Hormone-Induced Inositol Lipid Breakdown and Calcium-Mediated Cellular Responses in Liver

A new generation of Ca2+ indicators with greatly improved fluorescence properties.

1985 • 21,873 citations

The role of protein kinase C in cell surface signal transduction and tumour promotion

1984 • 7,521 citations

Inositol trisphosphate, a novel second messenger in cellular signal transduction

1984 • 6,088 citations

Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters.

1982 • 4,786 citations

Inositol trisphosphate and diacylglycerol as second messengers

1984 • 3,535 citations

Release of Ca2+ from a nonmitochondrial intracellular store in pancreatic acinar cells by inositol-1,4,5-trisphosphate

1983 • 2,596 citations

Inositol phospholipids and cell surface receptor function

1975 • 2,458 citations

G proteins and dual control of adenylate cyclase

1984 • 1,811 citations

Calcium channel modulation by neurotransmitters, enzymes and drugs

1983 • 1,267 citations

Rapid accumulation of inositol trisphosphate reveals that agonists hydrolyse polyphosphoinositides instead of phosphatidylinositol

1983 • 1,104 citations

Calcium messenger system: an integrated view.

1984 • 916 citations

Synergistic functions of protein phosphorylation and calcium mobilization in platelet activation.

1983 • 705 citations

Rapid formation of inositol 1,3,4,5-tetrakisphosphate following muscarinic receptor stimulation of rat cerebral cortical slices

1985 • 641 citations

Diacylglycerol and phorbol ester stimulate secretion without raising cytoplasmic free calcium in human platelets

1983 • 589 citations

myo-Inositol 1,4,5-trisphosphate. A second messenger for the hormonal mobilization of intracellular Ca2+ in liver.

1984 • 567 citations

The second messenger linking receptor activation to internal Ca release in liver

1984 • 557 citations

Rapid breakdown of phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate in rat hepatocytes stimulated by vasopressin and other Ca2+-mobilizing hormones

1983 • 547 citations

The stimulation of inositol lipid metabolism that accompanies calcium mobilization in stimulated cells: defined characteristics and unanswered questions

1981 • 518 citations

Evidence that the Rous sarcoma virus transforming gene product phosphorylates phosphatidylinositol and diacylglycerol.

1984 • 476 citations

Involvement of guanine nucleotide-binding protein in the gating of Ca2+ by receptors

1983 • 473 citations

Metabolism of inositol 1,4,5-trisphosphate and inositol 1,3,4-trisphosphate in rat parotid glands

1985 • 450 citations

Phorbol ester and diacylglycerol mimic growth factors in raising cytoplasmic pH

1984 • 447 citations

Inositol trisphosphate and diacylglycerol as intracellular second messengers in liver

1985 • 419 citations

Rapid mobilization of Ca2+ from rat insulinoma microsomes by inositol-1,4,5-trisphosphate

1984 • 410 citations

Growth factors immediately raise cytoplasmic free Ca2+ in human fibroblasts.

1984 • 394 citations

Inositol 1,4,5-trisphosphate releases Ca2+ from intracellular store sites in skinned single cells of porcine coronary artery

1984 • 389 citations

Relationship between inositol polyphosphate production and the increase of cytosolic free Ca2+ induced by vasopressin in isolated hepatocytes.

1984 • 358 citations

Photoreceptor excitation and adaptation by inositol 1,4,5-trisphosphate

1984 • 337 citations

Inositol 1,4,5-trisphosphate: a possible chemical link in excitation-contraction coupling in muscle.

1985 • 330 citations

Stepwise enzymatic dephosphorylation of inositol 1,4,5-trisphosphate to inositol in liver

1984 • 321 citations

Role of calcium in the hormonal regulation of liver metabolism

1981 • 317 citations

Inositol 1,4,5-trisphosphate microinjection activates sea urchin eggs

1984 • 316 citations

myo-inositol polyphosphate may be a messenger for visual excitation in Limulus photoreceptors

1984 • 310 citations

New Perspectives on Calcium Antagonists

1982 • 310 citations

Blockade of the Na+/H+ antiport abolishes growth factor-induced DNA synthesis in fibroblasts. Structure-activity relationships in the amiloride series.

1984 • 305 citations

Inositol trisphosphates in carbachol-stimulated rat parotid glands

1984 • 296 citations

Control of hepatic glycogenolysis.

1980 • 288 citations

Vasopressin-, angiotensin II-, and alpha 1-adrenergic-induced inhibition of Ca2+ transport by rat liver plasma membrane vesicles.

1984 • 279 citations

Transforming protein of avian sarcoma virus UR2 is associated with phosphatidylinositol kinase activity: possible role in tumorigenesis.

