Intracellular localization of human DNA repair enzyme methylguanine-DNA methyltransferase by antibodies and its importance.

A Laboratory manual

1989 • 6,833 citations

[6] Use of T7 RNA polymerase to direct expression of cloned genes

1990 • 6,681 citations

p53 mutations in colorectal cancer.

1990 • 1,030 citations

Possible Relevance of O–6 Alkylation of Deoxyguanosine to the Mutagenicity and Carcinogenicity of Nitrosamines and Nitrosamides

1969 • 949 citations

Direct mutagenesis of Ha-ras-1 oncogenes by N-nitroso-N-methylurea during initiation of mammary carcinogenesis in rats

1985 • 829 citations

Mammalian O6-alkylguanine-DNA alkyltransferase: regulation and importance in response to alkylating carcinogenic and therapeutic agents.

1990 • 736 citations

REGULATION AND EXPRESSION OF THE ADAPTIVE RESPONSE TO ALKYLATING AGENTS

1988 • 645 citations

Protein Import into the Cell Nucleus

1986 • 544 citations

A presumed DNA helicase encoded by ERCC-3 is involved in the human repair disorders xeroderma pigmentosum and Cockayne's syndrome

1990 • 440 citations

Isolation and structural characterization of a cDNA clone encoding the human DNA repair protein for O6-alkylguanine.

1990 • 292 citations

Comparison of O⁶-alkylguanine-DNA alkyltransferase activity based on cellular DNA content in human, rat and mouse tissues

1986 • 277 citations

DNA synthesis with methylated poly(dC-dG) templates. Evidence for a competitive nature to miscoding by

1979 • 247 citations

The role of O6-methylguanine-DNA methyltransferase in cell survival, mutagenesis and carcinogenesis

1985 • 224 citations

Characterisation and nucleotide sequence ofogt, the O⁶-alkyiguanine-DNA-alkyltransferase gene ofE.coli

1987 • 163 citations

Nuclear location signal-mediated protein transport

1989 • 144 citations

Inducibility of the DNA Repair Gene Encoding O⁶-Methylguanine- DNA Methyltransferase in Mammalian Cells by DNA-Damaging Treatments

1991 • 138 citations

Cross-linking of DNA induced by chloroethyinitrosourea is prevented by O⁶-methyiguanine-DNA methyttransferase

1983 • 137 citations

Suppression of human DNA alkylation-repair defects by Escherichia coli DNA-repair genes.

1986 • 115 citations

Molecular cloning of a gene which regulates the adaptive response to alkylating agents in Escherichia coli

1983 • 110 citations

Removal of O6-methylguanine from DNA by human liver fractions.

1982 • 102 citations

Primary sequence and biological functions of a Saccharomyces cerevisiae O6-methylguanine/O4-methylthymine DNA repair methyltransferase gene.

1991 • 94 citations

Cell-specific differences in O6-alkylguanine DNA repair activity during continuous exposure to carcinogen.

1982 • 84 citations

Complementation of sensitivity to alkylating agents in Escherichia coli and Chinese hamster ovary cells by expression of a cloned bacterial DNA repair gene.

1986 • 82 citations

Expression of the O6-methylguanine-DNA methyltransferase gene MGMT in MER+ and MER- human tumor cells.

1990 • 71 citations

Repair of O⁶-methylguanine, O⁶-ethylguanine, O⁶-isopropylguanine, and O⁴-methylthymine in synthetic oligodeoxynucleotides by Escherichia coli ada gene O⁶-alkylguanine-DNA-alkyltransferase

1989 • 71 citations

Transfer of the E. coli O6-methyltransferase gene into repair-deficient human cells and restoration of cellular resistance to N-methyl-N′-nitro-N-nitrosoguanidine

1986 • 67 citations

Cell specific differences in O⁶-methylguanine-DNA methyltransferase activity and removal of O⁶-methylguanine in rat pulmonary cells

1988 • 61 citations

Direct Correlation Between Methylation Status and Expression of the Human O-6-MethyIguanine DNA Methyltransferase Gene

1991 • 58 citations

Cellular Aspects of Dna Repair

1985 • 52 citations

Increase in nitrosourea resistance in mammalian cells by retrovirally mediated gene transfer of bacterial O6-alkylguanine-DNA alkyltransferase.

1989 • 47 citations

Expression of the truncated E. coliO6-methylguanine methyltransferase gene in repair-deficient human cells and restoration of cellular resistance to alkylating agents

1987 • 29 citations

Properties of N-methyl-N-nitrosourea-resistant, Mex- derivatives of an SV40-immortalized human fibroblast cell line

1989 • 28 citations

cDNA cloning of the rat O6-methylguanine-DNA-methyltransferase

1991 • 24 citations

Production of antibodies to peptide sequences present in human O⁶-alkylguanine-DNA alkyltransferase and their use to detect this protein in cell extracts

1991 • 22 citations

Characterization of cDNA encoding mouse DNA repair protein O6-methylguanine-DNA methyltransferase and high-level expression of the wild-type and mutant proteins in E. coli

1992 • 20 citations

Rapid, large-scale purification and characterization of ‘Ada protein’ (0⁶methylguanine-DNA methyltransferase) ofE.coli

1988 • 18 citations

Production and characterization of antipeptide antibodies against human O6-methylguanine-DNA methyltransferase.

1991 • 18 citations

Presence of O6-Methylguanine acceptor protein in the tissues of different classes of vertevrates abd invertebrates

1986 • 11 citations

Expression of O⁶-Alkylguanine-DNA Alkyltransferase in Mer⁺ and Mer^- Human Cell Extracts Probed with Specific Monoclonal Antibodies

1989 • 9 citations