Mapping the transition state and pathway of protein folding by protein engineering

Enzyme structure and mechanism

1977 • 2,935 citations

Enzyme structure and mechanism

1978 • 2,897 citations

Protein denaturation. C. Theoretical models for the mechanism of denaturation.

1970 • 1,550 citations

Amino Acid Preferences for Specific Locations at the Ends of α Helices

1988 • 1,356 citations

Protein Denaturation

1970 • 1,264 citations

Affinities of amino acid side chains for solvent water

1981 • 846 citations

Structural characterization of folding intermediates in cytochrome c by H-exchange labelling and proton NMR

1988 • 823 citations

Helix Signals in Proteins

1988 • 648 citations

NMR evidence for an early framework intermediate on the folding pathway of ribonuclease A

1988 • 583 citations

Contribution of hydrophobic interactions to protein stability

1988 • 413 citations

Redesigning enzyme structure by site-directed mutagenesis: tyrosyl tRNA synthetase and ATP binding

1982 • 348 citations

Energetics of complementary side chain packing in a protein hydrophobic core

1989 • 346 citations

Dissection of the structure and activity of the tyrosyl-tRNA synthetase by site-directed mutagenesis

1987 • 234 citations

Acid catalysis of the formation of the slow-folding species of RNase A: Evidence that the reaction is proline isomerization

1978 • 229 citations

Molecular structure of a new family of ribonucleases

1982 • 222 citations

Relationships between apparent binding energies measured in site-directed mutagenesis experiments and energetics of binding and catalysis

1988 • 172 citations

Low-temperature unfolding of a mutant of phage T4 lysozyme. 2. Kinetic investigations

1989 • 161 citations

Structure-activity relationships in engineered proteins: analysis of use of binding energy by linear free energy relationships

1987 • 154 citations

Toward a better understanding of protein folding pathways.

1988 • 127 citations

Mutational analysis of a protein-folding pathway

1989 • 111 citations

Effects of the phenylalanine-22 .fwdarw. leucine, glutamic acid-49 .fwdarw. methionine, glycine-234 .fwdarw. aspartic acid and glycine-234 .fwdarw. lysine mutations on the folding and stability of the .alpha. subunit of tryptophan synthase from Escherichia coli

1986 • 99 citations

Effects of multiple replacements at a single position on the folding and stability of dihydrofolate reductase from Escherichia coli

1989 • 70 citations