Once and only once upon a time: specifying and regulating origins of DNA replication in eukaryotic cells.

Checkpoints: Controls That Ensure the Order of Cell Cycle Events

1989 • 3,036 citations

On the Regulation of DNA Replication in Bacteria

1963 • 1,441 citations

ATP-dependent recognition of eukaryotic origins of DNA replication by a multiprotein complex

1992 • 1,279 citations

The localization of replication origins on ARS plasmids in S. cerevisiae

1987 • 1,051 citations

On the mechanism of DNA replication in mammalian chromosomes

1968 • 950 citations

The B-type cyclin kinase inhibitor p40SIC1 controls the G1 to S transition in S. cerevisiae

1994 • 902 citations

Mammalian Cell Fusion : Studies on the Regulation of DNA Synthesis and Mitosis

1970 • 759 citations

Creative blocks: cell-cycle checkpoints and feedback controls

1992 • 686 citations

A Yeast Chromosomal Origin of DNA Replication Defined by Multiple Functional Elements

1992 • 634 citations

Formation in Vitro of Sperm Pronuclei and Mitotic Chromosomes Induced by Amphibian Ooplasmic Components

1983 • 630 citations

Initiation of DNA replication in nuclei and purified DNA by a cell-free extract of Xenopus eggs

1986 • 622 citations

A role for the nuclear envelope in controlling DNA replication within the cell cycle

1988 • 605 citations

Two steps in the assembly of complexes at yeast replication origins in vivo

1994 • 566 citations

CLB5 and CLB6, a new pair of B cyclins involved in DNA replication in Saccharomyces cerevisiae.

1993 • 521 citations

ANIMAL VIRUS DNA REPLICATION

1989 • 520 citations

The Units of DNA Replication in Drosophila melanogaster Chromosomes

1974 • 518 citations

Evidence that the G1-S and G2-M transitions are controlled by different cdc2 proteins in higher eukaryotes

1991 • 493 citations

The role of CDC28 and cyclins during mitosis in the budding yeast S. cerevisiae

1991 • 463 citations

A model for initiation at origins of DNA replication

1988 • 452 citations

The fission yeast cdc18+ gene product couples S phase to START and mitosis

1993 • 446 citations

The in vivo replication origin of the yeast 2μm plasmid

1987 • 437 citations

Yeast Origin Recognition Complex Functions in Transcription Silencing and DNA Replication

1993 • 435 citations

The roles of Drosophila cyclins A and B in mitotic control

1990 • 429 citations

MUTANTS OF S. CEREVISIAE DEFECTIVE IN THE MAINTENANCE OF MINICHROMOSOMES

1984 • 419 citations

Isolation of ORC6 , a Component of the Yeast Origin Recognition Complex by a One-Hybrid System

1993 • 416 citations

Binding and unwinding—How T antigen engages the SV40 origin of DNA replication

1990 • 404 citations

Cdc6 is an unstable protein whose de novo synthesis in G1 is important for the onset of S phase and for preventing a ‘reductional’ anaphase in the budding yeast Saccharomyces cerevisiae.

1995 • 402 citations

A common set of conserved motifs in a vast variety of putative nucleic acid-dependent ATPases including MCM proteins involved in the initiation of eukaryotic DNA replication

1993 • 400 citations

Sequential gene function in the initiation of Saccharomyces cerevisiae DNA synthesis

1974 • 394 citations

Temporal order of S phase and mitosis in fission yeast is determined by the state of the p34cdc2-mitotic B cyclin complex

1994 • 393 citations

CLB5: a novel B cyclin from budding yeast with a role in S phase.

1992 • 391 citations

The Xenopus Cdc6 Protein Is Essential for the Initiation of a Single Round of DNA Replication in Cell-Free Extracts

1996 • 387 citations

Protein-DNA interactions at a yeast replication origin

1992 • 380 citations

COLD-SENSITIVE CELL-DIVISION-CYCLE MUTANTS OF YEAST: ISOLATION, PROPERTIES, AND PSEUDOREVERSION STUDIES

1982 • 372 citations

S-phase-promoting cyclin-dependent kinases prevent re-replication by inhibiting the transition of replication origins to a pre-replicative state

1995 • 366 citations

Regulated replication of DNA microinjected into eggs of Xenopus laevis

1980 • 362 citations

An essential role for the Cdc6 protein in forming the pre-replicative complexes of budding yeast

1996 • 362 citations

Purification of an MCM-containing complex as a component of the DNA replication licensing system

1995 • 361 citations

ORC and Cdc6p interact and determine the frequency of initiation of DNA replication in the genome

1995 • 357 citations

Regulation of progression through the Gl phase of the cell cycle by the rum1+ gene

1994 • 356 citations

Initiation Of Eukaryotic DNA Replication In Vitro

1989 • 343 citations

Involvement of p34cdc2 in establishing the dependency of S phase on mitosis

1991 • 340 citations

Cdk inhibitors: on the threshold of checkpoints and development

1994 • 326 citations

A group of interacting yeast DNA replication genes.

