Affinity purification of ubiquitin-protein ligase on immobilized protein substrates. Evidence for the existence of separate NH2-terminal binding sites on a single enzyme.

In Vivo Half-Life of a Protein Is a Function of Its Amino-Terminal Residue

1986 • 1,942 citations

A Multiubiquitin Chain Is Confined to Specific Lysine in a Targeted Short-Lived Protein

1989 • 1,463 citations

Components of ubiquitin-protein ligase system. Resolution, affinity purification, and role in protein breakdown.

1983 • 1,105 citations

ATP-dependent conjugation of reticulocyte proteins with the polypeptide required for protein degradation.

1980 • 530 citations

Ubiquitin-mediated protein degradation.

1988 • 453 citations

Ubiquitin-Mediated Pathways for Intracellular Proteolysis

1987 • 409 citations

Antibodies to two major chicken heat shock proteins cross-react with similar proteins in widely divergent species.

1982 • 316 citations

"Covalent affinity" purification of ubiquitin-activating enzyme.

1982 • 310 citations

Methionine or not methionine at the beginning of a protein

1985 • 308 citations

Occurrence of a polyubiquitin structure in ubiquitin-protein conjugates

1985 • 263 citations

The Ubiquitin Pathway for the Degradation of Intracellular Proteins

1986 • 213 citations

Specificity of cotranslational amino-terminal processing of proteins in yeast

1987 • 204 citations

Ubiquitin-aldehyde: a general inhibitor of ubiquitin-recycling processes.

1987 • 189 citations

The protein substrate binding site of the ubiquitin-protein ligase system.

1986 • 178 citations

A multicomponent system that degrades proteins conjugated to ubiquitin. Resolution of factors and evidence for ATP-dependent complex formation.

1988 • 161 citations

Specificity of binding of NH2-terminal residue of proteins to ubiquitin-protein ligase. Use of amino acid derivatives to characterize specific binding sites.

1988 • 144 citations

Role of arginine-tRNA in protein degradation by the ubiquitin pathway

1987 • 142 citations

Detection, resolution and nomenclature of multiple ubiquitin carboxyl-terminal esterases from bovine calf thymus

1989 • 129 citations

Cotranslational amino-terminal processing of cytosolic proteins. Cell-free expression of site-directed mutants of human hemoglobin.

1988 • 123 citations

Purification and characterization of arginyl-tRNA-protein transferase from rabbit reticulocytes. Its involvement in post-translational modification and degradation of acidic NH2 termini substrates of the ubiquitin pathway.

1988 • 75 citations

Binding Sites of Ubiquitin-Protein Ligase

1989 • 70 citations

Multiple forms of ubiquitin-protein ligase, binding of activated ubiquitin to protein substrates

1986 • 25 citations

Inhibition of ubiquitin-dependent proteolysis by non-ubiquitinatable proteins.

1986 • 16 citations