The Transport of Proteins into the Nucleus Requires the 70-Kilodalton Heat Shock Protein or Its Cytosolic Cognate

THE HEAT-SHOCK PROTEINS

1988 • 5,214 citations

A subfamily of stress proteins facilitates translocation of secretory and mitochondrial precursor polypeptides

1988 • 1,504 citations

Heat shock proteins.

1990 • 1,365 citations

Interaction of Hsp 70 with Newly Synthesized Proteins: Implications for Protein Folding and Assembly

1990 • 1,293 citations

70K heat shock related proteins stimulate protein translocation into microsomes

1988 • 1,276 citations

A Role for a 70-Kilodalton Heat Shock Protein in Lysosomal Degradation of Intracellular Proteins

1989 • 932 citations

Nuclear protein import in permeabilized mammalian cells requires soluble cytoplasmic factors.

1990 • 909 citations

Polypeptide chain binding proteins: Catalysts of protein folding and related processes in cells

1989 • 884 citations

Chaperonin-mediated protein folding at the surface of groEL through a 'molten globule'-like intermediate

1991 • 853 citations

Peptide Binding and Release by Proteins Implicated as Catalysts of Protein Assembly

1989 • 763 citations

Requirement for hsp70 in the mitochondrial matrix for translocation and folding of precursor proteins

1990 • 756 citations

Uncoating ATPase is a member of the 70 kilodalton family of stress proteins

1986 • 607 citations

Nuclear protein localization

1991 • 570 citations

A polypeptide domain that specifies migration of nucleoplasmin into the nucleus

1982 • 556 citations

How proteins enter the nucleus

1991 • 555 citations

Nuclear protein migration involves two steps: Rapid binding at the nuclear envelope followed by slower translocation through nuclear pores

1988 • 551 citations

Nuclear import can be separated into distinct steps in vitro: Nuclear pore binding and translocation

1988 • 535 citations

Correlation between structure and mass distribution of the nuclear pore complex and of distinct pore complex components.

1990 • 510 citations

Cytosolic proteins that specifically bind nuclear location signals are receptors for nuclear import

1991 • 391 citations

Involvement of ATP in the nuclear and nucleolar functions of the 70 kd heat shock protein.

1985 • 327 citations

Expression of human HSP70 during the synthetic phase of the cell cycle.

1986 • 316 citations

A yeast gene important for protein assembly into the endoplasmic reticulum and the nucleus has homology to DnaJ, an Escherichia coli heat shock protein.

1989 • 296 citations

Facilitated nuclear transport of histone H1 and other small nucleophilic proteins

1990 • 278 citations

A precursor protein partly translocated into yeast mitochondria is bound to a 70 kd mitochondrial stress protein.

1990 • 242 citations

A complex of nuclear pore proteins required for pore function.

1991 • 231 citations

Mammalian mitochondrial chaperonin 60 functions as a single toroidal ring.

1992 • 217 citations

In vitro transport of a fluorescent nuclear protein and exclusion of non-nuclear proteins.

1986 • 211 citations

Protein import through the nuclear pore complex is a multistep process.

1989 • 208 citations

Heat shock and the sorting of luminal ER proteins.

1989 • 178 citations

Mitochondrial precursor protein. Effects of 70-kilodalton heat shock protein on polypeptide folding, aggregation, and import competence.

1990 • 170 citations

Cell cycle-dependent association of HSP70 with specific cellular proteins.

1989 • 145 citations

Heat shock proteins and cell proliferation

1991 • 137 citations

An N-ethylmaleimide-sensitive cytosolic factor necessary for nuclear protein import: requirement in signal-mediated binding to the nuclear pore.

1990 • 128 citations

Identification of two HSP70-related Xenopus oocyte proteins that are capable of recycling across the nuclear envelope.

1990 • 108 citations

Multiple pathways in nuclear transport: the import of U2 snRNP occurs by a novel kinetic pathway.

1991 • 105 citations

Rapid Purification of Mammalian 70,000-Dalton Stress Proteins: Affinity of the Proteins for Nucleotides

1985 • 104 citations

Association of a cellular heat shock protein with simian virus 40 large T antigen in transformed cells

1989 • 99 citations

A heat shock‐like protein from the human malaria parasite plasmodium falciparum induces autoantibodies

1989 • 80 citations

β-internexin is a microtubule-associated protein identical to the 70-kDa heat-shock cognate protein and the clathrin uncoating ATPase

1989 • 73 citations

Identification of a human protein that interacts with nuclear localization signals.

1989 • 62 citations

Immunological Evidence for the Association of P53 with a Heat Shock Protein, hsc70, in p53-plus-ras-Transformed Cell Lines

1987 • 56 citations

The v-rel oncogene product is complexed with cellular proteins including its proto-oncogene product and heat shock protein 70

1990 • 44 citations

E1a Transactivation of the Human HSP70 Promoter Is Mediated through the Basal Transcriptional Complex

1989 • 38 citations

The cellular proteins which can associate specifically with polyomavirus middle T antigen in human 293 cells include the major human 70-kilodalton heat shock proteins

1989 • 27 citations

Peptide mapping of conformational epitopes in a human malarial parasite heat shock protein.

1989 • 16 citations