Animal behavior models of the mechanisms underlying antipsychotic atypicality

Clozapine for the Treatment-Resistant Schizophrenic

1988 • 4,030 citations

Implications of Normal Brain Development for the Pathogenesis of Schizophrenia

1987 • 3,683 citations

Psychopharmacology: The Fourth Generation of Progress

1995 • 2,920 citations

Human studies of prepulse inhibition of startle: normal subjects, patient groups, and pharmacological studies

2001 • 1,695 citations

Psychopharmacology: The Fourth Generation of Progress

1995 • 1,676 citations

Pharmacological studies of prepulse inhibition models of sensorimotor gating deficits in schizophrenia: a decade in review

2001 • 1,479 citations

Sensorimotor Gating and Schizophrenia

1990 • 1,307 citations

Disorders of attention and perception in early schizophrenia

1961 • 1,198 citations

Neural circuit regulation of prepulse inhibition of startle in the rat: current knowledge and future challenges

2001 • 1,048 citations

Neuropsychopharmacology: The Fifth Generation of Progress

2002 • 990 citations

Neurophysiological evidence for a defect in neuronal mechanisms involved in sensory gating in schizophrenia.

1982 • 888 citations

Neuropsychopharmacology : The Fifth Generation of Progress

2002 • 738 citations

Assessing the Validity of an Animal Model of Deficient Sensorimotor Gating in Schizophrenic Patients

1994 • 702 citations

Ketamine-Induced Exacerbation of Psychotic Symptoms and Cognitive Impairment in Neuroleptic-Free Schizophrenics

1997 • 670 citations

Differential Performance of Acute and Chronic Schizophrenics in a Latent Inhibition Task

1988 • 613 citations

Dopaminergic stimulation disrupts sensorimotor gating in the rat

1988 • 609 citations

Startle response models of sensorimotor gating and habituation deficits in schizophrenia

1990 • 457 citations

Isolation rearing of rats produces a deficit in prepulse inhibition of acoustic startle similar to that in schizophrenia

1993 • 376 citations

Effects of phencyclidine and phencyclidine biologs on sensorimotor gating in the rat*1

1989 • 375 citations

IS IT POSSIBLE TO PREDICT THE CLINICAL EFFECTS OF NEUROLEPTIC DRUGS (MAJOR TRANQUILLIZERS) FROM ANIMAL DATA?I. "NEUROLEPTIC ACTIVITY SPECTRA" FOR RATS.

1965 • 348 citations

Climbing behavior induced by apomorphine in mice: a simple test for the study of dopamine receptors in striatum

1976 • 341 citations

Central dopamine hyperactivity in rats mimics abnormal acoustic startle response in schizophrenics

1986 • 341 citations

Clozapine antagonizes phencyclidine-induced deficits in sensorimotor gating of the startle response.

1994 • 334 citations

Disruption of latent inhibition by acute administration of low doses of amphetamine

1988 • 290 citations

Social Isolation in the Rat Produces Developmentally Specific Deficits in Prepulse Inhibition of the Acoustic Startle Response Without Disrupting Latent Inhibition

1994 • 267 citations

The behavioral pharmacology of olanzapine, a novel "atypical" antipsychotic agent.

1992 • 264 citations

The neural substrates for the motor-activating properties of psychostimulants: A review of recent findings

1986 • 262 citations

Latent inhibition in drug naive schizophrenics: relationship to duration of illness and dopamine D2 binding using SPET

1995 • 251 citations

Phencyclidine-induced stereotyped behaviour and social isolation in rats

1996 • 248 citations

Effects of spiperone, raclopride, SCH 23390 and clozapine on apomorphine inhibition of sensorimotor gating of the startle response in the rat.

1991 • 247 citations

Normalization of Information Processing Deficits in Schizophrenia With Clozapine

1999 • 244 citations

Neurophysiological studies of sensory gating in rats: Effects of amphetamine, phencyclidine, and haloperidol

1986 • 243 citations

Sensorimotor Gating and Thought Disturbance Measured in Close Temporal Proximity in Schizophrenic Patients

1999 • 241 citations

Pharmacological Specificity of Conditioned Avoidance Response Inhibition in Rats: Inhibition by Neuroleptics and Correlation to Dopamine Receptor Blockade

