Disruption of thiol homeostasis and nitrosative stress in the cerebrospinal fluid of patients with active multiple sclerosis: evidence for a protective role of acetylcarnitine.

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Short-Term Effects of Nose-Only Cigarette Smoke Exposure on Glutathione Redox Homeostasis, Cytochrome P450 1A1/2 and Respiratory Enzyme Activities in Mice Tissues

2013 • 47,043 citations

Measurement of protein using bicinchoninic acid

1985 • 17,516 citations

Rating neurologic impairment in multiple sclerosis

1983 • 14,011 citations

New diagnostic criteria for multiple sclerosis: Guidelines for research protocols

1983 • 7,404 citations

New Multiple Sclerosis Phenotypic Classification

2014 • 4,124 citations

Defining the clinical course of multiple sclerosis

1996 • 3,606 citations

Nitric Oxide Synthases: Properties and Catalytic Mechanism

1995 • 1,275 citations

Lipid peroxidation and protein oxidation in Alzheimer’s disease brain: potential causes and consequences involving amyloid β-peptide-associated free radical oxidative stress 1,2 1Guest Editors: Mark A. Smith and George Perry 2This article is part of a series of reviews on “Causes and Consequences of Oxidative Stress in Alzheimer’s Disease.” The full list of papers may be found on the homepage of the journal.

2002 • 961 citations

Proteomic identification of oxidatively modified proteins in alzheimer’s disease brain. part I: creatine kinase BB, glutamine synthase, and ubiquitin carboxy-terminal hydrolase L-1

2002 • 582 citations

Demyelination: The Role of Reactive Oxygen and Nitrogen Species

1999 • 579 citations

Measurement of nitrate and nitrite in biological samples using nitrate reductase and Griess reaction

1996 • 501 citations

Activation of the inducible form of nitric oxide synthase in the brains of patients with multiple sclerosis.

1995 • 464 citations

Plasma glutathione and glutathione disulfide in the rat: regulation and response to oxidative stress.

1983 • 463 citations

Hydroperoxide-initiated chemiluminescence: An assay for oxidative stress in biopsies of heart, liver, and muscle

1991 • 446 citations

[25] Nitric-oxide synthase assays

1994 • 429 citations

Oxygen Radicals in Biological Systems

1984 • 406 citations

Nutritional approaches to combat oxidative stress in Alzheimer’s disease

2002 • 399 citations

Immunological Aspects of Experimental Allergic Encephalomyelitis and Multiple Sclerosis

1995 • 381 citations

Peroxynitrite-induced luminol chemiluminescence

1993 • 371 citations

The pathophysiology of multiple sclerosis⋮ the mechanisms underlying the production of symptoms and the natural history of the disease

1999 • 326 citations

Caffeic Acid Phenethyl Ester and Curcumin: A Novel Class of Heme Oxygenase-1 Inducers

2002 • 322 citations

NO synthase and NO-dependent signal pathways in brain aging and neurodegenerative disorders: the role of oxidant/antioxidant balance.

2000 • 287 citations

Isothioureas: potent inhibitors of nitric oxide synthases with variable isoform selectivity

1995 • 274 citations

Mitochondrial involvement in brain function and dysfunction: relevance to aging, neurodegenerative disorders and longevity.

2001 • 263 citations

Peroxynitrite formation within the central nervous system in active multiple sclerosis

1998 • 201 citations

Activation of murine microglial cell lines by lipopolysaccharide and interferon‐γ causes NO‐mediated decreases in mitochondrial and cellular function

2001 • 191 citations

Deoletion of brain glutathione is accompanied by impaired micochondrial function and decreased N-acetyl aspartate concentration

1995 • 186 citations

Vitamin E and Neurodegenerative Disorders Associated with Oxidative Stress

2002 • 176 citations

Evidence for the production of peroxynitrite in inflammatory CNS demyelination

1997 • 168 citations

Nitric oxide synthase is present in the cerebrospinal fluid of patients with active multiple sclerosis and is associated with increases in cerebrospinal fluid protein nitrotyrosine and S‐nitrosothiols and with changes in glutathione levels

