Cellular and molecular mechanisms of IFN-γ production induced by IL-2 and IL-12 in a human NK cell line

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1987 • 3,773 citations

The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C

1991 • 2,499 citations

Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes.

1989 • 1,989 citations

Production of natural killer cell stimulatory factor (interleukin 12) by peripheral blood mononuclear cells.

1992 • 1,168 citations

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1991 • 976 citations

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1993 • 967 citations

Interleukin-12 and its role in the generation of TH1 cells

1993 • 869 citations

Interleukin 12 is required for the T-lymphocyte-independent induction of interferon gamma by an intracellular parasite and induces resistance in T-cell-deficient hosts.

1993 • 837 citations

Recombinant IL-12 administration induces tumor regression in association with IFN-gamma production.

1994 • 796 citations

Interleukin 12 and tumor necrosis factor alpha are costimulators of interferon gamma production by natural killer cells in severe combined immunodeficiency mice with listeriosis, and interleukin 10 is a physiologic antagonist.

1993 • 792 citations

The IL-2/IL-2 receptor system: A current overview

1993 • 778 citations

The Adjuvant Effect of Interleukin-12 in a Vaccine Against Leishmania major

1994 • 687 citations

Involvement of the Jak-3 Janus kinase in signalling by interleukins 2 and 4 in lymphoid and myeloid cells

1994 • 618 citations

Phosphorylation and activation of the Jak-3 Janus kinase in response to interleukin-2

1994 • 598 citations

IL-12: Initiation Cytokine for Cell-Mediated Immunity

1993 • 583 citations

NF-ATp: a transcription factor required for the co-ordinate induction of several cytokine genes

1994 • 523 citations

The same inducible nuclear proteins regulates mitogen activation of both the interleukin-2 receptor-alpha gene and type 1 HIV

1988 • 427 citations

Interleukin 12 (IL-12) induces tyrosine phosphorylation of JAK2 and TYK2: differential use of Janus family tyrosine kinases by IL-2 and IL-12.

1995 • 350 citations

[28] Use and specificity of staurosporine, UCN-O1, and calphostin C as protein kinase inhibitors

1991 • 338 citations

T helper type 1 development of naive CD4⁺ T cells requires the coordinate action of interleukin‐12 and interferon‐γ and is inhibited by transforming growth factor‐β

1994 • 288 citations

Mechanisms of IFN-gamma induction by natural killer cell stimulatory factor (NKSF/IL-12). Role of transcription and mRNA stability in the synergistic interaction between NKSF and IL-2.

1992 • 284 citations

Interleukin-2 induces proliferation of T lymphocyte mutants lacking protein kinase C

1988 • 137 citations

The c-rel protooncogene product c-Rel but not NF-kappa B binds to the intronic region of the human interferon-gamma gene at a site related to an interferon-stimulable response element.

1992 • 134 citations

Cell surface phenotype of a cloned line of human natural killer cells.

1982 • 124 citations

IL-2-induced signal transduction involves the activation of nuclear NF-kappa B expression.

1992 • 89 citations

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1992 • 87 citations

Differential Effects of IL12 and IL2 on Expression and Function of Cellular Adhesion Molecules on Purified Human Natural Killer Cells

1993 • 81 citations

Regulation of CD69 expression on human natural killer cells: differential involvement of protein kinase C and protein tyrosine kinases

1993 • 79 citations

IL-12 Holds Promise Against Cancer, Glimmer of AIDS Hope

1994 • 25 citations

Selective Modulation of IFN-γ mRNA Stability by IL-12/NKSF

1994 • 22 citations

Changes in gene expression associated with IFN-beta and IL-2-induced augmentation of human natural killer cell function.

1988 • 20 citations

Induction of Multiple Cytokine Gene Expression and IRF-1 mRNA by Flavone Acetic Acid in a Murine Macrophage Cell Line

1994 • 8 citations