1991 • 325 citations

Transition in Specification of Embryonic Metazoan DNA Replication Origins

1995 • 321 citations

Origin Recognition Complex (ORC) in Transcriptional Silencing and DNA Replication in S. cerevisiae

1993 • 314 citations

Characterization of four B-type cyclin genes of the budding yeast Saccharomyces cerevisiae.

1992 • 310 citations

A cyclin B homolog in S. cerevisiae: Chronic activation of the Cdc28 protein kinase by cyclin prevents exit from mitosis

1991 • 310 citations

Cyclin Ubiquitination: The destructive end of mitosis

1995 • 304 citations

Sequential function of gene products relative to DNA synthesis in the yeast cell cycle

1976 • 302 citations

Activation of S-phase-promoting CDKs in late G1 defines a "point of no return" after which Cdc6 synthesis cannot promote DNA replication in yeast.

1996 • 293 citations

Cyclin-B homologs in Saccharomyces cerevisiae function in S phase and in G2.

1992 • 281 citations

Identification of the yeast MCM3-related protein as a component of xenopus DNA replication licensing factor

1995 • 280 citations

Replication structure of the human & beta;-globin gene domain

1993 • 277 citations

A quantitative model for the cdc2 control of S phase and mitosis in fission yeast

1996 • 267 citations

p65cdc18 Plays a major role controlling the initiation of DNA replication in fission yeast

1995 • 259 citations

The multidomain structure of Orc1 p reveals similarity to regulators of DNA replication and transcriptional silencing

1995 • 259 citations

Interaction between the Origin Recognition Complex and the Replication Licensing Systemin Xenopus

1996 • 255 citations

Cell Cycle Regulation of the Yeast Cdc7 Protein Kinase by Association With the Dbf4 Protein†

1993 • 250 citations

Point of No Return

1949 • 247 citations

Conserved Initiator Proteins in Eukaryotes

1995 • 246 citations

Cell cycle-regulated nuclear localization of MCM2 and MCM3, which are required for the initiation of DNA synthesis at chromosomal replication origins in yeast.

1993 • 233 citations

Yeast origin recognition complex is involved in DNA replication and transcriptional silencing

1993 • 231 citations

Linkage of Replication to Start by the Cdk Inhibitor Sic1

1996 • 230 citations

Autoradiography of HeLa cell DNA

1966 • 221 citations

MCM3 complex required for cell cycle regulation of DNA replication in vertebrate cells

1995 • 220 citations

Distinct modes of cyclin E/cdc2c kinase regulation and S-phase control in mitotic and endoreduplication cycles of Drosophila embryogenesis.

1995 • 220 citations

Participation of the Human β-Globin Locus Control Region in Initiation of DNA Replication

1995 • 217 citations

Interaction of Dbf4, the Cdc7 Protein Kinase Regulatory Subunit, with Yeast Replication Origins in Vivo

1994 • 213 citations

Fission yeast minichromosome loss mutants mis cause lethal aneuploidy and replication abnormality.

1994 • 211 citations

A cdc2-like protein is involved in the initiation of DNA replication in Xenopus egg extracts

1990 • 209 citations

Role for a Xenopus Orc2-related protein in controlling DNA replication

1996 • 207 citations

The origin recognition complex in silencing, cell cycle progression, and DNA replication.

1995 • 204 citations

The origin recognition complex interacts with a bipartite DNA binding site within yeast replicators.

1995 • 204 citations

Origins of DNA replication in metazoan chromosomes.

1993 • 203 citations

Early events in DNA replication require cyclin E and are blocked by p21CIP1.

1995 • 197 citations

Mcm2 and Mcm3, two proteins important for ARS activity, are related in structure and function.

1991 • 196 citations

p25rum1 orders S phase and mitosis by acting as an inhibitor of the p34cdc2 mitotic kinase

1995 • 190 citations

The origin recognition complex has essential functions in transcriptional silencing and chromosomal replication.

