Thymocyte Negative Selection Is Mediated by Protein Kinase C- and Ca2+-Dependent Transcriptional Induction of Bim

T cell receptor antagonist peptides induce positive selection

1994 • 2,818 citations

The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C

1991 • 2,499 citations

Neuronal specification in the spinal cord: inductive signals and transcriptional codes

2000 • 2,051 citations

Selective inhibition of protein kinase C isozymes by the indolocarbazole Gö 6976

1993 • 1,589 citations

Positive and Negative Selection of T Cells

2003 • 1,547 citations

Proapoptotic Bcl-2 Relative Bim Required for Certain Apoptotic Responses, Leukocyte Homeostasis, and to Preclude Autoimmunity

1999 • 1,500 citations

Bim: a novel member of the Bcl-2 family that promotes apoptosis

1998 • 1,154 citations

The Proapoptotic Activity of the Bcl-2 Family Member Bim Is Regulated by Interaction with the Dynein Motor Complex

1999 • 1,045 citations

Expression of the pro-apoptotic Bcl-2 family member Bim is regulated by the forkhead transcription factor FKHR-L1

2000 • 983 citations

PKC-θ is required for TCR-induced NF-κB activation in mature but not immature T lymphocytes

2000 • 890 citations

BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes

2002 • 772 citations

Early steps of lymphocyte activation bypassed by synergy between calcium ionophores and phorbol ester

1985 • 753 citations

Defective Thymocyte Maturation in p44 MAP Kinase (Erk 1) Knockout Mice

1999 • 641 citations

FOXO transcription factors directly activate bim gene expression and promote apoptosis in sympathetic neurons

2003 • 635 citations

Inhibition of protein kinase C μ by various inhibitors. Inhibition from protein kinase c isoenzymes

1996 • 633 citations

The role of BH3-only proteins in the immune system

2005 • 608 citations

Activation of the ERK1/2 Signaling Pathway Promotes Phosphorylation and Proteasome-dependent Degradation of the BH3-only Protein, Bim

2003 • 607 citations

T cell killing does not require the formation of a stable mature immunological synapse

2004 • 569 citations

Activated T Cell Death In Vivo Mediated by Proapoptotic Bcl-2 Family Member Bim

2002 • 564 citations

Essential role for ZAP-70 in both positive and negative selection of thymocytes

1995 • 554 citations

Phosphorylation of Bim-EL by Erk1/2 on serine 69 promotes its degradation via the proteasome pathway and regulates its proapoptotic function

2003 • 466 citations

Recruitment of Nck by CD3ϵ Reveals a Ligand-Induced Conformational Change Essential for T Cell Receptor Signaling and Synapse Formation

2002 • 442 citations

Selective requirement for MAP kinase activation in thymocyte differentiation

1995 • 398 citations

Four A6-TCR/Peptide/HLA-A2 Structures that Generate Very Different T Cell Signals Are Nearly Identical

1999 • 366 citations

Impaired Viability and Profound Block in Thymocyte Development in Mice Lacking the Adaptor Protein SLP-76

1998 • 360 citations

Protein Kinase C θ Affects Ca2+ Mobilization and NFAT Activation in Primary Mouse T Cells

2003 • 320 citations

The Role of Erk1 and Erk2 in Multiple Stages of T Cell Development

2005 • 319 citations

Calcium-dependent killing of immature thymocytes by stimulation via the CD3/T cell receptor complex.

1989 • 315 citations

Loss of the Pro-Apoptotic BH3-only Bcl-2 Family Member Bim Inhibits BCR Stimulation–induced Apoptosis and Deletion of Autoreactive B Cells

2003 • 296 citations

Deficiency in Bak and Bax perturbs thymic selection and lymphoid homeostasis

2002 • 293 citations

Identification of Novel Isoforms of the BH3 Domain Protein Bim Which Directly Activate Bax To Trigger Apoptosis

2002 • 287 citations

A Requirement for the Rho-Family GTP Exchange Factor Vav in Positive and Negative Selection of Thymocytes

1997 • 285 citations

Degenerative Disorders Caused by Bcl-2 Deficiency Prevented by Loss of Its BH3-Only Antagonist Bim

2001 • 270 citations

Positive and negative selection invoke distinct signaling pathways.