1984 • 278 citations

Phorbol ester inhibits phosphoinositide hydrolysis and calcium mobilization in cultured astrocytoma cells.

1985 • 274 citations

Inositol phospholipids in membrane function

1979 • 272 citations

Hormonal regulation of hepatic gluconeogenesis.

1984 • 272 citations

Activation of frog (Xenopus laevis) eggs by inositol trisphosphate. I. Characterization of Ca2+ release from intracellular stores.

1985 • 255 citations

Insulin secretion: Combined effects of phorbol ester and A23187

1983 • 250 citations

Inositol 1,4,5-trisphosphate mimics muscarinic response in Xenopus oocytes

1985 • 249 citations

Molecular mechanisms involved in α-adrenergic responses

1981 • 246 citations

Ca2+ transport by mammalian mitochondria and its role in hormone action

1985 • 242 citations

Inositol 1,4,5-trisphosphate and inositol 1,3,4-trisphosphate formation in Ca2+-mobilizing-hormone-activated cells

1985 • 234 citations

Quantitation and early kinetics of inositol lipid changes induced by vasopressin in isolated and cultured hepatocytes.

1983 • 232 citations

Hydrolysis of polyphosphoinositides by purified sheep seminal vesicle phospholipase C enzymes.

1984 • 225 citations

Mitogens increase phosphorylation of phosphoinositides in thymocytes

1984 • 223 citations

1,2-Diacylglycerol and phorbol ester inhibit agonist-induced formation of inositol phosphates in human platelets: possible implications for negative feedback regulation of inositol phospholipid hydrolysis.

1985 • 222 citations

Intracellular Measurements of Ion Activities

1983 • 221 citations

Protein kinase C and calcium ion in mitogenic response of macrophage-depleted human peripheral lymphocytes.

1985 • 220 citations

Inhibition of hepatic alpha 1-adrenergic effects and binding by phorbol myristate acetate.

1985 • 218 citations

Receptor-Induced Diacylglycerol Formation in Permeabilized Platelets; Possible Role for a Gtp-Binding Protein

1984 • 206 citations

Differential effects of phorbol ester on phenylephrine and vasopressin-induced Ca2+ mobilization in isolated hepatocytes.

1985 • 199 citations

Phorbol esters inhibit the fMet-Leu-Phe- and leukotriene B4-stimulated calcium mobilization and enzyme secretion in rabbit neutrophils.

1985 • 196 citations

Evidence for the role of phosphorylase kinase, protein kinase C, and other Ca2+-sensitive protein kinases in the response of hepatocytes to angiotensin II and vasopressin.

1984 • 192 citations

Diacylglycerol, 1-oleoyl-2-acetyl-glycerol, stimulates superoxide-generation from human neutrophils

1984 • 189 citations

Phorbol esters induce differentiation in a pre-B-lymphocyte cell line by enhancing Na+/H+ exchange.

1984 • 185 citations

The role of calcium ions in the mechanism of action of α-adrenergic agonists in rat liver

1984 • 183 citations

Spermine. A regulator of mitochondrial calcium cycling.

1984 • 181 citations

Phorbol esters inhibit agonist-induced [3H] inositol-1-phosphate accumulation in rat hippocampal slices

1984 • 180 citations

Phospholipids in the nervous system

1982 • 178 citations

Phospholipid Turnover in Hormone Action

1984 • 178 citations

Tumor promoter phorbol 12-myristate, 13-acetate inhibits phosphoinositide hydrolysis and cytosolic Ca2+ rise induced by the activation of muscarinic receptors in PC12 cells

1985 • 176 citations

Aldosterone secretion: Effect of phorbol ester and A23187

1983 • 175 citations

Tumour‐promoting phorbol esters inhibit agonist‐induced phosphatidate formation and Ca²⁺ flux in human platelets

1985 • 173 citations

Oncogenes, ions, and phospholipids

1985 • 171 citations

Serum, platelet-derived growth factor, vasopressin and phorbol esters increase intracellular pH in Swiss 3T3 cells

1983 • 170 citations

Noradrenaline, vasopressin and angiotensin increase Ca2+ influx by opening a common pool of Ca2+ channels in isolated rat liver cells

1984 • 164 citations

Phorbol ester effects on neurotransmission: interaction with neurotransmitters and calcium in smooth muscle.

1985 • 149 citations

Binding sites for inositol trisphosphate in the bovine adrenal cortex

1985 • 145 citations

Determination of the matrix free Ca2+ concentration and kinetics of Ca2+ efflux in liver and heart mitochondria.

