Antiparasitic and antiproliferative effects of indoleamine 2,3-dioxygenase enzyme expression in human fibroblasts

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Role of nitric oxide synthesis in macrophage antimicrobial activity

1991 • 1,547 citations

The Molecular Cell Biology of Interferon-gamma and its Receptor

1993 • 1,323 citations

Interferon-γ: the Major Mediator of Resistance Against Toxoplasma gondii

1988 • 1,150 citations

Interferon gamma blocks the growth of Toxoplasma gondii in human fibroblasts by inducing the host cells to degrade tryptophan.

1984 • 847 citations

Microbiostatic effect of murine-activated macrophages for Toxoplasma gondii. Role for synthesis of inorganic nitrogen oxides from L-arginine.

1990 • 573 citations

Quinolinic acid in cerebrospinal fluid and serum in HIV‐1 Infection: Relationship to clinical and neurological status

1991 • 563 citations

Requirement of endogenous interferon-gamma production for resolution of Listeria monocytogenes infection.

1985 • 555 citations

Mechanism of interferon-gamma action. Characterization of indoleamine 2,3-dioxygenase in cultured human cells induced by interferon-gamma and evaluation of the enzyme-mediated tryptophan degradation in its anticellular activity.

1988 • 459 citations

Leishmania major amastigotes initiate the L-arginine-dependent killing mechanism in IFN-gamma-stimulated macrophages by induction of tumor necrosis factor-alpha.

1990 • 453 citations

Interferon-Gamma, the Activated Macrophage, and Host Defense Against Microbial Challenge

1988 • 428 citations

Induction of tryptophan catabolism is the mechanism for gamma-interferon-mediated inhibition of intracellular Chlamydia psittaci replication in T24 cells

1986 • 389 citations

Administration of monoclonal anti-IFN-gamma antibodies in vivo abrogates natural resistance of C3H/HeN mice to infection with Leishmania major.

1989 • 374 citations

Differential efficacies of human type I and type II interferons as antiviral and antiproliferative agents.

1980 • 286 citations

Induction of indoleamine 2,3-dioxygenase: a mechanism of the antitumor activity of interferon gamma.

1988 • 241 citations

A unique set of polypeptides is induced by γ interferon in addition to those induced in common with α and β interferons

1983 • 234 citations

Toxoplasma gondii: Isolation and preliminary characterization of temperature-sensitive mutants

1976 • 210 citations

Cerebrospinal fluid quinolinic acid concentrations are increased in acquired immune deficiency syndrome

1989 • 190 citations

Interferon-γ suppresses the growth of Toxoplasma gondii in human fibroblasts through starvation for tryptophan

1986 • 161 citations

IFN-gamma-mediated antimicrobial response. Indoleamine 2,3-dioxygenase-deficient mutant host cells no longer inhibit intracellular Chlamydia spp. or Toxoplasma growth.

1993 • 146 citations

Competition between Chlamydia psittaci and L cells for host isoleucine pools: a limiting factor in chlamydial multiplication

1975 • 139 citations

Inhibition of growth of Toxoplasma gondii in cultured fibroblasts by human recombinant gamma interferon

1984 • 139 citations

Interferon-Induced Indoleamine 2,3-Dioxygenase Activity InhibitsChlamydia psittaciReplication in Human Macrophages

1989 • 136 citations

Immune Activation and Decreased Tryptophan in Patients with HIV-1 Infection

1990 • 105 citations

Gamma interferon-induced nitric oxide production reduces Chlamydia trachomatis infectivity in McCoy cells

1993 • 103 citations

Poliovirus induces indoleamine‐2,3‐dioxygenase and quinolinic acid synthesis in macaque brain

1992 • 98 citations

Molecular cloning, sequencing and expression of human interferon-γ-inducible indoleamine 2,3-dioxygenase cDNA

1990 • 92 citations

Direct cytolysis by partially‐purified preparations of immune interferon

1982 • 74 citations

Dependence of the in vitro antiproliferative activity of recombinant human gamma-interferon on the concentration of tryptophan in culture media.

1988 • 71 citations

Rapid separation of tryptophan, kynurenines, and indoles using reversed-phase high-performance liquid chromatography

1979 • 63 citations

Lymphokine-mediated microbistatic mechanisms restrict Chlamydia psittaci growth in macrophages.

1982 • 62 citations

Interferon gamma-resistant mutants are defective in the induction of indoleamine 2,3-dioxygenase.

1989 • 61 citations

Role of endogenous gamma interferon in host defense against Chlamydia trachomatis infections

1989 • 58 citations

Differential regulation of a cellular gene by human interferon-gamma and interferon-alpha.

1988 • 56 citations

Establishment of an antitoxoplasma state by stable expression of mouse indoleamine 2,3-dioxygenase

1993 • 40 citations

Tryptophan reversal of recombinant human gamma-interferon inhibition ofChlamydia trachomatis growth

1987 • 34 citations

Murine gamma interferon fails to inhibit Toxoplasma gondii growth in murine fibroblasts

1990 • 31 citations

The Interferons, Macrophage Activation, and Host Defense Against Nonviral Pathogens

1992 • 30 citations

Decreased whole blood 5-hydroxytryptamine (serotonin) in AIDS patients.

1988 • 18 citations