The Mutagenicity of Chemical Carcinogens: Correlations, Problems, and Interpretations

Chemical Mutagens. Principles and Methods for Their Detection.

1974 • 1,473 citations

Carcinogenesis by chemicals: an overview--G. H. A. Clowes memorial lecture.

1970 • 1,464 citations

[Organotropic carcinogenic effects of 65 various N-nitroso- compounds on BD rats].

1967 • 1,408 citations

Organotrope carcinogene Wirkungen bei 65 verschiedenen N-Nitroso-Verbindungen an BD-Ratten

1967 • 1,336 citations

Carcinogenic Nitroso Compounds

1967 • 1,109 citations

Possible Relevance of O–6 Alkylation of Deoxyguanosine to the Mutagenicity and Carcinogenicity of Nitrosamines and Nitrosamides

1969 • 949 citations

FURTHER STUDIES ON THE ALKYLATION OF NUCLEIC ACIDS AND THEIR CONSTITUENT NUCLEOTIDES

1963 • 801 citations

ASCORBIC ACID IN AROMATIC HYDROXYLATION

1954 • 679 citations

Bioassay of Pesticides and Industrial Chemicals for Tumorigenicity in Mice: A Preliminary Note<xref ref-type="fn" rid="FN2">2</xref><xref ref-type="fn" rid="FN3">3</xref>

1969 • 523 citations

Methylation of deoxyribonucleic acid in cultured mammalian cells by N-methyl-N′-nitro-N-nitrosoguanidine. The influence of cellular thiol concentrations on the extent of methylation and the 6-oxygen atom of guanine as a site of methylation

1970 • 500 citations

Mechanisms of chemical carcinogenesis: nature of proximate carcinogens and interactions with macromolecules.

1966 • 489 citations

Toxicity of Pyrrolizidine Alkaloids

1968 • 474 citations

The Chemical Production of Mutations

1947 • 437 citations

Nitrosamine-induced carcinogenesis. The alkylation of nucleic acids of the rat by N-methyl-N-nitrosourea, dimethylnitrosamine, dimethyl sulphate and methyl methanesulphonate

1968 • 378 citations

Effects of Some Chemical Mutagens and Carcinogens on Nucleic Acids

1966 • 370 citations

Acridine mutagens and DNA structure

1964 • 358 citations

Repair Replication of Mammalian Cell DNA: Effects of Compounds That Inhibit DNA Synthesis or Dark Repair

1969 • 355 citations

Biological Alkylating Agents

1962 • 355 citations

N-hydroxy-2-acetylaminofluorene sulfotransferase: its probable role in carcinogenesis and in protein-(methion-S-yl) binding in rat liver.

1970 • 354 citations

Survey of Compounds Which Have Been Tested for Carcinogenic Activity

1942 • 354 citations

The Metabolic Activation of Carcinogenic Aromatic Amines and Amides1

2015 • 349 citations

N-Hydroxy-2-acetylaminofluorene: a metabolite of 2-acetylaminofluorene with increased carcinogenic activity in the rat.

1961 • 336 citations

8-(N-2-Fluorenylacetamido) guanosine, an Arylamidation Reaction Product of Guanosine and the Carcinogen N-Acetoxy-N-2-fluorenylacetamide in Neutral Solution^*

1967 • 335 citations

A microsome-dependent binding of benzo[a]pyrene to DNA.

1969 • 332 citations

The Carcinogenic Aminoazo Dyes

1953 • 325 citations

Origin of Malignant Tumors.

1929 • 325 citations

Ethionine Carcinogenesis

1963 • 296 citations

Transmethylation and methionine biosynthesis

1965 • 276 citations

Das Krebsproblem

1963 • 266 citations

Enzyme-catalysed reactions of polycyclic hydrocarbons with deoxyribonucleic acid and protein in vitro

1968 • 261 citations

Reduction of carbon tetrachloride in vivo and reduction of carbon tetrachloride and chloroform in vitro by tissues and tissue constituents.