1982 • 238 citations

Agranulocytosis during treatment with clozapine

1977 • 229 citations

Animal Models in Psychopharmacology

1991 • 216 citations

Blockade of phencyclidine-induced hyperlocomotion by olanzapine, clozapine and serotonin receptor subtype selective antagonists in mice

1997 • 216 citations

Normal P50 Suppression in Schizophrenia Patients Treated With Atypical Antipsychotic Medications

2000 • 209 citations

M100907, a Serotonin 5-HT2A Receptor Antagonist and Putative Antipsychotic, Blocks Dizocilpine-Induced Prepulse Inhibition Deficits in Sprague–Dawley and Wistar Rats

1999 • 203 citations

Gating of auditory P50 in schizophrenics: Unique effects of clozapine

1996 • 203 citations

Clozapine Blunts N-Methyl-d-Aspartate Antagonist-Induced Psychosis: A Study with Ketamine

1997 • 197 citations

Latent inhibition in schizophrenia

1996 • 191 citations

Failure of haloperidol to block the effects of phencyclidine and dizocilpine on prepulse inhibition of startle

1991 • 189 citations

Multiple serotonin receptor subtypes modulate prepulse inhibition of the startle response in rats

1994 • 179 citations

Animal Models in Psychopharmacology

1991 • 175 citations

Multiple limbic regions mediate the disruption of prepulse inhibition produced in rats by the noncompetitive NMDA antagonist dizocilpine.

1998 • 165 citations

Multiple Limbic Regions Mediate the Disruption of Prepulse Inhibition Produced in Rats by the Noncompetitive NMDA Antagonist Dizocilpine

1998 • 148 citations

Parametric determinants in pre-stimulus modification of acoustic startle: interaction with ketamine

1991 • 143 citations

Differential effects of classical and newer antipsychotics on the hypermotility induced by two dose levels of d-amphetamine

1995 • 139 citations

Treatment of schizophrenia: A clinical and preclinical evaluation of neuroleptic drugs

1993 • 132 citations

Seroquel, clozapine and chlorpromazine restore sensorimotor gating in ketamine-treated rats

1998 • 131 citations

Reduced latent inhibition in people with schizophrenia: an effect of psychosis or of its treatment

1998 • 128 citations

Effects of atypical antipsychotic agents on social behavior in rodents

1993 • 126 citations

From an animal model of an attentional deficit towards new insights into the pathophysiology of schizophrenia

1992 • 125 citations

Amphetamine-induced disruptions of latent inhibition are reinforcer mediated: implications for animal models of schizophrenic attentional dysfunction

1994 • 124 citations

5-HT modulation of auditory and visual sensorimotor gating: II. Effects of the 5-HT2A antagonist MDL 100,907 on disruption of sound and light prepulse inhibition produced by 5-HT agonists in Wistar rats

1996 • 119 citations

Ontogeny of Isolation Rearing-Induced Deficits in Sensorimotor Gating in Rats

1999 • 113 citations

DOI disrupts prepulse inhibition of startle in rats via 5-HT2A receptors in the ventral pallidum

1997 • 113 citations

Neurochemical and in vivo pharmacological profile of sertindole, a limbic-selective neuroleptic compound

1991 • 113 citations

Seroquel: behavioral effects in conventional and novel tests for atypical antipsychotic drug

1993 • 103 citations

Differential effect of antipsychotics on place navigation of rats in the Morris water maze

1996 • 100 citations

Effects of isolation rearing on startle reactivity, habituation, and prepulse inhibition in male Lewis, Sprague-Dawley, and Fischer F344 rats.

1998 • 99 citations

Dopaminergic and noradrenergic modulation of amphetamine-induced changes in auditory gating

1991 • 96 citations

Phencyclidine-induced deficits in prepulse inhibition of startle are blocked by prazosin, an alpha-1 noradrenergic antagonist.

1997 • 95 citations

Psychopharmacology of prepulse inhibition in mice.

1996 • 94 citations

The paw test: a behavioural paradigm for differentiating between classical and atypical neuroleptic drugs

1987 • 92 citations

Disruption of primate social behavior by d-amphetamine and cocaine: Differential antagonism by antipsychotics

1982 • 88 citations

Muscular rigidity and delineation of a dopamine-specific neostriatal subregion: Tonic EMG activity in rats

1985 • 87 citations

Effects of isolation rearing on startle reactivity, habituation, and prepulse inhibition in male Lewis, Sprague-Dawley, and Fischer F344 rats.

