Exploring the energy surface of protein folding by structure-reactivity relationships and engineered proteins: Observation of Hammond behavior for the gross structure of the transition state and anti-Hammond behavior for structural elements for unfolding/folding of barnase

A Correlation of Reaction Rates

1955 • 3,425 citations

Protein denaturation. C. Theoretical models for the mechanism of denaturation.

1970 • 1,550 citations

The folding of an enzyme

1992 • 931 citations

Mapping the transition state and pathway of protein folding by protein engineering

1989 • 699 citations

Kinetics of Protein Folding

1994 • 572 citations

A primer for the Bema Hapothle. An empirical approach to the characterization of changing transition-state structures

1985 • 544 citations

Transient folding intermediates characterized by protein engineering

1990 • 446 citations

Strength and co-operativity of contributions of surface salt bridges to protein stability

1990 • 415 citations

Capping and α-helix stability

1989 • 363 citations

α-Helix stability in proteins

1992 • 361 citations

Estimating the contribution of engineered surface electrostatic interactions to protein stability by using double-mutant cycles

1990 • 350 citations

Energetics of complementary side chain packing in a protein hydrophobic core

1989 • 346 citations

Engineered disulfide bonds as probes of the folding pathway of barnase: Increasing the stability of proteins against the rate of denaturation

1993 • 342 citations

Aromatic-aromatic interactions and protein stability

1991 • 321 citations

Characterizing transition states in protein folding: an essential step in the puzzle

1995 • 308 citations

The folding of an enzyme

1992 • 247 citations

Protein folding and stability: the pathway of folding of barnase

1993 • 242 citations

Effect of active site residues in barnase on activity and stability

1992 • 231 citations

The folding of an enzyme

1992 • 216 citations

Detection and characterization of a folding intermediate in barnase by NMR

1990 • 212 citations

Effect of alanine versus glycine in α-helices on protein stability

1992 • 198 citations

Application of physical organic chemistry to engineered mutants of proteins: Hammond postulate behavior in the transition state of protein folding.

1993 • 182 citations

The folding of an enzyme

1992 • 172 citations

Relationships between apparent binding energies measured in site-directed mutagenesis experiments and energetics of binding and catalysis

1988 • 172 citations

Circular dichroism studies of barnase and its mutants: Characterization of the contribution of aromatic side chains

1993 • 152 citations

Co-operative interactions during protein folding

1992 • 144 citations

Water storage in the mantle

1989 • 103 citations

The folding of an enzyme

1992 • 97 citations

Extrapolation to water of kinetic and equilibrium data for the unfolding of barnase in urea solutions

1994 • 78 citations

Folding of Barnase in Parts

1994 • 65 citations

COSMIC analysis of the major α-helix of barnase during folding

1991 • 42 citations

Structural Studies on Peptides Corresponding to Mutants of the Major .alpha.-Helix of Barnase

1994 • 26 citations