1961 • 249 citations

The Carcinogenic Action and Metabolism of Urethan and N-Hydroxyurethan

1969 • 242 citations

The reaction of mustard gas with nucleic acids in vitro and in vivo

1960 • 227 citations

Chemical Mutagens in the Human Environment

1968 • 224 citations

A Host-Mediated Microbial Assay for the Detection of Mutagenic Compounds

1969 • 209 citations

Biological Alkylating Agents

1962 • 209 citations

THE COMPARATIVE CARCINOGENICITIES OF 2-ACETYLAMINOFLUORENE AND ITS N-HYDROXY METABOLITE IN MICE, HAMSTERS, AND GUINEA PIGS.

1964 • 202 citations

A Survey of Chemicals for Mutagenic Action on E. coli

1951 • 191 citations

Chemistry, Carcinogenicity, and Metabolism of 2-Fluorenamine and Related Compounds

1958 • 189 citations

CHEMICAL MUTAGENS: PRINCIPLES AND METHODS FOR THEIR DETECTION

1972 • 186 citations

Chemical Carcinogenesis.

1963 • 180 citations

Carcinogenic action of 4-nitroquinoline-N-oxide.

1957 • 175 citations

THE CHEMICAL AND MUTAGENIC SPECIFICITY OF HYDROXYLAMINE

1961 • 174 citations

METABOLIC REGULATORY CIRCUITS AND CARCINOGENESIS.

1963 • 172 citations

Carcinogens, Enzyme Induction, and Gene Action

1967 • 172 citations

Toxicology and carcinogenic action of pyrrolizidine alkaloids.

1968 • 154 citations

Nucleic Acid Guanine: Reaction with the Carcinogen N -Acetoxy-2-Acetylaminofluorene

1966 • 151 citations

Studies on Methylazoxymethanol, the Aglycone of Cycasin: Methylation of Nucleic Acids in vitro

1966 • 148 citations

Chemical nature and biological effects of the aflatoxins.

1966 • 147 citations

METABOLISM OF POLYCYCLIC COMPOUNDS. THE METABOLISM OF 7,12-DIMETHYLBENZ[α]ANTHRACENE BY RAT-LIVER HOMOGENATES

1965 • 142 citations

Reactivity in vivo of the Carcinogen N -Hydroxy-2-acetylaminofluorene: Increase by Sulfate Ion

1970 • 141 citations

Chemical Carcinogenesis and Cancers

1965 • 141 citations

CARCINOGENIC EPOXIDES, LACTONES, AND HALO‐ETHERS AND THEIR MODE OF ACTION*

1969 • 139 citations

On the mechanism of action of carcinogenic aromatic amines

1969 • 138 citations

CHEMICAL STRUCTURE AND CARCINOGENICITY OF ALIPHATIC HYDRAZO, AZO, AND AZOXY COMPOUNDS AND OF TRIAZENES, POTENTIAL IN VIVO ALKYLATING AGENTS*

1969 • 137 citations

N‐NITROSO COMPOUNDS IN ORGANOTROPIC AND TRANSPLACENTAL CARCINOGENESIS*

1969 • 136 citations

On the Carcinogenicity of an Iron-Dextran Complex<xref ref-type="fn" rid="FN1">2</xref>

1960 • 136 citations

The carcinogenicity of compounds related to 2-acetylaminofluorene. II. Variations in the bridges and the 2-substituent.

1955 • 135 citations

Toxicology of cycasin.

1968 • 132 citations

The significance of mutation in relation to the origin of tumors: a review.

1955 • 129 citations

The metabolism of benz[a]anthracene and dibenz[a,h]anthracene and their 5,6-epoxy-5,6-dihydro derivatives by rat-liver homogenates

1965 • 129 citations

Production of Mutations by Allyl Isothiocyanate

1944 • 127 citations

MOUSE BLADDER CARCINOGENICITY OF CERTAIN TRYPTOPHAN METABOLITES AND OTHER AROMATIC NITROGEN COMPOUNDS SUSPENDED IN CHOLESTEROL.

1964 • 125 citations

Reaction of esters of aromatic -hydroxy amines and amides with methionine : A model for binding of amine carcinogens to protein

1966 • 125 citations

Mutagenic and Inactivating DNA Alterations

1966 • 122 citations

Early incorporation of carbon-labeled carbon tetrachloride into rat liver particulate lipids and proteins

1969 • 122 citations

Survey of Compounds Which Have Been Tested for Carcinogenic Activity

1953 • 120 citations

Mutations and decreases in density of transforming DNA produced by derivatives of the carcinogens 2-acetyl-aminofluorene and N-methyl-4-aminoazobenzene.

