Neuronal cell death in transmissible spongiform encephalopathies (prion diseases) revisited: from apoptosis to autophagy

Novel Proteinaceous Infectious Particles Cause Scrapie

1982 • 4,972 citations

Autophagy as a Regulated Pathway of Cellular Degradation

2000 • 3,453 citations

Aggresomes, inclusion bodies and protein aggregation

2000 • 1,881 citations

Molecular analysis of prion strain variation and the aetiology of 'new variant' CJD

1996 • 1,740 citations

A cellular gene encodes scrapie PrP 27-30 protein

1985 • 1,494 citations

Prion Diseases of Humans and Animals: Their Causes and Molecular Basis

2001 • 1,307 citations

Identification of a Protein That Purifies with the Scrapie Prion

1982 • 1,260 citations

Toxic Proteins in Neurodegenerative Disease

2002 • 1,202 citations

Nature of the Scrapie Agent: Self-replication and Scrapie

1967 • 1,128 citations

A novel progressive spongiform encephalopathy in cattle

1987 • 1,062 citations

Scrapie prions aggregate to form amyloid-like birefringent rods

1983 • 1,048 citations

Apoptosis and autophagy in nigral neurons of patients with Parkinson's disease.

1997 • 1,016 citations

A protease-resistant protein is a structural component of the Scrapie prion

1983 • 919 citations

Unconventional Viruses and the Origin and Disappearance of Kuru

1977 • 897 citations

Evidence for the Conformation of the Pathologic Isoform of the Prion Protein Enciphering and Propagating Prion Diversity

1996 • 857 citations

Experimental Transmission of a Kuru-like Syndrome to Chimpanzees

1966 • 828 citations

Normal host prion protein necessary for scrapie-induced neurotoxicity

1996 • 791 citations

Creutzfeldt-Jakob Disease (Spongiform Encephalopathy): Transmission to the Chimpanzee

1968 • 778 citations

CHRONIC WASTING DISEASE OF CAPTIVE MULE DEER: A SPONGIFORM ENCEPHALOPATHY

1980 • 760 citations

Neurodegenerative Diseases and Prions

2001 • 755 citations

Depleting Neuronal PrP in Prion Infection Prevents Disease and Reverses Spongiosis

2003 • 728 citations

Does the Agent of Scrapie Replicate without Nucleic Acid ?

1967 • 671 citations

Fatal Familial Insomnia and Dysautonomia with Selective Degeneration of Thalamic Nuclei

1986 • 617 citations

Transmission of the BSE Agent to Mice in the Absence of Detectable Abnormal Prion Protein

1997 • 563 citations

CREUTZFELDT-JAKOB DISEASE VIRUS ISOLATIONS FROM THE GERSTMANN-STRÄUSSLER SYNDROME

1981 • 534 citations

Autophagy in the Eukaryotic Cell

2002 • 534 citations

Huntingtin Expression Stimulates Endosomal–Lysosomal Activity, Endosome Tubulation, and Autophagy

2000 • 522 citations

Antibodies inhibit prion propagation and clear cell cultures of prion infectivity

2001 • 520 citations

The Molecular Mechanism of Autophagy

2003 • 519 citations

Evidence for synthesis of scrapie prion proteins in the endocytic pathway.

1992 • 497 citations

RNA molecules stimulate prion protein conversion

2003 • 494 citations

Identification of scrapie prion protein-specific mRNA in scrapie-infected and uninfected brain

1985 • 490 citations

Abnormal fibrils from scrapie-infected brain

1981 • 473 citations

Diversity in the Mechanisms of Neuronal Cell Death

2003 • 468 citations

Autophagy Is Activated by Apoptotic Signalling in Sympathetic Neurons: An Alternative Mechanism of Death Execution

1999 • 424 citations

Activation of Caspase-3 in Single Neurons and Autophagic Granules of Granulovacuolar Degeneration in Alzheimer's Disease

1999 • 420 citations

Prion biology and diseases.

2004 • 414 citations

Neuropathological Diagnostic Criteria for Creutzfeldt‐Jakob Disease (CJD) and Other Human Spongiform Encephalopathies (Prion Diseases)

1995 • 412 citations

Prion Protein Protects Human Neurons against Bax-mediated Apoptosis

2001 • 374 citations

Molecular classification of sporadic Creutzfeldt–Jakob disease

2003 • 355 citations

Scrapie infectivity, fibrils and low molecular weight protein

1983 • 345 citations

Autophagic and apoptotic types of programmed cell death exhibit different fates of cytoskeletal filaments

