defective STAT signaling by the leptin receptor in diabetic mice.

1996 • 803 citations

Anatomic localization of alternatively spliced leptin receptors (Ob-R) in mouse brain and other tissues

1997 • 771 citations

Leptin can induce proliferation, differentiation, and functional activation of hemopoietic cells

1996 • 751 citations

Fibrosis in chronic hepatitis C correlates significantly with body mass index and steatosis

1999 • 685 citations

Hepatic expression of mature transforming growth factor beta 1 in transgenic mice results in multiple tissue lesions.

1995 • 668 citations

Excess weight risk factor for alcoholic liver disease

1997 • 633 citations

Novel B219/OB receptor isoforms: Possible role of leptin in hematopoiesis and reproduction

1996 • 629 citations

Human Leptin Stimulates Proliferation and Activation of Human Circulating Monocytes

1999 • 588 citations

Leptin and leptin receptor mRNA and protein expression in the murine fetus and placenta

1997 • 518 citations

Leptin regulates proinflammatory immune responses

1998 • 487 citations

A role for leptin and its cognate receptor in hematopoiesis

1996 • 478 citations

Leptin receptor–mediated signaling regulates hepatic fibrogenesis and remodeling of extracellular matrix in the rat

2002 • 387 citations

The role of TGFβ1 in initiating hepatic stellate cell activation in vivo

1999 • 377 citations

Leptin-deficient (ob/ob) mice are protected from T cell-mediated hepatotoxicity: Role of tumor necrosis factor α and IL-18

2000 • 322 citations

Strain-specific differences in mouse hepatic wound healing are mediated by divergent T helper cytokine responses

1997 • 307 citations

Localization of Leptin Receptor mRNA Splice Variants in Murine Peripheral Tissues by RT-PCR andin SituHybridization

1997 • 300 citations

Leptin deficiency enhances sensitivity to endotoxin-induced lethality

1999 • 287 citations

Leptin Augments Inflammatory and Profibrogenic Responses in the Murine Liver Induced by Hepatotoxic Chemicals

2001 • 285 citations

Hepatic fibrosis, glomerulosclerosis, and a lipodystrophy-like syndrome in PEPCK-TGF-beta1 transgenic mice.

1997 • 281 citations

Nonalcoholic Steatohepatitis

1999 • 213 citations

Altered hepatic lymphocyte subpopulations in obesity-related murine fatty livers: Potential mechanism for sensitization to liver damage

2000 • 191 citations

Leptin Is an Endogenous Protective Protein against the Toxicity Exerted by Tumor Necrosis Factor

1999 • 190 citations

Transdifferentiation of Rat Hepatic Stellate Cells Results in Leptin Expression

1998 • 181 citations

Phenotypic abnormalities in macrophages from leptin-deficient, obese mice

1999 • 166 citations

Gender-dependent alterations in serum leptin in alcoholic cirrhosis

1998 • 150 citations

Leptin Stimulates Fetal and Adult Erythroid and Myeloid Development

1997 • 144 citations

Increased circulating leptin in alcoholic cirrhosis: Relation to release and disposal

1999 • 100 citations

Activated stellate (Ito) cells possess voltage-activated calcium current

1999 • 19 citations