N-desmethylclozapine, an allosteric agonist at muscarinic 1 receptor, potentiates N-methyl- <scp>d</scp> -aspartate receptor activity

Clozapine for the Treatment-Resistant Schizophrenic

1988 • 4,030 citations

Classification of typical and atypical antipsychotic drugs on the basis of dopamine D-1, D-2 and serotonin2 pKi values.

1989 • 1,313 citations

The Effects of Clozapine, Risperidone, and Olanzapine on Cognitive Function in Schizophrenia

1999 • 1,012 citations

Allosteric binding sites on cell-surface receptors: novel targets for drug discovery

2002 • 640 citations

Effects of Xanomeline, a Selective Muscarinic Receptor Agonist, on Cognitive Function and Behavioral Symptoms in Alzheimer Disease

1997 • 625 citations

Glutamatergic Mechanisms in Schizophrenia

2002 • 579 citations

Selective cognitive dysfunction in acetylcholine M1 muscarinic receptor mutant mice

2002 • 531 citations

Reduction of suicidality during clozapine treatment of neuroleptic- resistant schizophrenia: impact on risk-benefit assessment

1995 • 446 citations

Dopamine receptor sequences. Therapeutic levels of neuroleptics occupy D2 receptors, clozapine occupies D4.

1992 • 445 citations

Clozapine, Olanzapine, Risperidone, and Haloperidol in the Treatment of Patients With Chronic Schizophrenia and Schizoaffective Disorder

2002 • 410 citations

Hyperactivity and Intact Hippocampus-Dependent Learning in Mice Lacking the M₁Muscarinic Acetylcholine Receptor

2001 • 371 citations

Activation of the genetically defined m1 muscarinic receptor potentiates N -methyl- <scp>d</scp> -aspartate (NMDA) receptor currents in hippocampal pyramidal cells

1998 • 275 citations

Antagonism by antimuscarinic and neuroleptic compounds at the five cloned human muscarinic cholinergic receptors expressed in Chinese hamster ovary cells.

1992 • 271 citations

Hyperactivity, elevated dopaminergic transmission, and response to amphetamine in M1 muscarinic acetylcholine receptor-deficient mice

2001 • 254 citations

Tissue Concentrations of Clozapine and its Metabolites in the Rat

1993 • 226 citations

Positive Cooperativity of Acetylcholine and Other Agonists with Allosteric Ligands on Muscarinic Acetylcholine Receptors

1997 • 222 citations

Discovery of an Ectopic Activation Site on the M₁Muscarinic Receptor

2002 • 187 citations

Clozapine is a potent and selective muscarinic M4 receptor agonist

1994 • 179 citations

Clozapine and haloperidol modulate N-methyl-D-aspartate- and non-N-methyl-D-aspartate receptor-mediated neurotransmission in rat prefrontal cortical neurons in vitro.

1997 • 158 citations

Serum levels of clozapine and norclozapine in patients treated with selective serotonin reuptake inhibitors

1996 • 150 citations

Xanomeline, an M1/M4 preferring muscarinic cholinergic receptor agonist, produces antipsychotic-like activity in rats and mice

2000 • 147 citations

Clozapine and N-desmethylclozapine are potent 5-HT1C receptor antagonists

1993 • 125 citations

Subtype-Selective Positive Cooperative Interactions between Brucine Analogues and Acetylcholine at Muscarinic Receptors: Radioligand Binding Studies

1998 • 118 citations

The muscarinic receptor agonist xanomeline has an antipsychotic-like profile in the rat.

2001 • 114 citations

Treatment-Resistance to Clozapine in Association With Ultrarapid CYP1A2 Activity and the C → A Polymorphism in Intron 1 of the CYP1A2 Gene: Effect of Grapefruit Juice and Low-Dose Fluvoxamine

2001 • 96 citations

Muscarinic m4 receptor activation by some atypical antipsychotic drugs

1997 • 93 citations

Clinical and Neurocognitive Effects of Clozapine and Risperidone in Treatment-Refractory Schizophrenic Patients

1998 • 91 citations

Transmembrane Domains 4 and 7 of the M1Muscarinic Acetylcholine Receptor Are Critical for Ligand Binding and the Receptor Activation Switch

2001 • 84 citations

Scintillation proximity assay of inositol phosphates in cell extracts: High-throughput measurement of G-protein-coupled receptor activation

2003 • 79 citations

Simultaneous determination of clozapine and its N-desmethyl and N-oxide metabolites in plasma by liquid chromatography/electrospray tandem mass spectrometry and its application to plasma level monitoring in schizophrenic patients.

2001 • 68 citations

Alanine-Scanning Mutagenesis of Transmembrane Domain 6 of the M₁Muscarinic Acetylcholine Receptor Suggests that Tyr381 Plays Key Roles in Receptor Function

1999 • 66 citations

Mixed Agonist–Antagonist Properties of Clozapine at Different Human Cloned Muscarinic Receptor Subtypes Expressed in Chinese Hamster Ovary Cells

1999 • 64 citations

Distribution of clozapine and desmethylclozapine between blood and brain in rats

1999 • 61 citations

Delirium: a subcortical phenomenon?

1989 • 60 citations

Effects of clozapine on rat striatal muscarinic receptors coupled to inhibition of adenylyl cyclase activity and on the human cloned m4 receptor

1997 • 50 citations

Effect of scopolamine on the efflux of dopamine and its metabolites after clozapine, haloperidol or thioridazine.

1994 • 44 citations

Current issues in the psychopharmacology of schizophrenia

2001 • 38 citations

Effects of Desmethylclozapine on Fos Protein Expression in the Forebrain: In Vivo Biological Activity of the Clozapine Metabolite

1998 • 26 citations

A Kinetic Model for Simultaneous Fit of Clozapine and Norclozapine Concentrations in Chronic Schizophrenic Patients during Long-Term Treatment

1998 • 21 citations

Inhibition by two lavendustins of the tyrosine kinase activity of pp60F527 in vitro and in intact cells

1994 • 20 citations

DITRAN AND ITS ANTAGONISTS IN A MIXED PSYCHIATRIC POPULATION

1966 • 17 citations