1968 • 118 citations

CHEMICALLY INDUCED MUTATIONS IN NEUROSPORA

1951 • 115 citations

Interactions of the k-region epoxides of phenanthrene and dibenz[a,h]anthracene with nucleic acids and histone

1970 • 115 citations

Liver parenchymal cell injury. IV. Pattern of incorporation of carbon and chlorine from carbon tetrachloride into chemical constituents of liver in vivo.

1967 • 115 citations

THE METABOLISM OF URETHANE AND RELATED COMPOUNDS

1965 • 114 citations

Reaction of some mutagenic and carcinogenic compounds with nucleic acids

1964 • 113 citations

Chemistry of Guanine and Its Biologically Significant Derivatives

1968 • 112 citations

The Chemical Production of Mutations

1967 • 111 citations

Mechanism of carcinogenesis with 1-Aryl-3,3-dialkyltriazenes. Enzymatic dealkylation by rat liver microsomal fraction in vitro

1969 • 110 citations

Induction of Adrenal Damage and Cancer with Metabolites of 7,12-Dimethylbenz(a)Anthracene

1965 • 110 citations

The N-Hydroxylation of 4-Acetylaminobiphenyl by the Rat and Dog and the Strong Carcinogenicity of N-Hydroxy-4-acetylaminobiphenyl in the Rat

1961 • 110 citations

Carcnogenicity of epoxides, lactones, and peroxy compounds. VI. Structure and carcinogenic activity.

1967 • 106 citations

PYRROLIZIDINE ALKALOIDS AS ALKYLATING AND ANTIMITOTIC AGENTS*

1969 • 106 citations

Studies on Methylazoxymethanol: Methylation of Nucleic Acids in the Fetal Rat Brain

1969 • 106 citations

CARCINOGENESIS BY NITROSO COMPOUNDS

1964 • 105 citations

POLYCYCLIC HYDROCARBONS

1964 • 104 citations

Tumor Induction in Germfree Rats With Methylazoxymethanol (MAM) and Synthetic MAM Acetate<xref ref-type="fn" rid="FN1">2</xref>

1967 • 103 citations

MUTAGENIC ACTION OF MANGANOUS CHLORIDE

1951 • 103 citations

Mutationstheorie der Geschwulst-Entstehung

1928 • 102 citations

Persistent binding of 2-acetylaminofluorene to rat liver DNA in vivo and consideration of the mechanism of binding of N-hydroxy-2-acetylaminofluorene to rat liver nucleic acids.

1969 • 100 citations

Subcutaneous sarcoma as an index of carcinogenic potency

1966 • 99 citations

The Hydroxylation of the Carcinogen 2-Acetylaminofluorene by Rat Liver: Stimulation by Pretreatment in Vivo with 3-Methylcholanthrene

1960 • 98 citations

N-Benzoyloxy-N-methyl-4-aminoazobenzene: its carcinogenic activity in the rat and its reactions with proteins and nucleic acids and their constituents in vitro.

1967 • 98 citations

Alkylation as the Mechanism by which the Hepatotoxic Pyrrolizidine Alkaloids Act on Cell Nuclei

1962 • 97 citations

Mutagenicity of two potent carcinogens, dimethylnitrosamine and diethylnitrosamine, in Neurospora crassa

1966 • 92 citations

Transcriptional controls in developing bacteriophages

1969 • 91 citations

Specificity of Chemical Mutagenesis

1963 • 89 citations

Mutagenicity of Cycasin Aglycone (Methylazoxymethanol), a Naturally Occurring Carcinogen

1966 • 87 citations

Cirrhosis and Carcinoma of the Liver in Male Rats Given Subcutaneous Carbon Tetrachloride

1970 • 85 citations

Metabolism of polycyclic compounds. 24. The metabolism of benz[α]anthracene

1964 • 84 citations

INDUCTION OF MUTATIONS IN TRANSFORMING DNA BY HYDROXYLAMINE

1962 • 81 citations

Neoplasms in Female Fischer Rats Following Intraperitoneal Injection of Methylazoxymethanol<xref ref-type="fn" rid="FN1">1</xref><xref ref-type="fn" rid="FN3">3</xref>

