Increased expression of NAD(P)H oxidase subunits, NOX4 and p22phox, in the kidney of streptozotocin-induced diabetic rats and its reversibity by interventive insulin treatment

Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage

2000 • 4,169 citations

Role of Oxidative Stress in Development of Complications in Diabetes

1991 • 3,774 citations

NAD(P)H Oxidase

2000 • 2,902 citations

Angiotensin II stimulates NADH and NADPH oxidase activity in cultured vascular smooth muscle cells.

1994 • 2,753 citations

Advanced Glycosylation End Products in Tissue and the Biochemical Basis of Diabetic Complications

1988 • 2,527 citations

Angiotensin II-mediated hypertension in the rat increases vascular superoxide production via membrane NADH/NADPH oxidase activation. Contribution to alterations of vasomotor tone.

1996 • 2,456 citations

High glucose level and free fatty acid stimulate reactive oxygen species production through protein kinase C--dependent activation of NAD(P)H oxidase in cultured vascular cells.

2000 • 1,537 citations

Cell transformation by the superoxide-generating oxidase Mox1

1999 • 1,457 citations

Protein kinase C activation and the development of diabetic complications.

1998 • 1,328 citations

Mechanisms Underlying Endothelial Dysfunction in Diabetes Mellitus

2001 • 1,192 citations

Hyperglycemic Pseudohypoxia and Diabetic Complications

1993 • 1,025 citations

Mechanisms of Increased Vascular Superoxide Production in Human Diabetes Mellitus

2002 • 970 citations

Superoxide Production and Expression of Nox Family Proteins in Human Atherosclerosis

2002 • 838 citations

Identification of Renox, an NAD(P)H oxidase in kidney

2000 • 824 citations

p22 Is a Critical Component of the Superoxide-generating NADH/NADPH Oxidase System and Regulates Angiotensin IIinduced Hypertrophy in Vascular Smooth Muscle Cells

1996 • 768 citations

Preferential elevation of protein kinase C isoform beta II and diacylglycerol levels in the aorta and heart of diabetic rats: differential reversibility to glycemic control by islet cell transplantation.

1992 • 743 citations

Increased NADH-Oxidase–Mediated Superoxide Production in the Early Stages of Atherosclerosis

1999 • 689 citations

p22phox mRNA Expression and NADPH Oxidase Activity Are Increased in Aortas From Hypertensive Rats

1997 • 555 citations

NADH oxidoreductase is a major source of superoxide anion in bovine coronary artery endothelium

1994 • 546 citations

A Novel Superoxide-producing NAD(P)H Oxidase in Kidney

2001 • 508 citations

p47phox is required for atherosclerotic lesion progression in ApoE–/– mice

2001 • 478 citations

Purified cytochrome b from human granulocyte plasma membrane is comprised of two polypeptides with relative molecular weights of 91,000 and 22,000.

1987 • 459 citations

Correlation of diacylglycerol level and protein kinase C activity in rat retina to retinal circulation

1993 • 306 citations

Hyperglycemic pseudohypoxia and diabetic complications

1993 • 305 citations

Reactive oxygen species: production and role in the kidney

1986 • 267 citations

Expression of NADH/NADPH Oxidase p22 ^phox in Human Coronary Arteries

1999 • 259 citations

The structure of human mitochondrial DNA variation

1991 • 243 citations

Accumulation of 8-Hydroxy-2′-Deoxyguanosine and Mitochondrial DNA Deletion in Kidney of Diabetic Rats

2002 • 199 citations

Apoptotic mechanisms in acute renal failure

2000 • 191 citations

Phosphoinositide 3-Kinase-dependent and -independent Activation of the Small GTPase Rac2 in Human Neutrophils

1999 • 172 citations

Vascular NADH Oxidase Is Involved in Impaired Endothelium-Dependent Vasodilation in OLETF Rats, a Model of Type 2 Diabetes

2002 • 157 citations

Phosphorylation of the Respiratory Burst Oxidase Subunit p67 during Human Neutrophil Activation

1997 • 154 citations

Vascular targets of redox signalling in diabetes mellitus

2002 • 150 citations

DNA damage in the kidneys of diabetic rats exhibiting microalbuminuria

1994 • 120 citations

p47phox is required for atherosclerotic lesion progression in ApoE–/– mice

2001 • 119 citations

Analysis of Activation-induced Conformational Changes in p47 Using Tryptophan Fluorescence Spectroscopy

1997 • 100 citations

Aldose reductase and myo-inositol in endothelial cell dysfunction caused by elevated glucose.

1992 • 33 citations