Suppression of lymphokine-activated killer (LAK) cell induction mediated by interleukin-4 and transforming growth factor-β1: effect of addition of exogenous tumour necrosis factor-alpha and interferon-gamma, and measurement of their endogenous production

Isolation of mononuclear cells and granulocytes from human blood.

1968 • 9,672 citations

Human chronic myelogenous leukemia cell-line with positive Philadelphia chromosome

1975 • 2,865 citations

Human chronic myelogenous leukemia cell-line with positive Philadelphia chromosome

1975 • 2,228 citations

Lymphokine-activated killer cell phenomenon. Lysis of natural killer-resistant fresh solid tumor cells by interleukin 2-activated autologous human peripheral blood lymphocytes.

1982 • 2,228 citations

Transforming growth factor beta

2011 • 1,990 citations

Production of transforming growth factor beta by human T lymphocytes and its potential role in the regulation of T cell growth.

1986 • 1,617 citations

Recombinant Human Tumor Necrosis Factor-α: Effects on Proliferation of Normal and Transformed Cells in Vitro

1985 • 1,596 citations

Classification of human colorectal adenocarcinoma cell lines.

1976 • 943 citations

Transforming Growth Factor‐β

1990 • 696 citations

Effects of transforming growth factor beta on the functions of natural killer cells: depressed cytolytic activity and blunting of interferon responsiveness.

1986 • 579 citations

Distribution and modulation of the cellular receptor for transforming growth factor-beta.

1987 • 556 citations

Interleukin 2-mediated immune interferon (IFN-gamma) production by human T cells and T cell subsets.

1983 • 483 citations

The IL-2 Receptor β Chain (p70): Role in Mediating Signals for LAK, NK, and Proliferative Activities

1987 • 444 citations

Lymphokine-activated killer cells. Analysis of progenitors and effectors.

1986 • 403 citations

Transforming growth factor-beta is a potent immunosuppressive agent that inhibits IL-1-dependent lymphocyte proliferation.

1988 • 392 citations

Transforming Growth Factor β

1988 • 295 citations

IL-4 inhibits the synthesis of IFN-gamma and induces the synthesis of IgE in human mixed lymphocyte cultures.

1990 • 262 citations

Immunotherapy of cancer using interleukin 2: current status and future prospects

1988 • 256 citations

Tumor necrosis factor-alpha enhances cytolytic activity of human natural killer cells.

1987 • 235 citations

Generation of activated killer (AK) cells by recombinant interleukin 2 (rIL 2) in collaboration with interferon-gamma (IFN-gamma).

1985 • 184 citations

Synergy of tumor necrosis factor and interleukin 2 in the activation of human cytotoxic lymphocytes: effect of tumor necrosis factor alpha and interleukin 2 in the generation of human lymphokine-activated killer cell cytotoxicity.

1988 • 172 citations

Transforming growth factor-beta 1 (TGF-beta 1) and recombinant human tumor necrosis factor-alpha reciprocally regulate the generation of lymphokine-activated killer cell activity. Comparison between natural porcine platelet-derived TGF-beta 1 and TGF-beta 2, and recombinant human TGF-beta 1.

1988 • 168 citations

Interleukin 2-activated human killer cells are derived from phenotypically heterogeneous precursors.

1986 • 166 citations

Transforming growth factor-beta inhibits the in vitro generation of lymphokine-activated killer cells and cytotoxic T cells

1988 • 155 citations

Antitumor efficacy of lymphokine-activated killer cells and recombinant interleukin 2 in vivo: successful immunotherapy of established pulmonary metastases from weakly immunogenic and nonimmunogenic murine tumors of three district histological types.

1986 • 149 citations

Regulation of cytolytic cell populations from human peripheral blood by B cell stimulatory factor 1 (interleukin 4).

1987 • 137 citations

Interleukin 2 enhances natural killer cell activity through induction of gamma interferon

1983 • 134 citations

Natural killer-sensitive targets stimulate production of TNF-alpha but not TNF-beta (lymphotoxin) by highly purified human peripheral blood large granular lymphocytes.

1986 • 133 citations

Effects of transforming growth factor-beta on human lymphokine-activated killer cell precursors. Autocrine inhibition of cellular proliferation and differentiation to immune killer cells.

1988 • 117 citations

One-signal requirement for interferon-gamma production by human large granular lymphocytes.

1987 • 116 citations

IL-4 regulates IL-2 induction of lymphokine-activated killer activity from human lymphocytes.

1989 • 106 citations

Human T cells from autoimmune and normal individuals can produce tumor necrosis factor

1987 • 94 citations

Synergy of human recombinant interleukin 1 with interleukin 2 in the generation of lymphokine-activated killer cells.

1989 • 74 citations

Synergistic antitumor effects of tumor necrosis factor and gamma-interferon on human colon carcinoma cell lines.

1987 • 70 citations

Preparation and Characterization of Monoclonal Antibodies Directed Against Antigenic Determinants of Recombinant Human Tumour Necrosis Factor (rTNF)

1987 • 63 citations

Differential Effects of Recombinant Interferons , beta, and on Induction of Human Lymphokine (IL-2)-Activated Killer Activity

1988 • 62 citations

Tumour necrosis factor production by IL-2-activated macrophages in vitro and in vivo.

1989 • 58 citations

Regulation of human natural killer cell activity by interferon-gamma: lack of a role in interleukin 2-mediated augmentation.

1986 • 57 citations

Evidence for IL-2 independent proliferation in human T cells.

1988 • 51 citations

Interleukin-6 enhances the induction of human lymphokine-activated killer cells

1990 • 49 citations

TGF beta down-regulates TLiSA1 expression and inhibits the differentiation of precursor lymphocytes into CTL and LAK cells.

1989 • 46 citations

Cytokine gene expression during the generation of human lymphokine-activated killer cells: early induction of interleukin 1 beta by interleukin 2.

1989 • 45 citations

Functional interactions of IL2 and TNF in the differentiation of LGL into lak effectors

1989 • 33 citations

Release of cytokines during generation of lymphokine-activated killer (LAK) cells by IL-2.

1989 • 30 citations

IL-2- and IFNγ-enhanced natural cytotoxic activity: Analysis of the role of different lymphoid subsets and implications for activation routes

1986 • 29 citations

Functional differentiation of human lymphokine-activated killing (LAK) is distinct from expansion and involves dissimilar interleukin 2 receptors

1988 • 27 citations

Human recombinant IL-4 suppresses the induction of human IL-2 induced lymphokine activated killer (LAK) activity.

1988 • 26 citations

Interleukin-3 and interleukin-4 each strongly inhibit the induction and function of human LAK cells.

1988 • 25 citations

Transforming growth factor beta 1 (TGF‐β1) receptor expression on resting and mitogen‐activated T cells

1989 • 23 citations

Production of interferon and tumour necrosis factor by cloned human natural cytotoxic lymphocytes and T cells.

1987 • 22 citations

Interleukin 4 inhibits the interleukin 2-induced production of its functional antagonist, interferon gamma

1989 • 19 citations

Interferon-γ (IFN-γ) and interleukin-2 in the generation of lymphokine-activated killer cell cytotoxicity — IFN-γ-induced suppressive activity

1989 • 18 citations

Generation of lymphokine-activated killer cells does not require DNA synthesis.

1987 • 14 citations

Interleukin‐2 activated human killer lymphocytes: Lack of involvement of interferon in the development of IL‐2‐activated killer lymphocytes

1987 • 13 citations

The influence of interferon alpha and gamma, singly or in combination on human natural cell mediated cytotoxicity

1989 • 9 citations