Protein folding and stability: the pathway of folding of barnase

Protein Denaturation

1968 • 2,108 citations

Amino Acid Preferences for Specific Locations at the Ends of α Helices

1988 • 1,356 citations

Hydrogen exchange and structural dynamics of proteins and nucleic acids

1983 • 1,329 citations

INTERMEDIATES IN THE FOLDING REACTIONS OF SMALL PROTEINS

1990 • 1,133 citations

Consideration of the possibility that the slow step in protein denaturation reactions is due to cis-trans isomerism of proline residues

1975 • 1,108 citations

Experimental and Theoretical Aspects of Protein Folding

1975 • 965 citations

Response of a Protein Structure to Cavity-Creating Mutations and Its Relation to the Hydrophobic Effect

1992 • 933 citations

The folding of an enzyme

1992 • 931 citations

Nucleation, Rapid Folding, and Globular Intrachain Regions in Proteins

1973 • 826 citations

Structural characterization of folding intermediates in cytochrome c by H-exchange labelling and proton NMR

1988 • 823 citations

The folding of hen lysozyme involves partially structured intermediates and multiple pathways

1992 • 719 citations

Mapping the transition state and pathway of protein folding by protein engineering

1989 • 699 citations

Helix Signals in Proteins

1988 • 648 citations

NMR evidence for an early framework intermediate on the folding pathway of ribonuclease A

1988 • 583 citations

The use of double mutants to detect structural changes in the active site of the tyrosyl-tRNA synthetase (Bacillus stearothermophilus)

1984 • 563 citations

Protein folding

1990 • 502 citations

NMR Determination of Residual Structure in a Urea-Denatured Protein, the 434-Repressor

1992 • 449 citations

Transient folding intermediates characterized by protein engineering

1990 • 446 citations

Protein folding: local structures, domains, subunits, and assemblies

1991 • 432 citations

The folding of an enzyme

1992 • 376 citations

Estimating the contribution of engineered surface electrostatic interactions to protein stability by using double-mutant cycles

1990 • 350 citations

Redesigning enzyme structure by site-directed mutagenesis: tyrosyl tRNA synthetase and ATP binding

1982 • 348 citations

Aromatic-aromatic interactions and protein stability

1991 • 321 citations

A protein-folding reaction under kinetic control

1992 • 284 citations

Principles of protein stability derived from protein engineering experiments

1993 • 262 citations

The folding of an enzyme

1992 • 247 citations

Dissection of the structure and activity of the tyrosyl-tRNA synthetase by site-directed mutagenesis

1987 • 234 citations

Molecular structure of a new family of ribonucleases

1982 • 222 citations

Early hydrogen-bonding events in the folding reaction of ubiquitin.

1992 • 220 citations

The folding of an enzyme

1992 • 216 citations

Detection and characterization of a folding intermediate in barnase by NMR

1990 • 212 citations

Histidine-aromatic interactions in barnase

1992 • 210 citations

A helix stop signal in the isolated S-peptide of ribonuclease A

1984 • 189 citations

Early folding intermediate of ribonuclease A.

1990 • 180 citations

The folding of an enzyme

1992 • 172 citations

Hydrogen exchange in native and denatured states of hen egg‐white lysozyme

1992 • 168 citations

Structure-activity relationships in engineered proteins: analysis of use of binding energy by linear free energy relationships

1987 • 154 citations

Co-operative interactions during protein folding

1992 • 144 citations

On the interpretation of biochemical data by molecular dynamics computer simulation

1992 • 135 citations

Histidine residues at the N- and C-termini of .alpha.-helixes: perturbed pKas and protein stability

1992 • 122 citations

Determination of the three-dimensional solution structure of barnase using nuclear magnetic resonance spectroscopy

1991 • 122 citations

Superconducting Bi-Ca-Sr-Cu-O Fibers Grown by the Laser-Heated Pedestal Growth Method

1988 • 121 citations

Protein folding kinetics by combined use of rapid mixing techniques and NMR observation of individual amide protons

1986 • 121 citations

Use of binding energy in catalysis analyzed by mutagenesis of the tyrosyl-tRNA synthetase

1986 • 116 citations

An analysis of protein folding pathways

1991 • 116 citations

Folding of staphylococcal nuclease A studied by equilibrium and kinetic circular dichroism spectra

1991 • 115 citations

Mutational analysis of a protein-folding pathway

1989 • 111 citations

Water storage in the mantle

1989 • 103 citations

Effects of the phenylalanine-22 .fwdarw. leucine, glutamic acid-49 .fwdarw. methionine, glycine-234 .fwdarw. aspartic acid and glycine-234 .fwdarw. lysine mutations on the folding and stability of the .alpha. subunit of tryptophan synthase from Escherichia coli

1986 • 99 citations

The folding of an enzyme

1992 • 97 citations

An N-terminal fragment of barnase has residual helical structure similar to that in a refolding intermediate

1992 • 92 citations

Crystal structure of a Barnase-d(GpC) complex at 1.9 Å resolution

1991 • 90 citations

Structural intermediates trapped during the folding of ribonuclease A by amide proton exchange

1980 • 86 citations

Expression of Bacillus amyloliquefaciens extracellular ribonuclease (barnase) in Escherichia coli following an inactivating mutation

1987 • 67 citations

A segment-based approach to protein secondary structure prediction

1992 • 56 citations

Tolerance of T4 lysozyme to proline substitutions within the long interdomain alpha-helix illustrates the adaptability of proteins to potentially destabilizing lesions.

1992 • 53 citations

COSMIC analysis of the major α-helix of barnase during folding

1991 • 42 citations

A violent birth for Mercury

1988 • 22 citations

Chaperone function: cracking the second half of the genetic code

1991 • 21 citations