2002 • 160 citations

Astrocytes and microglia express inducible nitric oxide synthase in mice with experimental allergic encephalomyelitis

1997 • 137 citations

Nitric oxide toxicity in CNS white matter: an in vitro study using rat optic nerve

2002 • 115 citations

The CSF proteins: A biochemical approach

1988 • 112 citations

Nitric oxide synthase induction in astroglial cell cultures: Effect on heat shock protein 70 synthesis and oxidant/antioxidant balance

2000 • 110 citations

Elevation of brain glutathione by γ‐glutamylcysteine ethyl ester protects against peroxynitrite‐induced oxidative stress

2002 • 108 citations

Effects of 1‐Methyl‐4‐Phenylpyridinium on Isolated Rat Brain Mitochondria: Evidence for a Primary Involvement of Energy Depletion

1994 • 104 citations

Regional distribution of heme oxygenase, HSP70, and glutathione in brain: Relevance for endogenous oxidant/antioxidant balance and stress tolerance

2002 • 99 citations

Stress proteins and SH-groups in oxidant-induced cell damage after acute ethanol administration in rat

1996 • 98 citations

Reaction of peroxynitrite with carbon dioxide: intermediates and determination of the yield of CO3 •– and NO2 •

2001 • 97 citations

Stress Proteins and SH-Groups in Oxidant-Induced Cellular Injury After Chronic Ethanol Administration in Rat

1998 • 96 citations

Insights into the Immunopathogenesis of Multiple Sclerosis

2002 • 88 citations

Mitochondrial Decay in Aging: Reversal through Supplementation of Acetyl-l-Carnitine and N-tert-Butyl-alpha-phenyl-nitronea

1998 • 88 citations

Multiple Sclerosis

1997 • 87 citations

Cerebrospinal fluid and serum nitric oxide metabolites in patients with multiple sclerosis

1998 • 80 citations

Changes in cerebrospinal fluid levels of malondialdehyde and glutathione reductase activity in multiple sclerosis.

1994 • 71 citations

Attenuation by acetyl-L-carnitine of neurological damage and biochemical derangement following brain ischemia and reperfusion.

1999 • 69 citations

Molecular Chaperones and Their Roles in Neural Cell Differentiation

2002 • 65 citations

The effect of L-carnitine and acetyl-L-carnitine on the disappearance of DNA single-strand breaks in human peripheral blood lymphocytes

1993 • 58 citations

Increased cerebrospinal fluid and plasma levels of ultraweak chemiluminescence are associated with changes in the thiol pool and lipid-soluble fluorescence in multiple sclerosis: the pathogenic role of oxidative stress.

1998 • 40 citations

Glutathione peroxidase activity in various types of blood cells in multiple sclerosis

2009 • 31 citations

Formation of Propionate After Short-Term Ethanol Treatment and Its Interaction with the Carnitine Pool in Rat

1999 • 30 citations

Real-time measurement of nitric oxide production in rat brain by the combination of luminol-H2O2 chemiluminescence and microdialysis

1997 • 29 citations

Effects of L-carnitine on the formation of fatty acid ethyl esters in brain and peripheral organs after short-term ethanol administration in rat.

1999 • 29 citations

Effects of acetyl-L-carnitine on the formation of fatty acid ethyl esters in brain and peripheral organs after short-term ethanol administration in rat.

2001 • 16 citations

Effects of levo-acetylcarnitine on second motoneuron survival after axotomy

1995 • 15 citations

LIPID PEROXIDATION AND PROTEIN OXIDATION IN ALZHEIMER'S DISEASE BRAIN: POTENTIAL CAUSES AND CONSEQUENCES INVOLVING AMYLOID -PEPTIDE-ASSOCIATED FREE RADICAL OXIDATIVE STRESS

2002 • 14 citations

T cell-T cell activation in multiple sclerosis

1997 • 10 citations

[Fatty diet and multiple sclerosis].

1997 • 5 citations