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Analgesic effects of the selective group II (mGlu2/3) metabotropic glutamate receptor agonists LY379268 and LY389795 in persistent and inflammatory pain models after acute and repeated dosing

Data up to Jan 2025

Published2005
Citations88
References40

Total Citations Per Year

Abstract

References (40)

Goodman & Gilman's The Pharmacological Basis of Therapeutics

1985 • 7,054 citations

Goodman and Gilman's the Pharmacological Basis of Therapeutics

1986 • 6,964 citations

Quantitative assessment of tactile allodynia in the rat paw

1994 • 6,953 citations

A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia

1988 • 4,963 citations

Cloned Glutamate Receptors

1994 • 3,989 citations

PHARMACOLOGY AND FUNCTIONS OF METABOTROPIC GLUTAMATE RECEPTORS

1997 • 3,070 citations

Simultaneous analysis of families of sigmoidal curves: application to bioassay, radioligand assay, and physiological dose-response curves.

1978 • 2,400 citations

The metabotropic glutamate receptors: Structure and functions

1995 • 2,269 citations

Pharmacological agents acting at subtypes of metabotropic glutamate receptors

1999 • 1,055 citations

Extracellular Amino Acid Concentrations in the Dorsal Spinal Cord of Freely Moving Rats Following Veratridine and Nociceptive Stimulation

1988 • 396 citations

Design, Synthesis, and Pharmacological Characterization of (+)-2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylic Acid (LY354740): A Potent, Selective, and Orally Active Group 2 Metabotropic Glutamate Receptor Agonist Possessing Anticonvulsant and Anxiolytic Properties

1997 • 389 citations

LY341495 is a nanomolar potent and selective antagonist of group II metabotropic glutamate receptors

1998 • 360 citations

Peripheral group I metabotropic glutamate receptors modulate nociception in mice

2001 • 288 citations

Modulation of spinal excitability: co-operation between neurokinin and excitatory amino acid neurotransmitters

1994 • 266 citations

Glutamate Receptors and Nociception

2001 • 243 citations

Pharmacological characterization of 1-aminoindan-1,5-dicarboxylic acid, a potent mGluR1 antagonist.

1997 • 173 citations

The contribution of metabotropic glutamate receptors (mGluRs) to formalin-induced nociception

1996 • 168 citations

A new device for the rapid measurement of impaired motor function in mice

1977 • 168 citations

Metabotropic Glutamate Receptor–Mediated Control of Neurotransmitter Release

1998 • 166 citations

The role of excitatory amino acid receptors and intracellular messengers in persistent nociception after tissue injury in rats

1993 • 164 citations

Metabotropic Glutamate Receptor Involvement in Models of Acute and Persistent Pain: Prospects for the Development of Novel Analgesics

2002 • 153 citations

Sensitization of high mechanothreshold superficial dorsal horn and flexor motor neurones following chemosensitive primary afferent activation

1994 • 142 citations

The utility of excitatory amino acid (EAA) antagonists as analgesic agents. I. Comparison of the antinociceptive activity of various classes of EAA antagonists in mechanical, thermal and chemical nociceptive tests

1994 • 135 citations

Regeneration of periodontal primary afferents of the rat incisor following injury of the inferior alveolar nerve with special reference to neuropeptide Y-like immunoreactive primary afferents

1997 • 131 citations

Comparison of the peripheral and central effects of the opioid agonists loperamide and morphine in the formalin test in rats

2002 • 125 citations

Changes of cutaneous receptive fields of spino-cervical-tract neurones and other dorsal horn neurones by microelectrophoretically administered amino acids

1971 • 119 citations

Group II mGluR receptor agonists are effective in persistent and neuropathic pain models in rats

2002 • 119 citations

Localization of metabotropic glutamate receptors 2/3 on primary afferent axons in the rat

2001 • 112 citations

Groups II and III Metabotropic Glutamate Receptors Differentially Modulate Brief and Prolonged Nociception in Primate STT Cells

2000 • 99 citations

Enhanced expression of metabotropic glutamate receptor 3 messenger RNA in the rat spinal cord during ultraviolet irradiation induced peripheral inflammation

1997 • 89 citations

An intracellular analysis of amino acid induced excitations of deep dorsal horn neurones in the rat spinal cord slice

1988 • 74 citations

Tolerance to the motor impairment, but not to the reversal of PCP-induced motor activities by oral administration of the mGlu2/3 receptor agonist, LY379268

2000 • 61 citations

Modulation of sensory neurone excitatory and inhibitory responses in the ventrobasal thalamus by activation of metabotropic excitatory amino acid receptors

1995 • 61 citations

Synthesis of the Four Isomers of 4-Aminopyrrolidine-2,4-dicarboxylate: Identification of a Potent, Highly Selective, and Systemically-Active Agonist for Metabotropic Glutamate Receptors Negatively Coupled to Adenylate Cyclase

1996 • 57 citations

Selective agonist of group II glutamate metabotropic receptors, LY354740, inhibits tolerance to analgesic effects of morphine in mice

2000 • 44 citations

Systemic pre‐treatment with a group II mGlu agonist, LY379268, reduces hyperalgesia in vivo

2002 • 40 citations

Effects of the I1 imidazoline/ α 2-adrenergic receptor agonist moxonidine in comparison with clonidine in the formalin test in rats

2000 • 34 citations

Expression of metabotropic glutamate receptors mRNA in the thalamus and brainstem of monoarthritic rats

2000 • 31 citations

Up-regulation of metabotropic glutamate receptor 3 mRNA expression in the cerebral cortex of monoarthritic rats

2001 • 30 citations

Antinociceptive effect of a group II metabotropic glutamate receptor antagonist in the thalamus of monoarthritic rats

2000 • 28 citations

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Analgesic effects of the selective group II (mGlu2/3) metabotropic glutamate receptor… (2005) – Neuropharmacology | Metascience Observatory Explorer