Metabotropic glutamate 2/3 receptors as drug targets

Reversal of Phencyclidine Effects by a Group II Metabotropic Glutamate Receptor Agonist in Rats

1998 • 1,002 citations

The role of excitatory amino acids in behavioral sensitization to psychomotor stimulants

1998 • 936 citations

Unveiling the functions of presynaptic metabotropic glutamate receptors in the central nervous system.

2001 • 678 citations

Effects of Ketamine in Normal and Schizophrenic Volunteers

2001 • 646 citations

Glutamatergic Mechanisms in Schizophrenia

2002 • 579 citations

Distribution of the messenger RNA for a metabotropic glutamate receptor, mGluR2, in the central nervous system of the rat

1993 • 554 citations

Serotonin model of schizophrenia: emerging role of glutamate mechanisms

2000 • 520 citations

Distribution of the mRNA for a metabotropic glutamate receptor (mGluR3) in the rat brain: An in situ hybridization study

1993 • 518 citations

Serotonin Induces Excitatory Postsynaptic Potentials in Apical Dendrites of Neocortical Pyramidal Cells

1997 • 487 citations

Effects of ketamine and n-methyl-d-aspartate on glutamate and dopamine release in the rat prefrontal cortex: modulation by a group II selective metabotropic glutamate receptor agonist LY379268

2003 • 419 citations

The Metabotropic Glutamate Receptors: Structure, Activation Mechanism and Pharmacology

2002 • 288 citations

Anxiolytic and side-effect profile of LY354740: a potent, highly selective, orally active agonist for group II metabotropic glutamate receptors.

1998 • 277 citations

Physiological antagonism between 5-hydroxytryptamine(2A) and group II metabotropic glutamate receptors in prefrontal cortex.

2000 • 275 citations

Distribution of a metabotropic glutamate receptor, mGluR2, in the central nervous system of the rat and mouse: an immunohistochemical study with a monoclonal antibody

1998 • 217 citations

LY354740, an mGlu2/3 Receptor Agonist as a Novel Approach to Treat Anxiety/Stress

2003 • 208 citations

The NMDA Antagonist Model for Schizophrenia: Promise and Pitfalls

1998 • 207 citations

Activation of A1 adenosine or mGlu3 metabotropic glutamate receptors enhances the release of nerve growth factor and S-100? protein from cultured astrocytes

1999 • 193 citations

Anxiolytic effects of a novel group II metabotropic glutamate receptor agonist (LY354740) in the fear-potentiated startle paradigm in humans

2003 • 187 citations

Discovery of Allosteric Potentiators for the Metabotropic Glutamate 2 Receptor: Synthesis and Subtype Selectivity of N-(4-(2-Methoxyphenoxy)phenyl)-N-(2,2,2− trifluoroethylsulfonyl)pyrid-3-ylmethylamine

2003 • 178 citations

Glutamate metabotropic receptors as targets for drug therapy in epilepsy

2003 • 174 citations

Behavioral Evidence for Interactions between a Hallucinogenic Drug and Group II Metabotropic Glutamate Receptors

2000 • 162 citations

Metabotropic Glutamate Receptor Involvement in Models of Acute and Persistent Pain: Prospects for the Development of Novel Analgesics

2002 • 153 citations

Activation of Group II Metabotropic Glutamate Receptors Inhibits Synaptic Excitation of the Substantia Nigra Pars Reticulata

2000 • 139 citations

Potential anti-anxiety, anti-addictive effects of LY 354740, a selective group II glutamate metabotropic receptors agonist in animal models

1999 • 130 citations

Retracted: Neuroprotection mediated by glial group‐II metabotropic glutamate receptors requires the activation of the MAP kinase and the phosphatidylinositol‐3‐kinase pathways

2001 • 125 citations

Group II mGluR receptor agonists are effective in persistent and neuropathic pain models in rats

2002 • 119 citations

LY354740, a potent group II metabotropic glutamate receptor agonist prevents lactate-induced panic-like response in panic-prone rats

2000 • 119 citations

l-Acetylcarnitine Induces Analgesia by Selectively Up-Regulating mGlu2 Metabotropic Glutamate Receptors

2002 • 110 citations

Imipramine and phenelzine decrease glutamate overflow in the prefrontal cortex—a possible mechanism of neuroprotection in major depression?

