Complementation of sensitivity to alkylating agents in Escherichia coli and Chinese hamster ovary cells by expression of a cloned bacterial DNA repair gene.

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

Short-Term Effects of Nose-Only Cigarette Smoke Exposure on Glutathione Redox Homeostasis, Cytochrome P450 1A1/2 and Respiratory Enzyme Activities in Mice Tissues

2013 • 47,043 citations

Molecular Cloning. A Laboratory Manual

1983 • 27,328 citations

Transformation of mammalian cells with genes from procaryotes and eucaryotes

1979 • 1,474 citations

Selection for animal cells that express the Escherichia coli gene coding for xanthine-guanine phosphoribosyltransferase.

1981 • 1,048 citations

Expression of a Bacterial Gene in Mammalian Cells

1980 • 788 citations

INDUCIBLE DNA REPAIR SYSTEMS

1985 • 586 citations

In vivo mutagenesis by O6-methylguanine built into a unique site in a viral genome.

1984 • 437 citations

Defective repair of alkylated DNA by human tumour and SV40-transformed human cell strains

1980 • 371 citations

Induction of a DNA glycosylase for N-methylated purines is part of the adaptive response to alkylating agents

1982 • 287 citations

Some chemical aspects of dose-response relationships in alkylation mutagenesis

1974 • 284 citations

Adaptation to alkylation resistance involves the induction of a DNA glycosylase

1982 • 283 citations

Adaptive response to alkylating agents involves alteration in situ of O6-methylguanine residues in DNA

1979 • 260 citations

Mutagenicity of carcinogenic methylating agents is associated with a specific DNA modification

1980 • 234 citations

Inducible repair of O-alkylated DNA pyrimidines in Escherichia coli.

1984 • 223 citations

The intracellular signal for induction of resistance to alkylating agents in E. coli

1986 • 222 citations

Active site and complete sequence of the suicidal methyltransferase that counters alkylation mutagenesis.

1985 • 221 citations

Removal of O6-methylguanine from DNA of normal and xeroderma pigmentosum-derived lymphoblastoid lines

1981 • 183 citations

Induction of resistance to alkylating agents in E. coli: the ada+ gene product serves both as a regulatory protein and as an enzyme for repair of mutagenic damage.

1984 • 162 citations

Isolation and characterization of Escherichia coli K-12 mutants unable to induce the adaptive response to simple alkylating agents

1979 • 160 citations

Repair of O⁶-methylguanine in DNA by demethylation is lacking in Mer⁻ human tumor cell strains

1983 • 140 citations

Methyl phosphotriesters in alkylated DNA are repaired by the Ada regulatory protein ofE. coli

1985 • 139 citations

Base-pairing properties of O6-methylguanine in template DNA during in vitro DNA replication.

1984 • 133 citations

O6-Methylguanine-DNA methyltransferase of human lymphoid cells: structural and kinetic properties and absence in repair-deficient cells.

1983 • 125 citations

Site-specific mutagenesis in vivo by single methylated or deaminated purine bases

1986 • 118 citations

Suppression of human DNA alkylation-repair defects by Escherichia coli DNA-repair genes.

1986 • 115 citations

Molecular cloning of a gene which regulates the adaptive response to alkylating agents in Escherichia coli

1983 • 110 citations

Isolation of mutants of Escherichia coli with increased resistance to alkylating agents: Mutants deficient in thiols and mutants constitutive for the adaptive response

1980 • 95 citations

Structure of mutant alleles at the aprt locus of Chinese hamster ovary cells

1983 • 94 citations

High-frequency nonrandom mutational event at the adenine phosphoribosyltransferase (aprt) locus of sib-selected CHO variants heterozygous foraprt

1982 • 87 citations

Role of deoxynucleoside triphosphate pools in the cytotoxic and mutagenic effects of DNA alkylating agents

1981 • 84 citations

Transfer of the E. coli O6-methyltransferase gene into repair-deficient human cells and restoration of cellular resistance to N-methyl-N′-nitro-N-nitrosoguanidine

1986 • 67 citations

Molecular cloning and characterization of the alkB gene of Escherichia coli

1985 • 66 citations

HeLa cell variants that differ in sensitivity to monofunctional alkylating agents, with independence of cytotoxic and mutagenic responses

1979 • 65 citations

Efficient Constitutive Production of Human Fibroblast Interferon by Hamster Cells Transformed with the IFN-β₁Gene Fused to An SV40 Early Promoter

1984 • 52 citations

The cytotoxic and mutagenic effects of alkylating agents on human lymphoid cells are caused by different DNA lesions

1985 • 51 citations

Specifically alkylated DNA fragments. Synthesis and Physical Characterization of D[cGC(o²Me)GCG]and d[cGT(O⁶Me) GCG]

1983 • 51 citations

Possible depletion of a DNA repair enzyme in human lymphoma cells by subversive repair.

1985 • 44 citations

DNA phosphotriesters as indicators of cumulative carcinogen-induced damage

1978 • 36 citations

Depletion of O⁶-methylguanine-DNA-methyltransferase in human fibroblasts increases the mutagenic response to N-methyl-N'-nitro-N-nitrosoguanidine

1985 • 34 citations

Postreplication repair and the susceptibility of Chinese hamster cells to cytotoxic and mutagenic effects of alkylating agents.

1980 • 10 citations