Biphenyl-indanone A, a Positive Allosteric Modulator of the Metabotropic Glutamate Receptor Subtype 2, Has Antipsychotic- and Anxiolytic-Like Effects in Mice

PHARMACOLOGY AND FUNCTIONS OF METABOTROPIC GLUTAMATE RECEPTORS

1997 • 3,070 citations

The use of a plus-maze to measure anxiety in the mouse

1987 • 2,571 citations

Metabotropic glutamate receptors as novel targets for anxiety and stress disorders

2005 • 593 citations

The role of amygdala glutamate receptors in fear learning, fear-potentiated startle, and extinction

2002 • 354 citations

A Novel Selective Positive Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 5 Has in Vivo Activity and Antipsychotic-Like Effects in Rat Behavioral Models

2004 • 296 citations

N-desmethylclozapine, an allosteric agonist at muscarinic 1 receptor, potentiates N-methyl- <scp>d</scp> -aspartate receptor activity

2003 • 282 citations

Anxiolytic and side-effect profile of LY354740: a potent, highly selective, orally active agonist for group II metabotropic glutamate receptors.

1998 • 277 citations

Activation of the genetically defined m1 muscarinic receptor potentiates N -methyl- <scp>d</scp> -aspartate (NMDA) receptor currents in hippocampal pyramidal cells

1998 • 275 citations

The metabotropic glutamate 2/3 receptor agonists LY354740 and LY379268 selectively attenuate phencyclidine versus d-amphetamine motor behaviors in rats.

1999 • 266 citations

A selective metabotropic glutamate receptor 7 agonist: Activation of receptor signaling via an allosteric site modulates stress parameters in vivo

2005 • 233 citations

Animal behavior models of the mechanisms underlying antipsychotic atypicality

2003 • 230 citations

Glutamate and anxiety

2004 • 211 citations

LY354740, an mGlu2/3 Receptor Agonist as a Novel Approach to Treat Anxiety/Stress

2003 • 208 citations

Stress-Induced Hyperthermia in Singly Housed Mice

1997 • 193 citations

Differential involvement of group II and group III mGluRs as autoreceptors at lateral and medial perforant path synapses

1996 • 188 citations

Discovery of an Ectopic Activation Site on the M₁Muscarinic Receptor

2002 • 187 citations

Anxiolytic effects of a novel group II metabotropic glutamate receptor agonist (LY354740) in the fear-potentiated startle paradigm in humans

2003 • 187 citations

Discovery of Allosteric Potentiators for the Metabotropic Glutamate 2 Receptor: Synthesis and Subtype Selectivity of N-(4-(2-Methoxyphenoxy)phenyl)-N-(2,2,2− trifluoroethylsulfonyl)pyrid-3-ylmethylamine

2003 • 178 citations

A Selective Allosteric Potentiator of Metabotropic Glutamate (mGlu) 2 Receptors Has Effects Similar to an Orthosteric mGlu2/3 Receptor Agonist in Mouse Models Predictive of Antipsychotic Activity

2005 • 170 citations

Pharmacological Characterization and Identification of Amino Acids Involved in the Positive Modulation of Metabotropic Glutamate Receptor Subtype 2

2003 • 159 citations

Metabotropic glutamate 2 receptor potentiators: receptor modulation, frequency-dependent synaptic activity, and efficacy in preclinical anxiety and psychosis model(s)

2005 • 155 citations

Pharmacological and endocrinological characterisation of stress-induced hyperthermia in singly housed mice using classical and candidate anxiolytics (LY314582, MPEP and NKP608)

2002 • 139 citations

Glutamatergic Animal Models of Schizophrenia

2003 • 139 citations

Protein Kinase C and A₃Adenosine Receptor Activation Inhibit Presynaptic Metabotropic Glutamate Receptor (mGluR) Function and Uncouple mGluRs from GTP-Binding Proteins

1998 • 124 citations

Anxiolytic Activity of the MGLU2/3 Receptor Agonist LY354740 on the Elevated Plus Maze is Associated with the Suppression of Stress-Induced c-Fos in the Hippocampus and Increases in c-Fos Induction in Several Other Stress-Sensitive Brain Regions

2003 • 103 citations

Allosteric Potentiators of Metabotropic Glutamate Receptor Subtype 5 Have Differential Effects on Different Signaling Pathways in Cortical Astrocytes

2005 • 102 citations

The mGlu2/3 receptor agonist LY379268 selectively blocks amphetamine ambulations and rearing

2000 • 91 citations

Functional coupling of the human dopamine D₂ receptor with Gα_i1, Gα_i2, Gα_i3 and Gα_o G proteins: evidence for agonist regulation of G protein selectivity

2003 • 88 citations

Analgesic effects of the selective group II (mGlu2/3) metabotropic glutamate receptor agonists LY379268 and LY389795 in persistent and inflammatory pain models after acute and repeated dosing

2005 • 88 citations

Improved Bioavailability of the mGlu2/3 Receptor Agonist LY354740 Using a Prodrug Strategy: In Vivo Pharmacology of LY544344

2005 • 66 citations

Agonist-directed trafficking of porcine alpha(2A)-adrenergic receptor signaling in Chinese hamster ovary cells: l-isoproterenol selectively activates G(s).

2000 • 64 citations

Metabotropic glutamate 2/3 receptors as drug targets

2003 • 53 citations

Allosteric potentiators of the metabotropic glutamate receptor 2 (mGlu2). Part 3: Identification and biological activity of indanone containing mGlu2 receptor potentiators

2005 • 50 citations

Biphenyl-indanones: Allosteric potentiators of the metabotropic glutamate subtype 2 receptor

2005 • 49 citations

Benzazoles as allosteric potentiators of metabotropic glutamate receptor 2 (mGluR2): Efficacy in an animal model for schizophrenia

2005 • 43 citations

Identification and Initial Structure−Activity Relationships of a Novel Class of Nonpeptide Inhibitors of Blood Coagulation Factor Xa

1998 • 39 citations

(Acylaryloxy)acetic acid diuretics. 1. (2-Alkyl- and 2,2-dialkyl-1-oxo-5-indanyloxy)acetic acids

1977 • 32 citations