1982 • 144 citations

Calcium ion fluxes induced by the action of α-adrenergic agonists in perfused rat liver

1982 • 144 citations

alpha-Adrenergic activation of phosphorylase in liver cells involves mobilization of intracellular calcium without influx of extracellular calcium.

1982 • 143 citations

Characterization of D-myo-inositol 1,4,5-trisphosphate phosphatase in rat liver plasma membranes.

1984 • 131 citations

Regulation of plasma membrane Ca2+ ATPases by lipids of the phosphatidylinositol cycle

1984 • 129 citations

Protein kinases in signal transduction

1984 • 123 citations

Inositol trisphosphate does not release Ca²⁺ from permeabilized cardiac myocytes and sarcoplasmic reticulum

1985 • 123 citations

Phorbol esters rapidly stimulate amiloride-sensitive Na+/H+ exchange in a human leukemic cell line.

1984 • 121 citations

Inositol lipid metabolism in dividing and differentiating cells

1982 • 119 citations

Mechanisms involved in alpha-adrenergic phenomena: role of calcium ions in actions of catecholamines in liver and other tissues

1980 • 118 citations

The role of extracellular Ca2+ in the response of the hepatocyte to Ca2+-dependent hormones.

1985 • 117 citations

Thyrotropin-releasing hormone rapidly activates protein phosphorylation in GH3 pituitary cells by a lipid-linked, protein kinase C-mediated pathway.

1984 • 115 citations

The effect of inositol trisphosphate on Ca2+ fluxes in insulin-secreting tumor cells.

1984 • 104 citations

Phorbol myristate acetate stimulates formation of phosphatidyl inositol 4-phosphate and phosphatidyl inositol 4,5-bisphosphate in human platelets

1984 • 103 citations

Shape change induced in human platelets by platelet-activating factor. Correlation with the formation of phosphatidic acid and phosphorylation of a 40,000-dalton protein.

1983 • 100 citations

12‐O‐Tetradecanoylphorbol 13‐acetate stimulates inositol lipid phosphorylation in intact human platelets

1984 • 99 citations

The origin, quantitation, and kinetics of intracellular calcium mobilization by vasopressin and phenylephrine in hepatocytes.

1983 • 97 citations

Inositol 1,4,5-trisphosphate and the endoplasmic reticulum Ca2+ cycle of a rat insulinoma cell line.

1985 • 89 citations

Studies on the activation of rat liver pyruvate dehydrogenase and 2-oxoglutarate dehydrogenase by adrenaline and glucagon. Role of increases in intramitochondrial Ca2+ concentration

1985 • 84 citations

Regulation of Ca²⁺-Mg²⁺-ATPase Activity in Hepatocyte Plasma Membranes by Vasopressin and Phenylephrine*

1983 • 84 citations

Hormonal Control of Hepatic Gluconeogenesis

1979 • 80 citations

Phorbol ester-induced protein secretion in rat parotid gland. Relationship to the role of inositol lipid breakdown and protein kinase C activation in stimulus-secretion coupling.

1984 • 77 citations

Chronotropic, inotropic, and vasodilator actions of diltiazem, nifedipine, and verapamil. A comparative study of physiological responses and membrane receptor activity.

1983 • 74 citations

Subcellular localization and some properties of the enzymes hydrolysing inositol polyphosphates in rat liver

1985 • 67 citations

Role of inositol lipid breakdown in the generation of intracellular signals. State of the art lecture.

1986 • 60 citations

Effect of phenylephrine on pyruvate dehydrogenase activity in rat hepatocytes and its interaction with insulin and glucagon

1983 • 57 citations

The contribution of both extracellular and intracellular calcium to the action of α-adrenergic agonists in perfused rat liver

1984 • 55 citations

Activation of pyruvate dehydrogenase in the perfused rat liver by vasopressin

1978 • 54 citations

The action of α-adrenergic agonists on plasma-membrane calcium fluxes in perfused rat liver

1984 • 51 citations

Time course of alpha1-adrenergic and vasopressin actions on phosphorylase activation, calcium efflux, pyridine nucleotide reduction, and respiration in hepatocytes.

1983 • 46 citations

Polyphosphoinositide metabolism in excitable membranes

1983 • 44 citations

Decreased flux through pyruvate dehydrogenase during calcium ion movements induced by vasopressin, α-adrenergic agonists and the ionophore A23187 in perfused rat liver

1983 • 37 citations

Determination of mitochondrial calcium content in hepatocytes by a rapid cellular-fractionation technique. α-adrenergic agonists do not mobilize mitochondrial Ca2+

1984 • 29 citations

Stimulated Phosphatidylinositol Turnover A Brief Appraisal

1982 • 26 citations