2000 • 106 citations

Antinociceptive effects following intrathecal pretreatment with selective metabotropic glutamate receptor compounds in a rat model of neuropathic pain

2002 • 104 citations

Preclinical Pharmacology of mGlu2 / 3 Receptor Agonists: Novel Agents for Schizophrenia?

2002 • 102 citations

Group II mGlu receptor agonists inhibit behavioural and electrophysiological effects of DOI in mice

2002 • 97 citations

LY354740, a group II metabotropic glutamate receptor agonist with potential antiparkinsonian properties in rats

1998 • 95 citations

The selective mGlu2/3 receptor agonist LY354740 attenuates morphine-withdrawal-induced activation of locus coeruleus neurons and behavioral signs of morphine withdrawal

1999 • 93 citations

Evaluation of the mGluR2/3 agonist LY379268 in rodent models of Parkinson's disease

2002 • 93 citations

Targeting striatal cholinergic interneurons in Parkinson's disease: Focus on metabotropic glutamate receptors

2003 • 91 citations

Neuroprotective Activity of Metabotropic Glutamate Receptor Ligands

2003 • 86 citations

Metabotropic Glutamate Receptors: Potential Drug Targets for the Treatment of Schizophrenia

2002 • 85 citations

The anxiolytic action of mGlu2/3 receptor agonist, LY354740, in the fear-potentiated startle model in rats is mechanistically distinct from diazepam

2002 • 72 citations

Group II Metabotropic Glutamate Receptor Modulation of DOI-induced c-fos mRNA and Excitatory Responses in the Cerebral Cortex

2003 • 71 citations

Modulation of DOI-induced increases in cortical BDNF expression by group II mGlu receptors

2002 • 67 citations

Protective role of group-II metabotropic glutamate receptors against nigro-striatal degeneration induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in mice

2003 • 67 citations

Anti-epileptic activity of group II metabotropic glutamate receptor agonists (−)-2-oxa-4-aminobicyclo[3.1.0]hexane-4,6-dicarboxylate (LY379268) and (−)-2-thia-4-aminobicyclo[3.1.0]hexane-4,6-dicarboxylate (LY389795)

2001 • 58 citations

The Roles of Metabotropic Glutamate Receptors in Seizures and Epilepsy

2002 • 57 citations

The Group II Metabotropic Glutamate Receptor Agonist (−)-2-Oxa-4-aminobicyclo[3.1.0.]hexane-4,6-dicarboxylate (LY379268) and Clozapine Reverse Phencyclidine-Induced Behaviors in Monoamine-Depleted Rats

2002 • 57 citations

Roles of group II metabotropic glutamate receptors in modulation of seizure activity

2000 • 55 citations

Imipramine treatment up-regulates the expression and function of mGlu2/3 metabotropic glutamate receptors in the rat hippocampus

2002 • 54 citations

The mGlu2/3 receptor agonist LY379268 blocks the expression of locomotor sensitization by amphetamine

2002 • 52 citations

Group II metabotropic glutamate receptors within the amygdala regulate fear as assessed with potentiated startle in rats.

2002 • 49 citations

The selective group mGlu2/3 receptor agonist LY379268 suppresses REM sleep and fast EEG in the rat

2002 • 48 citations

Effects of the mGlu2/3 receptor agonist LY379268 on motor activity in phencyclidine-sensitized rats

2002 • 37 citations

Group II Metabotropic Glutamate Receptors Regulate the Vulnerability to Hypoxic Brain Damage

2003 • 36 citations

Modulation of the Basal Ganglia by Metabotropic Glutamate Receptors: Potential for Novel Therapeutics

2002 • 35 citations

A novel orally active Group 2 metabotropic glutamate receptor agonist

1997 • 26 citations

Glutamatergic mechanisms in antidepressant treatments

2002 • 4 citations