A dual role for mitochondrial heat shock protein 70 in membrane translocation of preproteins.

Molecular Cloning: A Laboratory Manual

2001 • 133,517 citations

THE HEAT-SHOCK PROTEINS

1988 • 5,214 citations

Protein folding in the cell

1992 • 4,138 citations

Methods in Yeast Genetics: A Laboratory Course Manual

1990 • 1,922 citations

A subfamily of stress proteins facilitates translocation of secretory and mitochondrial precursor polypeptides

1988 • 1,504 citations

An hsp70-like protein in the ER: Identity with the 78 kd glucose-regulated protein and immunoglobulin heavy chain binding protein

1986 • 1,457 citations

Interaction of Hsp 70 with Newly Synthesized Proteins: Implications for Protein Folding and Assembly

1990 • 1,293 citations

The presence of malfolded proteins in the endoplasmic reticulum signals the induction of glucose-regulated proteins

1988 • 1,292 citations

Three-dimensional structure of the ATPase fragment of a 70K heat-shock cognate protein

1990 • 1,035 citations

Polypeptide chain binding proteins: Catalysts of protein folding and related processes in cells

1989 • 884 citations

Requirement for hsp70 in the mitochondrial matrix for translocation and folding of precursor proteins

1990 • 756 citations

KAR2, a karyogamy gene, is the yeast homolog of the mammalian BiP/GRP78 gene

1989 • 684 citations

Protein folding in mitochondria requires complex formation with hsp60 and ATP hydrolysis

1989 • 676 citations

Peptide sequences that target cytosolic proteins for lysosomal proteolysis

1990 • 674 citations

The translation machinery and 70 kd heat shock protein cooperate in protein synthesis

1992 • 512 citations

Molecular chaperones: proteins essential for the biogenesis of some macromolecular structures

1989 • 491 citations

Transport of proteins into mitochondria: Translocational intermediates spanning contact sites between outer and inner membranes

1985 • 470 citations

Loss of BiP/GRP78 function blocks translocation of secretory proteins in yeast.

1990 • 435 citations

Cytochromes c1 and b2 are sorted to the intermembrane space of yeast mitochondria by a stop-transfer mechanism

1992 • 422 citations

What drives the translocation of proteins?

1992 • 415 citations

Mitochondrial protein import: Identification of processing peptidase and of PEP, a processing enhancing protein

1988 • 388 citations

70-kD heat shock-related protein is one of at least two distinct cytosolic factors stimulating protein import into mitochondria.

1988 • 380 citations

Role of an energized inner membrane in mitochondrial protein import. Delta psi drives the movement of presequences.

1991 • 372 citations

Sec61p and BiP directly facilitate polypeptide translocation into the ER

1992 • 370 citations

Complex Interactions Among Members of an Essential Subfamily of hsp70 Genes in Saccharomyces Cerevisiae

1987 • 358 citations

Similarity of the three-dimensional structures of actin and the ATPase fragment of a 70-kDa heat shock cognate protein.

1991 • 352 citations

Assembly and secretion of heavy chains that do not associate posttranslationally with immunoglobulin heavy chain-binding protein.

1987 • 343 citations

The transport of proteins into the nucleus requires the 70-kilodalton heat shock protein or its cytosolic cognate.

1992 • 335 citations

Mitochondrial protein import: Nucleoside triphosphates are involved in conferring import-competence to precursors

1987 • 322 citations

A mitochondrial import receptor for the ADP/ATP carrier

1990 • 296 citations

Successive translocation into and out of the mitochondrial matrix: Targeting of proteins to the intermembrane space by a bipartite signal peptide

1987 • 275 citations

The ATPase core of a clathrin uncoating protein.

1987 • 259 citations

Distinct steps in the import of ADP/ATP carrier into mitochondria.

1987 • 248 citations

How do polypeptides cross the mitochondrial membranes?

1990 • 246 citations

A precursor protein partly translocated into yeast mitochondria is bound to a 70 kd mitochondrial stress protein.

1990 • 242 citations

Sequential action of mitochondrial chaperones in protein import into the matrix.

1991 • 221 citations

Heavy-chain binding protein recognizes aberrant polypeptides translocated in vitro

1988 • 219 citations

The Nuclear Membrane

1992 • 206 citations

SSC1, a member of the 70-kDa heat shock protein multigene family of Saccharomyces cerevisiae, is essential for growth.

1987 • 205 citations

A hypothetical model for the peptide binding domain of hsp70 based on the peptide binding domain of HLA.

1991 • 191 citations

Seventy-kilodalton heat shock proteins and an additional component from reticulocyte lysate stimulate import of M13 procoat protein into microsomes.

1988 • 187 citations

Transport of F₁‐ATPase subunit β into mitochondria depends on both a membrane potential and nucleoside triphosphates

1986 • 182 citations

Antibodies against 70-kD heat shock cognate protein inhibit mediated nuclear import of karyophilic proteins.

1992 • 176 citations

Reconstitution of protein translocation from solubilized yeast membranes reveals topologically distinct roles for BiP and cytosolic Hsc70.

1993 • 171 citations

A dynamic model of the mitochondrial protein import machinery

1992 • 160 citations

Import pathways of precursor proteins into mitochondria: multiple receptor sites are followed by a common membrane insertion site.

1988 • 159 citations

Presequence and mature part of preproteins strongly influence the dependence of mitochondrial protein import on heat shock protein 70 in the matrix.

1993 • 158 citations

Processing peptidase of Neurospora mitochondria. Two-step cleavage of imported ATPase subunit 9

1984 • 157 citations

Translocation of proteins into isolated chloroplasts requires cytosolic factors to obtain import competence

1990 • 142 citations

Which came first, MHC class I or class II?

1991 • 132 citations

Mitochondrial protein import

1989 • 131 citations

Chapter 16 Analysis of Mitochondrial Protein Import Using Translocation Intermediates and Specific Antibodies

1991 • 115 citations

Posttranslational folding of vesicular stomatitis virus G protein in the ER: involvement of noncovalent and covalent complexes.

1993 • 113 citations

Purified presequence binding factor (PBF) forms an import-competent complex with a purified mitochondrial precursor protein.

1990 • 113 citations

Disrupted yeast mitochondria can import precursor proteins directly through their inner membrane.

1989 • 108 citations

Protein import into the yeast mitochondrial matrix. A new translocation intermediate between the two mitochondrial membranes.

1991 • 107 citations

Precursor proteins in transit through mitochondrial contact sites interact with hsp70 in the matrix

1990 • 98 citations

Disruption of the outer membrane restores protein import to trypsin-treated yeast mitochondria.

1987 • 96 citations

Bidirectional movement of a nascent polypeptide across microsomal membranes reveals requirements for vectorial translocation of proteins

1992 • 93 citations

The Transport of Proteins into the Nucleus Requires the 70-Kilodalton Heat Shock Protein or Its Cytosolic Cognate

1992 • 92 citations

Mitochondrial preproteins en route from the outer membrane to the inner membrane are exposed to the intermembrane space

1991 • 90 citations

Role of ATP in the intramitochondrial sorting of cytochrome c1 and the adenine nucleotide translocator.

1992 • 83 citations

Sequential translocation of an artificial precursor protein across the two mitochondrial membranes.

1992 • 48 citations

Precursor of mitochondrial aspartate aminotransferase synthesized in Escherichia coli is complexed with heat‐shock protein DnaK

1992 • 33 citations

Transport of Proteins into the Nucleus

1988 • 26 citations