Receptor-Induced Diacylglycerol Formation in Permeabilized Platelets; Possible Role for a Gtp-Binding Protein

G proteins and dual control of adenylate cyclase

1984 • 1,811 citations

Activation of calcium and phospholipid-dependent protein kinase by diacylglycerol, its possible relation to phosphatidylinositol turnover.

1980 • 1,317 citations

Biochemical Properties of Hormone-Sensitive Adenylate Cyclase

1980 • 1,016 citations

Platelet Sequestration in Man. I. Methods*

1964 • 830 citations

Production of diglyceride from phosphatidylinositol in activated human platelets.

1979 • 727 citations

Synergistic functions of protein phosphorylation and calcium mobilization in platelet activation.

1983 • 705 citations

Rapid breakdown of phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate in rat hepatocytes stimulated by vasopressin and other Ca2+-mobilizing hormones

1983 • 547 citations

Cytoplasmic free Ca²⁺ in human platelets: Ca²⁺ thresholds and Ca‐independent activation for shape‐change and secretion

1982 • 537 citations

Involvement of guanine nucleotide-binding protein in the gating of Ca2+ by receptors

1983 • 473 citations

Thrombin-induced phosphodiesteratic cleavage of phosphatidylinositol bisphosphate in human platelets.

1983 • 394 citations

Guanosine 5'-O-(2-thiodiphosphate). An inhibitor of adenylate cyclase stimulation by guanine nucleotides and fluoride ions.

1979 • 382 citations

Human platelet myosin light chain kinase requires the calcium-binding protein calmodulin for activity.

1979 • 381 citations

A role of calcium-activated phospholipid-dependent protein kinase in human platelet activation. Comparison of thrombin and collagen actions.

1983 • 368 citations

The inhibitory guanine nucleotide-binding regulatory component of adenylate cyclase. Subunit dissociation and guanine nucleotide-dependent hormonal inhibition.

1984 • 345 citations

Phorbol ester-induced activation of human platelets is associated with protein kinase C phosphorylation of myosin light chains

1983 • 265 citations

Studies on apyrases

1961 • 256 citations

Release of diacylglycerol-enriched vesicles from erythrocytes with increased intracellular [Ca2+]

1976 • 244 citations

Guanine nucleotides decrease the free [Ca²⁺] required for secretion of serotonin from permeabilized blood platelets

1984 • 236 citations

Platelet secretion induced by divalent cation ionophores

1974 • 215 citations

Stimulus-response coupling in human platelets. Changes evoked by platelet-activating factor in cytoplasmic free calcium monitored with the fluorescent calcium indicator quin2

1984 • 203 citations

Purification and characterization of the 47,000-dalton protein phosphorylated during degranulation of human platelets.

1983 • 179 citations

Calcium, phospholipid turnover and transmembrane signalling

1983 • 154 citations

Effects of collagen, ionophore A23187 and prostaglandin E1 on the phosphorylation of specific proteins in blood platelets

1979 • 150 citations

Hepatic alpha 1-adrenergic receptors show agonist-specific regulation by guanine nucleotides. Loss of nucleotide effect after adrenalectomy.

1982 • 149 citations

Cyclic nucleotides control a system which regulates Ca2+ sensitivity of platelet secretion

1984 • 147 citations

Potentiation by thrombin of the secretion of serotonin from permeabilized platelets equilibrated with Ca2+ buffers. Relationship to protein phosphorylation and diacylglycerol formation

1984 • 110 citations

Agonist selectivity and second messenger concentration in Ca2+-mediated secretion

1982 • 100 citations

Direct evidence for a role for Ca2+ in amine storage granule secretion by human platelets

1980 • 99 citations

Norepinephrine causes alpha 1-adrenergic receptor-mediated decrease of phosphatidylinositol in isolated rat liver plasma membranes supplemented with cytosol.

1983 • 48 citations

Platelets: Cellular Response Mechanisms and their Biological Significance

1981 • 48 citations

Vasopressin inhibits the adenylate cyclase activity of human platelet particulate fraction through V₁‐receptors

1983 • 42 citations

Ca2+ ionophores and the activation of human blood platelets

1980 • 36 citations

Norepinephrine‐induced loss of phosphatidylinositol from isolated rat liver plasma membrane

1983 • 25 citations

Determination of the Turn‐Off Reaction for the Epinephrine‐Inhibited Human Platelet Adenylate Cyclase

1983 • 25 citations

Protein phosphorylation and diglyceride production during serotonin release induced by epinephrine plus ADP in human platelets

1983 • 17 citations