Signaling through Mitogen-Activated Protein Kinase and Rac/Rho Does Not Duplicate the Effects of Activated Ras on Skeletal Myogenesis

ras oncogenes in human cancer: a review.

1989 • 5,116 citations

PD 098059 Is a Specific Inhibitor of the Activation of Mitogen-activated Protein Kinase Kinase in Vitro and in Vivo

1995 • 3,456 citations

A synthetic inhibitor of the mitogen-activated protein kinase cascade.

1995 • 2,723 citations

Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells

1994 • 1,999 citations

Phosphatidylinositol-3-OH kinase direct target of Ras

1994 • 1,923 citations

The SRF accessory protein Elk-1 contains a growth factor-regulated transcriptional activation domain

1993 • 1,313 citations

The Rho family GTPases RhoA, Racl , and CDC42Hsregulate transcriptional activation by SRF

1995 • 1,280 citations

Complexes of Ras⋅GTP with Raf-1 and Mitogen-Activated Protein Kinase Kinase

1993 • 987 citations

Activation of Raf as a Result of Recruitment to the Plasma Membrane

1994 • 979 citations

Integration of MAP Kinase Signal Transduction Pathways at the Serum Response Element

1995 • 935 citations

Immunochemical analysis of myosin heavy chain during avian myogenesis in vivo and in vitro.

1982 • 932 citations

Inhibition of MAP Kinase Kinase Blocks the Differentiation of PC-12 Cells Induced by Nerve Growth Factor

1995 • 906 citations

An essential role for Rac in Ras transformation

1995 • 895 citations

Activation of Rac1, RhoA, and Mitogen-Activated Protein Kinases Is Required for Ras Transformation

1995 • 683 citations

Multiple ras functions can contribute to mammalian cell transformation

1995 • 658 citations

Signal-transducing protein phosphorylation cascades mediated by Ras/Rho proteins in the mammalian cell: the potential for multiplex signalling

1996 • 503 citations

The MyoD family of transcription factors and skeletal myogenesis

1995 • 441 citations

Stimulation of Membrane Ruffling and MAP Kinase Activation by Distinct Effectors of RAS

1996 • 377 citations

Oncogenic Ras Activation of Raf/Mitogen-Activated Protein Kinase-Independent Pathways Is Sufficient To Cause Tumorigenic Transformation

1996 • 350 citations

Regulatory mechanisms that coordinate skeletal muscle differentiation and cell cycle withdrawal

1994 • 348 citations

Ral-GTPases mediate a distinct downstream signaling pathway from Ras that facilitates cellular transformation.

1996 • 335 citations

FGF inactivates myogenic helix-loop-helix proteins through phosphorylation of a conserved protein kinase C site in their DNA-binding domains

1992 • 333 citations

Transformation by activated ras or fos prevents myogenesis by inhibiting expression of MyoD1

1989 • 286 citations

Transcription factor families: muscling in on the myogenic program.

1995 • 261 citations

Critical role of Rho in cell transformation by oncogenic Ras.

1995 • 256 citations

A Role for the Ral Guanine Nucleotide Dissociation Stimulator in Mediating Ras-induced Transformation

1996 • 245 citations

The Ras-JNK Pathway Is Involved in Shear-Induced Gene Expression

1996 • 234 citations

Interaction of Ras and Raf in intact mammalian cells upon extracellular stimulation.

1994 • 221 citations

The oncogenic forms of N-ras or H-ras prevent skeletal myoblast differentiation.

1987 • 221 citations

Fibroblast Growth Factor and Transforming Growth Factor β Repress Transcription of the Myogenic Regulatory Gene MyoD1

1989 • 212 citations

Serum and fibroblast growth factor inhibit myogenic differentiation through a mechanism dependent on protein synthesis and independent of cell proliferation.

1986 • 196 citations

Association of p21ras with phosphatidylinositol 3-kinase.

1991 • 174 citations

Transforming growth factor beta represses the actions of myogenin through a mechanism independent of DNA binding.

1991 • 167 citations

Wiring diagrams: regulatory circuits and the control of skeletal myogenesis

1994 • 154 citations

Mitogen-Activated Protein Kinase

1996 • 132 citations

Inhibition of myogenic differentiation by the H-ras oncogene is associated with the down regulation of the MyoD1 gene.

1989 • 110 citations

Repression of myogenin function by TGF-beta 1 is targeted at the basic helix-loop-helix motif and is independent of E2A products.

1992 • 88 citations

Casein Kinase II Increases the Transcriptional Activities of MRF4 and MyoD Independently of Their Direct Phosphorylation

1996 • 84 citations

Dexamethasone-dependent inhibition of differentiation of C2 myoblasts bearing steroid-inducible N-ras oncogenes.

1988 • 72 citations

Ras p21^Val Inhibits Myogenesis without Altering the DNA Binding or Transcriptional Activities of the Myogenic Basic Helix-Loop-Helix Factors

1995 • 69 citations

Fibroblast Growth Factor Inhibits MRF4 Activity Independently of the Phosphorylation Status of a Conserved Threonine Residue within the DNA-Binding Domain

1993 • 60 citations

KSR: A novel player in the RAS pathway

1995 • 51 citations

Ras Partners

1994 • 51 citations

Distinct signaling pathways regulate transformation and inhibition of skeletal muscle differentiation by oncogenic Ras

1997 • 49 citations

Inhibition of myogenesis by the H-ras oncogene: implication of a role for protein kinase C.

1991 • 48 citations

Oncogenes and muscle differentiation: multiple mechanisms of interference.

1994 • 43 citations

Oncogene-mediated multistep transformation of C3H10T1/2 cells.

1987 • 37 citations

Novel phenotype of C3H 10T1/2 fibroblasts cotransfected with the c‐Ha‐ras and adenovirus 5 E1A oncogenes

1990 • 8 citations