1998 • 87 citations

The selective 5-HT2a receptor antagonist MDL 100,907 counteracts the psychomotor stimulation ensuing manipulations with monoaminergic, glutamatergic or muscarinic neurotransmission in the mouse ? implications for psychosis

1995 • 85 citations

Reversal of phencyclidine-induced prepulse inhibition deficits by clozapine in monkeys

2003 • 84 citations

Rodent data and general hypothesis: antipsychotic action exerted through 5-HT2A receptor antagonism is dependent on increased serotonergic tone

1998 • 83 citations

The role of mesolimbic and nigrostriatal dopamine in latent inhibition as measured with the conditioned taste aversion paradigm

1997 • 69 citations

P50 suppression and prepulse inhibition of the startle reflex in humans: a correlational study

1999 • 68 citations

Prepulse inhibition of the acoustic startle response is disrupted by N-ethyl-3,4-methylenedioxyamphetamine (MDEA) in the rat

1989 • 66 citations

Phencyclidine (PCP)-induced deficits of prepulse inhibition in monkeys

2001 • 61 citations

Mesolimbic dopamine and its control of locomotor activity in rats: differences in pharmacology and light/dark periodicity between the olfactory tubercle and the nucleus accumbens

1986 • 59 citations

Part 1: The Concept of Premorbid Adjustment*

1977 • 59 citations

The PAW test: An animal model for neuroleptic drugs which fulfils the criteria for pharmacological isomorphism

1988 • 58 citations

Disruption of prepulse inhibition and increases in locomotor activity by competitive N-methyl-D-aspartate receptor antagonists in rats.

1999 • 57 citations

Characterization of the Disruptions of Prepulse Inhibition and Habituation of Startle Induced by α-Ethyltryptamine

1997 • 56 citations

Behavioral effects of sertindole, risperidone, clozapine and haloperidol inCebus monkeys

1996 • 54 citations

Effects of the serotonin releasers 3,4-methylenedioxymethamphetamine (MDMA), 4-chloroamphetamine (PCA) and fenfluramine on acoustic and tactile startle reflexes in rats.

1992 • 45 citations

Activity of “Seroquel” (ICI 204,636) in Animal Models for Atypical Properties of Antipsychotics: A Comparison with Clozapine

1996 • 45 citations

Developmental markers of psychiatric disorders as identified by sensorimotor gating

2002 • 40 citations

Sensory Gating in Rats: Lack of Correlation Between Auditory Evoked Potential Gating and Prepulse Inhibition

1999 • 40 citations

Behavioral pharmacology of olanzapine: a novel antipsychotic drug.

1997 • 40 citations

Unexpected potentiation by discriminant benzamide derivatives of stereotyped behaviours elicited by dopamine agonists in mice

1985 • 38 citations

Effects of phencyclidine on prepulse inhibition of acoustic startle response in the macaque

2001 • 36 citations

Chronic treatment with haloperidol diminishes the phencyclidine-induced sensorimotor gating deficit in rats

1998 • 34 citations

The olfactory tubercle as a site of action of neuroleptics with an atypical profile in the paw test: effect of risperidone, prothipendyl, ORG 5222, sertindole and olanzapine

1995 • 31 citations

Effects of LU-111995 in three models of disrupted prepulse inhibition in rats.

1999 • 30 citations

The Effects of M100907 in Pharmacological and Developmental Animal Models of Prepulse Inhibition Deficits in Schizophrenia

1999 • 28 citations

Inhibition of methylphenidate-induced behaviors in rats: differences among neuroleptics.

1993 • 28 citations

Effects of JL13, a pyridobenzoxazepine with potential atypical antipsychotic activity, in animal models for schizophrenia.

2001 • 24 citations

The nucleus accumbens and forelimb muscular rigidity in rats

1988 • 24 citations

Atypical antipsychotics

1999 • 14 citations

The Ethological Analysis of Monkeys in a Social Setting as an Animal Model for Schizophrenia

1991 • 13 citations

Antipsychotic drug effects on the behavior of squirrel monkeys differentially controlled by noxious stimuli

1982 • 10 citations

Simulation models for schizophrenia

2000 • 9 citations

(3,4-Dihydroxyphenylimino)-2-imidazoline (DPI): a stimulant of α-adrenoceptors and dopamine receptors

1984 • 8 citations