1966 • 78 citations

Relative reactivities for monofunctional nitrogen mustard alkylation of nucleic acid components

1968 • 78 citations

The carcinogenic activities in mice of compounds related to benz[a]anthracene

1967 • 77 citations

Further Experiments on Implantation of Materials into the Urinary Bladder of Mice

1964 • 76 citations

Further Tests for Tumour-Initiating Activity: N,N-DI-(2-Chloroethyl)-P-Aminophenylbutyric Acid (CB1348) as an Initiator of Skin Tumour Formation in the Mouse

1956 • 74 citations

CARCINOGENESIS AND INHIBITION OF THE WALKER 256 TUMOR IN THE RAT BY TRANS-4-ACETYLAMINOSTILBENE, ITS N-HYDROXY METABOLITE, AND RELATED COMPOUNDS.

1964 • 73 citations

Induction of Rat Kidney Tumours by Ethyl Methanesulphonate and Nervous Tissue Tumours by Methyl Methanesulphonate and Ethyl Methanesulphonate

1969 • 69 citations

3-Methylmercapto-N-methyl-4-aminoazobenzene: An alkaline-degradation product of a labile protein-bound dye in the livers of rats fed N,N-dimethyl-4-aminoazobenzene

1965 • 69 citations

Metabolism of polycyclic compounds. 21. The metabolism of phenanthrene in rabbits and rats: dihydrodihydroxy compounds and related glucosiduronic acids

1962 • 69 citations

The carcinogenicity of compounds related to 2-acetylaminofluorene. III. Aminobiphenyl and benzidine derivatives.

1956 • 68 citations

Gene elimination in carcinogenesis: reinterpretation of the somatic mutation theory.

1970 • 66 citations

Repair of radiation-induced damage to chromosomes

1969 • 66 citations

Studies on the molecular mechanism of hydrocarbon carcinogenesis

1964 • 66 citations

Nucleophilic substitution on carcinogenic N-acetoxy-N-arylacetamides.

1970 • 65 citations

Reactions in vitro of some tissue nucleophiles with the glucuronide of the carcinogen N-hydroxy-2-acetylaminofluorene.

1968 • 64 citations

Low Carcinogenicity of the K-Region Epoxides of 7-Methylbenz(a)-anthracene and Benz (a) anthracene in the Mouse and Rat.

1967 • 64 citations

The carcinogenic and mutagenic properties of N-hydroxy-aminonaphthalenes.

1968 • 64 citations

The Role of Conformation in Chemical Mutagenesis

1969 • 61 citations

Alkylation of Rat Liver Nucleic Acids Not Related to Carcinogenesis by <italic>N</italic>-Nitrosamines<xref ref-type="fn" rid="FN2">2</xref><xref ref-type="fn" rid="FN3">3</xref>

1969 • 58 citations

Mutationsauslösung beiDrosophila durch Äthylurethan

1948 • 58 citations

Aflatoxin carcinogenesis: Inhibition of liver cancer induction in hypophysectomized rats

1969 • 57 citations

LIVER DISEASE AND "NATURAL" HEPATOTOXINS.

1963 • 56 citations

METABOLISM OF POLYCYCLIC COMPOUNDS. THE METABOLISM OF 9,10-EPOXY-9,10-DIHYDROPHENANTHRENE IN RATS

1965 • 55 citations

Interlocus Specificity for Chemical Mutagens in Aspergillus nidulans

1966 • 53 citations

N-Hydroxylation of 2-Acetylaminofluorene in the Rabbit

1962 • 50 citations

TOXIC AND CARCINOGENIC ALKYLATING AGENTS FROM CYCADS

1969 • 50 citations

IN VIVO REACTIONS OF β‐PROPIOLACTONE

1969 • 50 citations

Studies on the incorporation of L-ethionine-ethyl-l-14C into the transfer RNA of rat liver.

1969 • 48 citations

Difference in binding of 2-acetylaminofluorene to rat liver deoxyribonucleic acid and ribosomal ribonucleic acid in vivo

1968 • 48 citations

The in vivo binding of beta-propiolactone to mouse skin DNA, RNA, and protein.

1968 • 46 citations

Biliary excretion of the O-glucuronide of N-hydroxy-2-acetylamino-fluorene by the rat and rabbit.

1967 • 45 citations

Interaction between ethionine and rat liver ribonucleic acid and protein in vivo.

