Leptin in hepatic fibrosis: Evidence for increased collagen production in stellate cells and lean littermates ofob/obmice

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Short-Term Effects of Nose-Only Cigarette Smoke Exposure on Glutathione Redox Homeostasis, Cytochrome P450 1A1/2 and Respiratory Enzyme Activities in Mice Tissues

2013 • 47,043 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

THE ATTRACTIONS OF PROTEINS FOR SMALL MOLECULES AND IONS

1949 • 19,979 citations

Positional cloning of the mouse obese gene and its human homologue

1994 • 12,975 citations

Effects of the obese Gene Product on Body Weight Regulation in ob / ob Mice

1995 • 4,057 citations

Identification and expression cloning of a leptin receptor, OB-R

1995 • 3,498 citations

Recombinant Mouse OB Protein: Evidence for a Peripheral Signal Linking Adiposity and Central Neural Networks

1995 • 3,302 citations

Picrosirius staining plus polarization microscopy, a specific method for collagen detection in tissue sections

1979 • 2,491 citations

Abnormal splicing of the leptin receptor in diabetic mice

1996 • 2,361 citations

Evidence That the Diabetes Gene Encodes the Leptin Receptor: Identification of a Mutation in the Leptin Receptor Gene in db/db Mice

1996 • 2,185 citations

Molecular Regulation of Hepatic Fibrosis, an Integrated Cellular Response to Tissue Injury

2000 • 2,078 citations

‘The Ideal Mesh?'

2013 • 1,730 citations

Dimerization of cell surface receptors in signal transduction

1995 • 1,631 citations

Cytokine signal transduction

1994 • 1,358 citations

The Leptin Receptor

1997 • 1,300 citations

Leptin activation of Stat3 in the hypothalamus of wild–type and ob/ob mice but not db/db mice

1996 • 1,097 citations

Leptin: The Tale of an Obesity Gene

1996 • 987 citations

The full-length leptin receptor has signaling capabilities of interleukin 6-type cytokine receptors.

1996 • 820 citations

Defective STAT signaling by the leptin receptor in diabetic mice.

1996 • 803 citations

Modulation of Insulin Activities by Leptin

1996 • 733 citations

Leptin induces oxidative stress in human endothelial cells

1999 • 682 citations

Isolation and culture of hepatic lipocytes, Kupffer cells, and sinusoidal endothelial cells by density gradient centrifugation with Stractan

1987 • 359 citations

Cytokines and Fibrogenesis

1999 • 358 citations

Leptin enhances wound re-epithelialization and constitutes a direct function of leptin in skin repair

2000 • 302 citations

Soluble Leptin Receptor Represents the Main Leptin Binding Activity in Human Blood

2001 • 294 citations

Non-alcoholic fatty liver: another feature of the metabolicsyndrome?

1999 • 294 citations

Leptin Augments Inflammatory and Profibrogenic Responses in the Murine Liver Induced by Hepatotoxic Chemicals

2001 • 285 citations

An immortalized rat liver stellate cell line (HSC-T6): a new cell model for the study of retinoid metabolism in vitro

2000 • 282 citations

Molecular Cloning of Rat Leptin Receptor Isoform Complementary DNAs—Identification of a Missense Mutation in Zucker Fatty (fa/fa) Rats

1996 • 264 citations

Cytokines and cellular crosstalk involved in the activation of fat-storing cells.

1995 • 224 citations

Leptin Receptor Action in Hepatic Cells

1997 • 204 citations

Expression of leptin and leptin receptor isoforms in the human stomach

2000 • 192 citations

Leptin Induces Mitogen-activated Protein Kinase- dependent Proliferation of C3H10T1/2 Cells

1997 • 187 citations

Transdifferentiation of Rat Hepatic Stellate Cells Results in Leptin Expression

1998 • 181 citations

Gender-dependent alterations in serum leptin in alcoholic cirrhosis

1998 • 150 citations

Leptin stimulates type I collagen production in db/db mesangial cells: Glucose uptake and TGF-β type II receptor expression

2001 • 143 citations

Vascular Endothelial Growth Factor Activates STAT Proteins in Aortic Endothelial Cells

2000 • 135 citations

Elevation of vitreous leptin in diabetic retinopathy and retinal detachment.

2000 • 63 citations

Acetaldehyde Enhances Murine α₂(I) Collagen Promoter Activity by Ca²⁺‐Independent Protein Kinase C Activation in Cultured Rat Hepatic Stellate Cells

1999 • 35 citations

Effects of acetaldehyde on nuclear protein binding to the nuclear factor I consensus sequence in the α2(I) collagen promoter

1995 • 34 citations

Serum Leptin and Lipid Profiles in Thai Obese and Overweight Subjects

2001 • 10 citations

Clinical Implication of Serial Leptin Measurement in Subjects with Type 2 Diabetes Mellitus.

2001 • 6 citations