Agonist-directed trafficking of porcine alpha(2A)-adrenergic receptor signaling in Chinese hamster ovary cells: l-isoproterenol selectively activates G(s).

A highly sensitive adenylate cyclase assay

1974 • 4,213 citations

Agonist-receptor efficacy II: agonist trafficking of receptor signals

1995 • 637 citations

Effector Pathway-Dependent Relative Efficacy at Serotonin Type 2A and 2C Receptors: Evidence for Agonist-Directed Trafficking of Receptor Stimulus

1998 • 502 citations

Simultaneous coupling of alpha 2-adrenergic receptors to two G-proteins with opposing effects. Subtype-selective coupling of alpha 2C10, alpha 2C4, and alpha 2C2 adrenergic receptors to Gi and Gs.

1992 • 319 citations

Dual Activation and Inhibition of Adenylyl Cyclase by Cannabinoid Receptor Agonists: Evidence for Agonist-Specific Trafficking of Intracellular Responses

1998 • 211 citations

A three-state receptor model of agonist action

1997 • 192 citations

DEPARTMENT of pharmacology.

1951 • 190 citations

Coupling of the alpha 2A-adrenergic receptor to multiple G-proteins. A simple approach for estimating receptor-G-protein coupling efficiency in a transient expression system.

1994 • 150 citations

Contribution of ligand structure to activation of alpha 2-adrenergic receptor subtype coupling to Gs.

1994 • 133 citations

Signal transduction differences between 5-hydroxytryptamine type 2A and type 2C receptor systems.

1994 • 130 citations

Chimeric Mutagenesis of Putative G-protein Coupling Domains of the α2A-Adrenergic Receptor

1996 • 86 citations

G_iActivator Region of α_2A-Adrenergic Receptors: Distinct Basic Residues Mediate G_iversus G_sActivation

1999 • 67 citations

Multiple Gi protein subtypes regulate a single effector mechanism.

1991 • 67 citations

Characterization of a 5‐HT_1B receptor on CHO cells: functional responses in the absence of radioligand binding

1996 • 64 citations

General Theory of Drug-Receptor Interactions

1977 • 64 citations

Tetramine disulfides: a new tool in α-adrenergic pharmacology

1981 • 55 citations

Influence of G Protein Type on Agonist Efficacy

1999 • 53 citations

Effects of the irreversible α-adrenoceptor antagonists phenoxybenzamine and benextramine on the effectiveness of nifedipine in inhibiting α 1- and α 2-adrenoceptor mediated vasoconstriction in pithed rats

1985 • 41 citations

Interaction of the α-adrenoceptor agonist oxymetazoline with serotonin 5-HT1A, 5-HT1B, 5-HT1C and 5-HT1D receptors

1991 • 40 citations

Measurement of agonist efficacy using an α_2A‐adrenoceptor‐G_i1α fusion protein

1997 • 35 citations

Characterization of pigment aggregating α₂‐adrenoceptors of fish melanophores by use of different agonists after partial irreversible receptor inactivation

1989 • 25 citations

Human fat cell alpha-2 adrenoceptors. I. Functional exploration and pharmacological definition with selected alpha-2 agonists and antagonists.

1989 • 22 citations

THE LIMITATIONS OF MOLECULAR PHARMACOLOGY

1971 • 18 citations

Alpha 2-adrenergic receptor turnover in adipose tissue and kidney: irreversible blockade of alpha 2-adrenergic receptors by benextramine.

1987 • 15 citations

G protein dependent alterations in [125I]iodocyanopindolol and�cyanopindolol binding at 5-HT1B binding sites in rat brain membranes

1989 • 11 citations

Efficacy I: a new method for estimating relative efficacy of full agonists via a newly defined efficacy related parameter

1997 • 7 citations

Thiol group may be involved in the irreversible blockade of presynaptic α2-adrenoreceptors by pyrextramine and benextramine in the isolated guinea pig ileum

1986 • 7 citations