The Structure of the Transition State for Folding of Chymotrypsin Inhibitor 2 Analysed by Protein Engineering Methods: Evidence for a Nucleation-condensation Mechanism for Protein Folding

MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures

1991 • 14,222 citations

A Correlation of Reaction Rates

1955 • 3,425 citations

Are there pathways for protein folding?

1968 • 1,496 citations

Amino Acid Preferences for Specific Locations at the Ends of α Helices

1988 • 1,356 citations

INTERMEDIATES IN THE FOLDING REACTIONS OF SMALL PROTEINS

1990 • 1,133 citations

The folding of an enzyme

1992 • 931 citations

Interior and surface of monomeric proteins

1987 • 924 citations

Folding of chymotrypsin inhibitor 2. 1. Evidence for a two-state transition

1991 • 882 citations

Nucleation, Rapid Folding, and Globular Intrachain Regions in Proteins

1973 • 826 citations

Mapping the transition state and pathway of protein folding by protein engineering

1989 • 699 citations

Protein-folding dynamics

1976 • 626 citations

Kinetics of Protein Folding

1994 • 572 citations

The use of double mutants to detect structural changes in the active site of the tyrosyl-tRNA synthetase (Bacillus stearothermophilus)

1984 • 563 citations

Specific Nucleus as the Transition State for Protein Folding: Evidence from the Lattice Model

1994 • 478 citations

Cooperativity in protein-folding kinetics.

1993 • 470 citations

Optimization of rates of protein folding: the nucleation-condensation mechanism and its implications.

1995 • 467 citations

Transient folding intermediates characterized by protein engineering

1990 • 446 citations

Protein folding dynamics: The diffusion‐collision model and experimental data

1994 • 444 citations

Engineered disulfide bonds as probes of the folding pathway of barnase: Increasing the stability of proteins against the rate of denaturation

1993 • 342 citations

Strategy for analysing the co-operativity of intramolecular interactions in peptides and proteins

1990 • 329 citations

A test of the linear extrapolation of unfolding free energy changes over an extended denaturant concentration range

1992 • 314 citations

Characterizing transition states in protein folding: an essential step in the puzzle

1995 • 308 citations

Crystal and molecular structure of the serine proteinase inhibitor CI-2 from barley seeds

1987 • 260 citations

Effect of cavity-creating mutations in the hydrophobic core of chymotrypsin inhibitor 2

1993 • 256 citations

The folding of an enzyme

1992 • 247 citations

Characterization of the transition state of protein unfolding by use of molecular dynamics: chymotrypsin inhibitor 2.

1994 • 245 citations

Protein folding and stability: the pathway of folding of barnase

1993 • 242 citations

Structure of the transition state for the folding/unfolding of the barley chymotrypsin inhibitor 2 and its implications for mechanisms of protein folding.

1994 • 218 citations

The folding of an enzyme

1992 • 216 citations

Folding of chymotrypsin inhibitor 2. 2. Influence of proline isomerization on the folding kinetics and thermodynamic characterization of the transition state of folding

1991 • 204 citations

Is there a single pathway for the folding of a polypeptide chain?

1985 • 200 citations

Effect of alanine versus glycine in α-helices on protein stability

1992 • 198 citations

Application of physical organic chemistry to engineered mutants of proteins: Hammond postulate behavior in the transition state of protein folding.

1993 • 182 citations

Single versus parallel pathways of protein folding and fractional formation of structure in the transition state.

1994 • 176 citations

Co-operative interactions during protein folding

1992 • 144 citations

Structure of the hydrophobic core in the transition state for folding of chymotrypsin inhibitor 2: A critical test of the protein engineering method of analysis

1993 • 141 citations

Exploring the energy surface of protein folding by structure-reactivity relationships and engineered proteins: Observation of Hammond behavior for the gross structure of the transition state and anti-Hammond behavior for structural elements for unfolding/folding of barnase

1995 • 129 citations

Movement of the position of the transition state in protein folding

1995 • 126 citations

[Stages in the mechanism of self-organization of protein molecules].

1973 • 120 citations

How does protein synthesis give rise to the 3D‐structure?

1991 • 107 citations

Extrapolation to water of kinetic and equilibrium data for the unfolding of barnase in urea solutions

1994 • 78 citations

Molecular Dynamics Simulations of Isolated Helixes of Myoglobin

1995 • 77 citations

Direct observation of better hydration at the N terminus of an alpha-helix with glycine rather than alanine as the N-cap residue.

1994 • 77 citations

Refinement of the three-dimensional solution structure of barley serine proteinase inhibitor 2 and comparison with the structures in crystals

1991 • 69 citations

Folding of a nascent polypeptide chain in vitro: cooperative formation of structure in a protein module.

1995 • 69 citations

Search for Nucleation Sites in Smaller Fragments of Chymotrypsin Inhibitor 2

1995 • 68 citations

Side-Chain Determinants of .beta.-Sheet Stability

1995 • 66 citations

Folding of Barnase in Parts

1994 • 65 citations

Protein anatomy: functional roles of barnase module.

1993 • 48 citations

Protein fragments as models for events in protein folding pathways: Protein engineering analysis of the association of two complementary fragments of the barley chymotrypsin inhibitor 2 (CI-2)

1995 • 44 citations

COSMIC analysis of the major α-helix of barnase during folding

1991 • 42 citations

The structure of the transition state for the association of two fragments of the barley chymotrypsin inhibitor 2 to generate native-like protein: implications for mechanisms of protein folding.

1994 • 38 citations

Contribution of Residues in the Reactive Site Loop of Chymotrypsin Inhibitor 2 to Protein Stability and Activity

1994 • 34 citations

Protein Folding: An unfolding story

1995 • 34 citations

Reassessment of the structure of chymotrypsin inhibitor 2 (CI-2) using time-averaged NMR restraints

1994 • 33 citations

Mutational analysis of the N-capping box of the α-helix of chymotrypsin inhibitor 2

1994 • 31 citations

Structural Studies on Peptides Corresponding to Mutants of the Major .alpha.-Helix of Barnase

1994 • 26 citations