1996 • 234 citations

Microarray Analysis Uncovers the Induction of the Proapoptotic BH3-only Protein Bim in Multiple Models of Glucocorticoid-induced Apoptosis

2003 • 227 citations

The Influence of the MAPK Pathway on T Cell Lineage Commitment

1997 • 217 citations

Calcineurin B1 Is Essential for Positive but Not Negative Selection during Thymocyte Development

2004 • 216 citations

A motif in the αβ T-cell receptor controls positive selection by modulating ERK activity

2000 • 203 citations

Conversion of an Extracellular Dpp/BMP Morphogen Gradient into an Inverse Transcriptional Gradient

2003 • 181 citations

Defective Central Tolerance Induction in NOD Mice: Genomics and Genetics

2005 • 179 citations

Nerve Growth Factor (NGF) Down-regulates the Bcl-2 Homology 3 (BH3) Domain-only Protein Bim and Suppresses Its Proapoptotic Activity by Phosphorylation

2002 • 177 citations

Disruption of T cell signaling networks and development by Grb2 haploid insufficiency

2001 • 165 citations

Generalized Resistance to Thymic Deletion in the NOD Mouse

2004 • 157 citations

An activated Ick transgene promotes thymocyte development in rag-1 mutant mice

1994 • 157 citations

Induction of the Early Growth Response (Egr) Family of Transcription Factors during Thymic Selection

1997 • 141 citations

Gene structure, alternative splicing, and chromosomal localization of pro-apoptotic Bcl-2 relative Bim

2001 • 140 citations

Tec Family Kinases Modulate Thresholds for Thymocyte Development and Selection

2000 • 131 citations

T cell receptor engagement by peptide–MHC ligands induces a conformational change in the CD3 complex of thymocytes

2005 • 126 citations

Molecular cloning and characterization of six novel isoforms of human Bim, a member of the proapoptotic Bcl‐2 family¹

2001 • 91 citations

Mutation of the phospholipase C-γ1–binding site of LAT affects both positive and negative thymocyte selection

2005 • 81 citations

Ternary complex factor SAP-1 is required for Erk-mediated thymocyte positive selection

2004 • 79 citations

In Vivo Calcium Elevations in Thymocytes with T Cell Receptors That Are Specific for Self Ligands

1992 • 72 citations

The CD3ε Proline-Rich Sequence, and Its Interaction with Nck, Is Not Required for T Cell Development and Function

2005 • 70 citations

Signaling by the kinase MINK is essential in the negative selection of autoreactive thymocytes

2004 • 54 citations

Degree of TCR Internalization and Ca2+ Flux Correlates with Thymocyte Selection

1998 • 50 citations

Commitment to the CD4 Lineage Mediated by Extracellular Signal-Related Kinase Mitogen-Activated Protein Kinase and Lck Signaling

1999 • 49 citations

Generalized Resistance to Thymic Deletion in the NOD MouseA Polygenic Trait Characterized by Defective Induction of Bim

2004 • 48 citations

Phosphorylation of the pro-apoptotic protein Bim in lymphocytes is associated with protection from apoptosis

2003 • 47 citations

Receptor Avidity and Costimulation Specify the Intracellular Ca2+ Signaling Pattern in Cd4+Cd8+ Thymocytes

1999 • 45 citations

A role for calcium influx in setting the threshold for CD4+CD8+ thymocyte negative selection.

1996 • 44 citations

Regulation of Bim by TCR Signals in CD4/CD8 Double-Positive Thymocytes

2005 • 26 citations

Early Growth Response (Egr)-1 Gene Induction in the Thymus in Response to TCR Ligation During Early Steps in Positive Selection Is Not Required for CD8 Lineage Commitment

2000 • 24 citations

Protein kinase C? is dispensable for TCR/CD3-signaling

2004 • 23 citations

Protein kinase C beta is dispensable for TCR-signaling

2004 • 18 citations

The calcium‐independent protein kinase C participates in an early process of CD3/CD28‐mediated induction of thymocyte apoptosis

2000 • 13 citations