2000 • 311 citations

A 'unified theory' of prion propagation

1991 • 304 citations

SPONGIFORM ENCEPHALOPATHY OF ROCKY MOUNTAIN ELK

1982 • 303 citations

Strain-specific prion-protein conformation determined by metal ions

1999 • 292 citations

Glycosylinositol Phospholipid Anchors of the Scrapie and Cellular Prion Proteins Contain Sialic Acid

1992 • 278 citations

Two waves of programmed cell death occur during formation and development of somatic embryos in the gymnosperm, Norway spruce

2000 • 251 citations

Infection-Specific Particle from the Unconventional Slow Virus Diseases

1984 • 214 citations

PrP Deposition, Microglial Activation, and Neuronal Apoptosis in Murine Scrapie

1997 • 195 citations

Biogenesis of Multilamellar Bodies via Autophagy

2000 • 177 citations

Naturally occurring scrapie-like spongiform encephalopathy in five domestic cats

1991 • 176 citations

Nature of the Scrapie Agent

1967 • 172 citations

Introduction to the transmissible spongiform encephalopathies or prion diseases

2003 • 168 citations

Trafficking, turnover and membrane topology of PrP

2003 • 164 citations

Neuronal Apoptosis in Creutzfeldt-Jakob Disease

1999 • 161 citations

Sites of prion protein accumulation in scrapie-infected mouse spleen revealed by immuno-electron microscopy

2000 • 157 citations

Neuronal Cell Death in Scrapie‐Infected Mice Is Due to Apoptosis

1995 • 157 citations

Approaching the Molecular Mechanism of Autophagy

2001 • 155 citations

NEW EMBO MEMBER'S REVIEW: From Alzheimer to Huntington: why is a structural understanding so difficult?

2003 • 148 citations

The Original Gerstmann‐Sträussler‐Scheinker Family of Austria: Divergent Clinicopathological Phenotypes but Constant PrP Genotype

1995 • 137 citations

Molecular cloning of a candidate chicken prion protein.

1992 • 135 citations

Mechanisms of Cell Death in Neurodegenerative Diseases: Fashion, Fiction, and Facts

2002 • 125 citations

A prion-like protein from chicken brain copurifies with an acetylcholine receptor-inducing activity.

1991 • 118 citations

Cell-Free Reconstitution of Microautophagic Vacuole Invagination and Vesicle Formation

2000 • 115 citations

Transmissible Subacute Spongiform Encephalopathies: Prion Diseases

1998 • 111 citations

Prion Protein Peptide Neurotoxicity Can Be Mediated by Astrocytes

1999 • 103 citations

cDNA cloning of turtle prion protein

2000 • 98 citations

Selectivity and Types of Cell Death in the Neuronal Ceroid Lipofuscinoses (NCLs)

2004 • 96 citations

Scrapie-like prion protein accumulates in aggresomes of cyclosporin A-treated cells

2003 • 93 citations

Prion Protein Peptides: Optimal Toxicity and Peptide Blockade of Toxicity

2000 • 93 citations

Detection of apoptosis in murine scrapie

1995 • 90 citations

Detection of apoptosis induced DNA cleavage in scrapie-infected sheep brain

1994 • 87 citations

Conservation of the cellular gene encoding the scrapie prion protein

1986 • 85 citations

Neuronal Apoptosis in Fatal Familial Insomnia

1998 • 84 citations

Microglial expression of the prion protein

1998 • 84 citations

Neuronal autophagy in experimental scrapie

1991 • 81 citations

Astrocytic glutamate uptake and prion protein expression

1999 • 81 citations

Molecular cloning of the cDNA coding for Xenopus laevis prion protein

2001 • 78 citations

Pathology and Immunocytochemistry of a Kuru Brain

1997 • 77 citations

Correlative light and electron microscopy studies of PrP localisation in 87V scrapie

1994 • 74 citations

Spongiform encephalopathy in a captive puma (Felis concolor)

1992 • 73 citations

Morphogenesis of amyloid plaques in 87V murine scrapie†

1994 • 70 citations

Prion-Induced Neuronal Damage — The Mechanisms of Neuronal Destruction in the Subacute Spongiform Encephalopathies

2001 • 69 citations

Neuronal autophagy in experimental Creutzfeldt-Jakob's disease

1989 • 69 citations

Early unsuspected neuron and axon terminal loss in scra pie‐infected mice revealed by morphometry and immunocytochemistry

1995 • 67 citations

Ultrastructural features of spongiform encephalopathy transmitted to mice from three species of bovidae

1992 • 67 citations

Pathology of the transmissible spongiform encephalopathies with special emphasis on ultrastructure

1995 • 66 citations

Deposition patterns of disease-associated prion protein in captive mule deer brains with chronic wasting disease

2001 • 59 citations

Microglia is a component of the prion protein amyloid plaque in the Gerstmann-Str�ussler-Scheinker syndrome

1993 • 57 citations

The physico-chemical nature of the scrapie agent.