1967 • 44 citations

One electron transfer oxidation of 7,12-dimethylbenz[.alpha.]anthracene, a model for the metabolic activation of carcinogenic hydrocarbons

1967 • 43 citations

MUTAGENICITY OF ALKYLATING CARCINOGENS*

1969 • 43 citations

Synthesis of the O-glucuronide of N-2-fluorenylhydroxylamine. Reaction with nucleic acids and with guanosine 5'-monophosphate

1970 • 43 citations

Induction With Carbon Tetrachloride of Liver-Cell Carcinomas in Hamsters<xref ref-type="fn" rid="FN1">2</xref><xref ref-type="fn" rid="FN2">3</xref>

1961 • 43 citations

In vivo Interaction of 4-Nitroquinoline-l-oxide and its Derivatives with DNA

1967 • 43 citations

Tumor-promoting agents from Croton tiglium L. and their mode of action.

1968 • 43 citations

A comparison of the oncogenicities of 3-hydroxyxanthine, guanine 3-N-oxide, and some related compounds.

1970 • 42 citations

Reaction of urethane with nucleic acids in vivo

1969 • 42 citations

Potential Carcinogenic Hazards from Drugs

1967 • 42 citations

N-hydroxy metabolites of 2-acetylaminophenanthrene and 7-fluoro-2-acetylaminofluorene as proximate carcinogens in the rat.

1966 • 41 citations

Mutagenic Action of Mitomycin C on Escherichia coli

1960 • 41 citations

Reactivity of the diacetyl derivative of the carcinogen 4-hydroxyaminoquinoline-1-oxide with DNA, RNA, and other nucleophiles

1968 • 41 citations

Reaction of the glucuronide of the carcinogen N-hydroxy-2-acetylaminofluorene with nucleic acids

1969 • 40 citations

Bladder Cancer. A Symposium

1968 • 40 citations

Genetic Analysis of the Induction of Tumors by Methylcholanthrene

1945 • 39 citations

Interaction of a carcinogen, 4-hydroxyaminoquinoline-1-oxide with nucleic acids

1967 • 39 citations

Purine N-oxides. XVI. Oncogenic derivatives of xanthine and guanine.

1965 • 39 citations

THE MUTAGENICITY AND INITIATING ACTIVITY OF SOME AROMATIC AMINE METABOLITES*

1969 • 37 citations

The mutagenic activity of the pyrrolizidine alkaloid heliotrine in Drosophila melanogaster II. Chromosome rearrangements

1969 • 37 citations

Mutations and loss of transforming activity of Bacillus subtilis DNA after reaction with esters of carcinogenic N-hydroxy aromatic amides.

1970 • 35 citations

Structures of polar dyes derived from the liver proteins of rats fed N-methyl-4-aminoazobenzene. III. Tyrosine and homocysteine sulfoxide polar dyes

1969 • 34 citations

Chemical Carcinogenesis and Cancers

1965 • 34 citations

Oncogenic Purine Derivatives: Evidence for a Possible Proximate Oncogen

1970 • 33 citations

The binding of beta-propiolactone and some related alkylating agents to DNA, RNA, and protein of mouse skin; relation between tumor-initiating power of alkylating agents and their binding to DNA.

1968 • 32 citations

THE MUTAGENICITY OF SOME CARCINOGENIC COMPOUNDS FOR ESCHERICHIA COLI

1954 • 32 citations

Mutagenic Action of Aflatoxin B1 on Transforming DNA and Inhibition of DNA Template Activity in vitro

1970 • 32 citations

Structures of polar dyes derived from the liver proteins of rats fed N-methyl-4-aminoazobenzene. II. Identity of synthetic 3-(homocystein-S-yl)-N-methyl-4-aminoazobenzene with the major polar dye P2b

1968 • 31 citations

Pyrrolizidine alkaloids

1989 • 31 citations

The mutagenic activity of heliotrine in drosophila

1966 • 30 citations

Tumorigenicity of acridine orange.

