Metformin reverses fatty liver disease in obese, leptin-deficient mice

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

Nonalcoholic fatty liver disease: A spectrum of clinical and pathological severity☆, ☆☆

1999 • 3,339 citations

IRS-1-Mediated Inhibition of Insulin Receptor Tyrosine Kinase Activity in TNF-α- and Obesity-Induced Insulin Resistance

1996 • 2,561 citations

Protection from obesity-induced insulin resistance in mice lacking TNF-α function

1997 • 2,190 citations

Association of nonalcoholic fatty liver disease with insulin resistance

1999 • 1,560 citations

Metabolic Effects of Metformin in Non-Insulin-Dependent Diabetes Mellitus

1995 • 1,135 citations

Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy

1999 • 1,040 citations

Obesity increases sensitivity to endotoxin liver injury: Implications for the pathogenesis of steatohepatitis

1997 • 815 citations

Insulin resistance and diabetes mellitus in transgenic mice expressing nuclear SREBP-1c in adipose tissue: model for congenital generalized lipodystrophy

1998 • 797 citations

Essential role of tumor necrosis factor α in alcohol-induced liver injury in mice

1999 • 704 citations

Increased Levels of Nuclear SREBP-1c Associated with Fatty Livers in Two Mouse Models of Diabetes Mellitus

1999 • 697 citations

Liver Pathology and the Metabolic Syndrome X in Severe Obesity

1999 • 592 citations

Prevalence of chronic liver disease in the general population of northern Italy: The dionysos study

1994 • 533 citations

The OB Protein (Leptin) Pathway - A Link Between Adipose Tissue Mass and Central Neural Networks

1996 • 517 citations

Nonalcoholic Steatohepatitis

1997 • 488 citations

Obesity Induces Expression of Uncoupling Protein-2 in Hepatocytes and Promotes Liver ATP Depletion

1999 • 442 citations

Metabolic effects of metformin on glucose and lactate metabolism in noninsulin-dependent diabetes mellitus.

1996 • 410 citations

Mechanism of Metformin Action in Obese and Lean Noninsulin-Dependent Diabetic Subjects*

1991 • 400 citations

Mitochondrial Adaptations to Obesity-Related Oxidant Stress

2000 • 362 citations

Malonyl-coenzyme-A is a potential mediator of cytotoxicity induced by fatty-acid synthase inhibition in human breast cancer cells and xenografts.

2000 • 362 citations

Expression of fatty acid synthase (FAS) as a predictor of recurrence in stage I breast carcinoma patients

1996 • 311 citations

The Antihyperglycaemic Effect of Metformin

1999 • 299 citations

Circadian transcription of the cholesterol 7 alpha hydroxylase gene may involve the liver-enriched bZIP protein DBP.

1993 • 293 citations

Cytokines and Alcoholic Liver Disease

1993 • 292 citations

Sterol-dependent repression of low density lipoprotein receptor promoter mediated by 16-base pair sequence adjacent to binding site for transcription factor Sp1.

1988 • 271 citations

Obesity and mild hyperinsulinemia found in neuropeptide Y-Y1 receptor-deficient mice

1998 • 217 citations

Acute Antihyperglycemic Mechanisms of Metformin in NIDDM: Evidence for Suppression of Lipid Oxidation and Hepatic Glucose Production

1994 • 217 citations

Cellular mechanisms of insulin resistance in humans

1999 • 176 citations

Lipids up-regulate uncoupling protein 2 expression in rat hepatocytes

1999 • 156 citations

Fatty infiltration of the liver: analysis of prevalence, radiological and clinical features and influence on patient management

1992 • 151 citations

Tumor Necrosis Factor-α Stimulates the Maturation of Sterol Regulatory Element Binding Protein-1 in Human Hepatocytes through the Action of Neutral Sphingomyelinase

1998 • 146 citations

Effect of metformin on food intake in obese subjects

1998 • 139 citations

Tumor necrosis factor-alpha induces c-jun during the regenerative response to liver injury

1994 • 129 citations

Bacterial Lipopolysaccharide Induces Uncoupling Protein-2 Expression in Hepatocytes by a Tumor Necrosis Factor-α-Dependent Mechanism

1998 • 98 citations

Subchronic treatment with metformin produces anorectic effect and reduces hyperinsulinemia in genetically obese zucker rats

1992 • 57 citations

Effects of metformin on glucose, insulin and lipid metabolism in patients with mild hypertriglyceridaemia and non-insulin dependent diabetes by glucose tolerance test criteria.

1991 • 56 citations

Pioglitazone and Metformin Reverse Insulin Resistance Induced by Tumor Necrosis Factor-Alpha in Liver Cells

1997 • 54 citations

Comitogenic effects of estrogens on DNA synthesis induced by various growth factors in cultured female rat hepatocytes

1994 • 42 citations

Antihyperglycemic action of guanidinoalkanoic acids: 3-guanidinopropionic acid ameliorates hyperglycemia in diabetic KKAy and C57BL6Job/ob mice and increases glucose disappearance in rhesus monkeys.

1993 • 41 citations

Dual effect of metformin in cultured rat hepatocytes: Potentiation of insulin action and prevention of insulin-induced resistance

1990 • 37 citations

Neonatal brown adipose tissue, UCPI and the novel uncoupling proteins

1998 • 36 citations

Metformin enhances certain insulin actions in cultured rat hepatoma cells

1988 • 18 citations

The co-mitogenic effects of various estrogens for TGF-α-induced DNA synthesis in cultured female rat hepatocytes

1994 • 10 citations

Metformin induces an agonist-specific increase in albumin production by primary cultured rat hepatocytes

1995 • 8 citations

Metformin and liver glycogen synthase activity in obese Zucker rats.

1993 • 3 citations