1976 • 57 citations

Gerstmann‐Sträussler‐Scheinker disease: Immunohistological and experimental studies

1988 • 55 citations

Astrocytosis and amyloid deposition in scrapie-infected hamsters

1998 • 55 citations

Requirement of a Protein Component for Scrapie Infectivity

1980 • 53 citations

Identification of cDNAs from Japanese pufferfish (Fugu rubripes) and Atlantic salmon (Salmo salar) coding for homologues to tetrapod prion proteins

2003 • 53 citations

A Model for the Mechanism of Astrogliosis in Prion Disease

2000 • 53 citations

Nuclear DNA fragmentation in Creutzfeldt-Jakob disease: does a mere positive in situ nuclear end-labeling indicate apoptosis?

1999 • 51 citations

The natural occurrence of scrapie in moufflon

1992 • 50 citations

Detection of apoptosis in weaver cerebellum by electron microscopic in situ end-labeling of fragmented DNA

1995 • 50 citations

A Nonfibrillar Form of the Fusogenic Prion Protein Fragment [118‐135] Induces Apoptotic Cell Death in Rat Cortical Neurons

2000 • 48 citations

White matter ultrastructural pathology of experimental Creutzfeldt-Jakob disease in mice

1989 • 48 citations

How do neurons degenerate in prion diseases or transmissible spongiform encephalopathies (TSEs): neuronal autophagy revisited

2002 • 44 citations

Cell death in prion disease

1997 • 41 citations

Ultrastructural pathology of prion diseases revisited: brain biopsy studies

2004 • 41 citations

Apoptosis and dendritic dysfunction precede prion protein accumulation in 87V scrapie

2001 • 40 citations

Kuru: Forty Years Later, A Historical Note

1997 • 39 citations

Tyrosine Iminoxyl Radical Formation from Tyrosyl Radical/Nitric Oxide and Nitrosotyrosine

2001 • 39 citations

What is the basis of transmissible spongiform encephalopathy induced neurodegeneration and can it be repaired?

2002 • 34 citations

Prion protein-overexpressing cells show altered response to a neurotoxic prion protein peptide

1998 • 34 citations

Spongiform encephalopathy in an eland.

1990 • 34 citations

Serial ultrastructural studies of scrapie in hamsters

1989 • 32 citations

Transmissible spongiform encephalopathy in greater kudu (Tragelaphus strepsiceros)

1993 • 31 citations

Scrapie-like encephalopathy in a greater kudu (Tragelaphus strepsiceros) which had not been fed ruminant-derived protein

1992 • 28 citations

Neuronal autophagic vacuoles in experimental scrapie and Creutzfeldt-Jakob disease

1992 • 28 citations

Ultrastructural pathology of axons and myelin in experimental scrapie in hamsters and bovine spongiform encephalopathy in cattle and a comparison with the panencephalopathic type of Creutzfeldt-Jakob disease

1992 • 27 citations

Apoptosis in relation to neuronal loss in experimental Creutzfeldt-Jakob disease in mice

2001 • 27 citations

Scrapie inoculation of mice: light and electron microscopy of the superior colliculi

1991 • 25 citations

Ultra Structural Pathology of Gerstmann-Sträussler-Scheinker Disease

1995 • 23 citations

Programmed cell death (apoptosis) in Alzheimer's disease and Creutzfeldt-Jakob disease.

1997 • 23 citations

Mapping the parameters of prion-induced neuropathology

2000 • 20 citations

Nuclear DNA Fragmentation and Immune Reactivity in Bovine Spongiform Encephalopathy

1999 • 20 citations

Prion Diseases: a dual view of the prion hypothesis as seen from a distance

2002 • 18 citations

The Echigo-1: a panencephalopathic strain of Creutzfeldt-Jakob disease: a passage to hamsters and ultrastructural studies.

1997 • 18 citations

SCRAPIE : AN INFECTIVE PEPTIDE ?

1972 • 18 citations

Neuronal loss and apoptosis in experimental Creutzfeldt-Jakob disease in mice.

1999 • 17 citations

A Creutzfeldt‐Jakob disease agent (Echigo‐1 strain) recovered from brain tissue showing the 'panencephalopathic type' disease

1989 • 17 citations

Real-time observation of autophagic programmed cell death of Drosophila salivary glands in vitro

2004 • 14 citations

The phantasmagoric immunology of transmissible spongiform encephalopathy.

1990 • 13 citations

Lesions akin to transmissible spongiform encephalopathy in the brains of rats inoculated with immature cerebellum

1988 • 6 citations

Neuronal Degeneration and Cell Death in Prion Disease

1998 • 5 citations

Deleted Work

1955 • 0 citations