1969 • 30 citations

Genetic effects of polynuclear hydrocarbons: Induction of mitotic gene conversion

1969 • 30 citations

N-Hydroxylation in Aminostilbene Carcinogenesis

1965 • 30 citations

Possible role of the glucuronide conjugate in the biochemical mechanism op binding of the carcinogen N-hydroxy-2-acetylaminofluorene to rat-liver deoxyribonucleic acid in vivo

1969 • 29 citations

Inhibition of the toxicity and carcinogenicity of N-2-fluorenylacetamide by acetanilide

1968 • 28 citations

Propanesultone, a Potent Carcinogen

1968 • 27 citations

Peroxide induced binding of hydrocarbons to DNA

1968 • 26 citations

Mutagenicity in yeast of nitroquinolines and related compounds

1969 • 26 citations

Purine n-oxides XXIV. The preparation of 8-substituted xanthines and guanines by a nucleophilic displacement of a 3-substituent

1969 • 26 citations

REACTIONS WITH PURINES AND PYRIMIDINES*

1969 • 26 citations

Ausscheidung freien und konjugierten Sulfates bei Ratte und Menschen nach Verabreichung von N-Acetyl-p-Aminophenol

1968 • 26 citations

The Reaction of Liver Proteins with a Metabolite of Carbon Tetrachloride

1966 • 26 citations

On the Structure of the Glucuronide of N-Hydroxy-2-acetylaminofluorene

1965 • 25 citations

Ethylation in vivo of purines in rat-liver tRNA by L-ethionine

1968 • 24 citations

Tumor initiation in mouse skin by certain esters of methanesulfonic acid.

1957 • 24 citations

Influence of mutagens on the initiation of skin carcinogenesis

1964 • 24 citations

Incorporation in vivo of methionine and ethionine into and the methylation and ethylation of rat liver nuclear proteins

1968 • 24 citations

XIII.—Tests of Carcinogenic Substances in Relation to the Production of Mutations in Drosophila melanogaster

1940 • 23 citations

Carcinogene Wirkung von Phenyl-nitroso-harnstoff

1968 • 23 citations

Mutation in Tobacco Mosaic Virus induced by a New Carcinogen, 4-Nitroquinolme N-Oxide

1961 • 21 citations

Comparative Carcinogenicity of 4-Nitroquinoline 1-oxide and 4-Hydroxyaminoquinoline 1-oxide in 3 Strains of Mice

1965 • 20 citations

Production of respiration-deficient mutants in yeast by a carcinogen, 4-nitroquinoline 1-oxide

1969 • 20 citations

A failure to detect any mutagenic action of urethane in the mouse

1967 • 19 citations

CARCINOGENIC MUTAGENS

1958 • 19 citations

Bladder cancer : a symposium

1967 • 18 citations

Hydrolysis of Cycasin by -D-Glucosidase in Skin of Newborn Rats

1968 • 17 citations

Methylation of ribonucleic acid and deoxyribonucleic acid and tumour induction in livers of hypophysectomized rats treated with dimethylnitrosamine

1968 • 17 citations

Mutagenic alkylating agents as growth inhibitors and carcinogens

1969 • 17 citations

Uracil Mustard: A Potent Inducer of Lung Tumors in Mice

1965 • 16 citations

Specific Genetic Deletions by a Carcinogenic Hydrocarbon in Drosophila

1969 • 16 citations

The Mitomycins and Porfiromycins

1967 • 16 citations

EVALUATION OF THE CARCINOGENICITY OF AMINOFLUORENOLS BY IMPLANTATION INTO THE BLADDER OF THE MOUSE.

1963 • 15 citations

Tumor incidence and lethal mutation rate in Drosophila treated with 20-methylcholanthrene.

1952 • 14 citations

Induction of mutations in habrobracon sperm with mitomycin C

1969 • 12 citations

The effect of carbamates on Bacillus subtilis

1967 • 10 citations

THE RELATION BETWEEN REPAIR OF RADIATION DAMAGE AND MUTATION INDUCTION*

1968 • 9 citations

Nucleophile Substitution carcinogener und nichtcarcinogener Kohlenwasserstoffe über Elektronen‐Donator‐Acceptor‐Komplexe

1969 • 6 citations

Mutation rate following treatment of Neurospora with 20-methylcholanthrene and I, 2,5,6-dibenzanthracene in tween-80.

1954 • 5 citations

On Potential Carcinogenicity of Some Hydrazine Derivatives Used as Drugs

1967 • 4 citations

[Cancer experimental et mutations somatiques].

1953 • 1 citations