Rejection of H-Y Disparate Skin Grafts by Monospecific CD4+ Th1 and Th2 Cells: No Requirement for CD8+ T Cells or B Cells

Design and analysis of randomized clinical trials requiring prolonged observation of each patient. II. Analysis and examples

1977 • 8,468 citations

Regulatory T Cell Clones Induced by Oral Tolerance: Suppression of Autoimmune Encephalomyelitis

1994 • 1,995 citations

Differential production of interferon-γ and interleukin-4 in response to Th1- and Th2-stimulating pathogens by γδ T cells in vivo

1995 • 672 citations

Myelin Basic Protein–specific T Helper 2 (Th2) Cells Cause Experimental Autoimmune Encephalomyelitis in Immunodeficient Hosts Rather than Protect Them from the Disease

1997 • 433 citations

Monoclonal antibodies to promote marrow engraftment and tissue graft tolerance

1986 • 344 citations

T cell receptor genes in a series of class I major histocompatibility complex-restricted cytotoxic T lymphocyte clones specific for a Plasmodium berghei nonapeptide: implications for T cell allelic exclusion and antigen-specific repertoire.

1991 • 323 citations

CD4+ but not CD8+ cells are essential for allorejection.

1996 • 303 citations

Induction of tolerance in peripheral T cells with monoclonal antibodies

1990 • 285 citations

T Helper 2 (Th2) T Cells Induce Acute Pancreatitis and Diabetes in Immune-compromised Nonobese Diabetic (NOD) Mice

1997 • 223 citations

Rejection of skin allografts by indirect allorecognition of donor class I major histocompatibility complex peptides.

1992 • 218 citations

A fail-safe mechanism for maintaining self-tolerance.

1992 • 213 citations

IN VIVO DEPLETION OF CD8+ T CELLS RESULTS IN Th2 CYTOKINE PRODUCTION AND ALTERNATE MECHANISMS OF ALLOGRAFT REJECTION

1995 • 190 citations

THE MALE-SPECIFIC HISTOCOMPATIBILITY ANTIGEN, H-Y:A History of Transplantation, Immune Response Genes, Sex Determination and Expression Cloning

1997 • 155 citations

T cell regulation in adult transplantation tolerance.

1996 • 144 citations

Skin graft rejection by beta 2-microglobulin-deficient mice.

1992 • 142 citations

IL-12 antagonism induces T helper 2 responses, yet exacerbates cardiac allograft rejection. Evidence against a dominant protective role for T helper 2 cytokines in alloimmunity.

1996 • 135 citations

Tolerance in the mouse to major histocompatibility complex‐mismatched heart allografts, and to rat heart xenografts, using monoclonal antibodies to CD4 and CD8

1992 • 128 citations

SKIN ALLOGRAFT REJECTION BY L3/t4+ AND LYT-2+ T CELL SUBESTS

1986 • 119 citations

INDUCTION OF DONOR-SPECIFIC UNRESPONSIVENESS TO CARDIAC ALLOGRAFTS IN RATS BY PRETRANSPLANT ANTI-CD4 MONOCLONAL ANTIBODY THERAPY

1990 • 118 citations

TRANSFUSION OF POLARIZED TH2-LIKE CELL POPULATIONS INTO SCID MOUSE CARDIAC ALLOGRAFT RECIPIENTS RESULTS IN ACUTE ALLOGRAFT REJECTION1,2

1996 • 107 citations

Alloreactive cytotoxic T cells can develop and function in mice lacking both CD4 and CD8

1993 • 101 citations

THE ASSESSMENT OF TRANSPLANTATION TOLERANCE INDUCED BY ANTI-CD4 MONOCLONAL ANTIBODY IN THE MURINE MODEL1

1993 • 79 citations

Cellular basis of skin allograft rejection across a class I major histocompatibility barrier in mice depleted of CD8+ T cells in vivo.

1991 • 76 citations

Adoptively transferred CD4+ lymphocytes from CD8 -/- mice are sufficient to mediate the rejection of MHC class II or class I disparate skin grafts.

1996 • 72 citations

What are minor histocompatibility loci? A new look at an old question

1992 • 69 citations

Role of lymphokine-secreting CD8+ T cells in cytotoxic T lymphocyte responses against vaccinia virus.

1989 • 63 citations

CD4⁺ T cell‐mediated rejection of major histocompatibility complex class I‐disparate grafts: A role for alloantibody

1993 • 61 citations

CD4 and CD8 expression by human and mouse thymic dendritic cells

1994 • 59 citations

In Vivo use of monoclonal antibodies against murine T cell antigens

1989 • 56 citations

Beta 2M-/- knockout mice contain low levels of CD8+ cytotoxic T lymphocyte that mediate specific tumor rejection.

1993 • 56 citations

THE ROLE OF THE PERFORIN AND Fas PATHWAYS OF CYTOTOXICITY IN SKIN GRAFT REJECTION1,2

1996 • 41 citations

T cell tolerance and activation to a transgene‐encoded tumor antigen

1996 • 39 citations

A tumor-specific Th2 clone initiating tumor rejection via primed CD8+ cytotoxic T-lymphocyte activation in mice.

1996 • 38 citations

T-cell receptor expressed on an autoreactive T-cell clone, clone 4

1985 • 28 citations

CD4+ T CELLS ARE ABLE TO REJECT CLASS I DISPARATE ALLOGRAFTS1

1997 • 27 citations

T CELL SUBSETS REQUIRED FOR IN VIVO AND IN VITRO RESPONSES TO SINGLE AND MULTIPLE MINOR HISTOCOMPATIBILITY ANTIGENS

1992 • 25 citations

Rejection of skin allografts by CD4+ T cells is antigen-specific and requires expression of target alloantigen on Ia- epidermal cells.

1989 • 22 citations

Some cloned murine CD4+ T cells recognize H-2Ld class I MHC determinants directly. Other cloned CD4+ T cells recognize H-2Ld class I MHC determinants in the context of class II MHC molecules.

1991 • 21 citations

Differential involvement of CD4+ cells in mediating skin graft rejection against different amounts of transgenic H-2K(b) antigen.

1991 • 20 citations

ADOPTIVE IMMUNITY IN IMMUNE-DEFICIENT scid/scid MICE

1988 • 14 citations

Alloantigenic sites on class I major histocompatibility complex antigens: 61-69 region in the first domain of the H-2Kb molecule induces specific antibody and T cell responses.

1986 • 10 citations

PEPTIDE SPECIFICITY OF ALLOREACTIVE CD4 POSITIVE T LYMPHOCYTES DIRECTED AGAINST A MAJOR HISTOCOMPATIBILITY COMPLEX CLASS I DISPARITY1

1996 • 10 citations

GENETIC CONTROL AND EFFECTOR CELLS IN HOST-VERSUS-GRAFT RESPONSES TO H-Y ANTIGEN IN MICE

1983 • 8 citations

Deleted Work

1955 • 0 citations