1995 • 187 citations

SV40 DNA replication.

1988 • 184 citations

Initiation complex assembly at budding yeast replication origins begins with the recognition of a bipartite sequence by limiting amounts of the initiator, ORC.

1995 • 179 citations

The role of MCM/P1 proteins in the licensing of DNA replication.

1996 • 176 citations

DNA replication initiates at multiple sites on plasmid DNA in Xenopus egg extracts

1992 • 154 citations

A question of time: Replication origins of eukaryotic chromosomes

1992 • 153 citations

A Drosophila Homolog of the Yeast Origin Recognition Complex

1995 • 152 citations

The cyclin-dependent kinase inhibitor p40SIC1 imposes the requirement for Cln G1 cyclin function at Start.

1996 • 151 citations

Transcription interferes with elements important for chromosome maintenance in Saccharomyces cerevisiae.

1988 • 148 citations

Addition of extra origins of replication to a minichromosome suppresses its mitotic loss in cdc6 and cdc14 mutants of Saccharomyces cerevisiae.

1992 • 145 citations

Functional conservation of multiple elements in yeast chromosomal replicators.

1994 • 145 citations

Both cyclin A and cyclin E have S-phase promoting (SPF) activity in Xenopus egg extracts

1996 • 142 citations

Cell cycle-regulated nuclear import and export of Cdc47, a protein essential for initiation of DNA replication in budding yeast.

1995 • 140 citations

Plasmid replication inXenopuseggs and egg extracts: a 2D gel electrophoretic analysis

1992 • 135 citations

Interaction of Cdc2 and CdclS with a fission yeast ORC2-like protein

1996 • 131 citations

Fission yeastcdc21⁺belongs to a family of proteins involved in an early step of chromosome replication

1992 • 131 citations

Autoradiography of chromosomal DNA fibers from Chinese hamster cells.

1966 • 130 citations

cdc18+ regulates initiation of DNA replication in Schizosaccharomyces pombe.

1996 • 129 citations

Cell cycle checkpoints, genetic instability and cancer.

1993 • 126 citations

Domain B of ARS307 contains two functional elements and contributes to chromosomal replication origin function.

1994 • 123 citations

The nuclear envelope prevents reinitiation of replication by regulating the binding of MCM3 to chromatin in Xenopus egg extracts

1995 • 119 citations

Mammalian cell fusion

1974 • 112 citations

The B-type cyclin kinase inhibitor p40(SiC1) Controls the G1 to S transition in S-cerevisiae (vol 79, pg 233, 1994)

1996 • 111 citations

Temperature-sensitive cdc7 mutations of Saccharomyces cerevisiae are suppressed by the DBF4 gene, which is required for the G1/S cell cycle transition.

1992 • 103 citations

The yeast gene, DBF4, essential for entry into S phase is cell cycle regulated

1989 • 101 citations

Orp1, a member of the Cdc18/Cdc6 family of S-phase regulators, is homologous to a component of the origin recognition complex.

1995 • 98 citations

Rum1 and Cdc18 link inhibition of cyclin-dependent kinase to the initiation of DNA replication in Schizosaccharomyces pombe.

1996 • 96 citations

The Saccharomyces cerevisiae CDC6 gene is transcribed at late mitosis and encodes a ATP/GTPase controlling S phase initiation.

1994 • 96 citations

A new pair of B-type cyclins from Saccharomyces cerevisiae that function early in the cell cycle.

1993 • 95 citations

Autonomous Replication in Human Cells of Multimers of Specific Human and Bacterial DNA Sequences

1993 • 87 citations

Multiple DNA Elements in ARS305 Determine Replication Origin Activity in a Yeast Chromosome

1996 • 87 citations

Fission yeast genes nda1+ and nda4+, mutations of which lead to S-phase block, chromatin alteration and Ca2+ suppression, are members of the CDC46/MCM2 family.

1993 • 78 citations

The fission yeast cdc19+ gene encodes a member of the MCM family of replication proteins

1994 • 78 citations

A quantitative model for the cdc2 control of S phase and mitosis in fission yeast

1996 • 69 citations

Characterization of an Essential Orc2p-Associated Factor That Plays a Role in DNA Replication

1996 • 69 citations

Transcription inhibits the replication of autonomously replicating plasmids in human cells.

1994 • 63 citations

DNA replication in cell-free extracts from Drosophila melanogaster.

1991 • 58 citations

Separation of Origin Recognition Complex Functions by Cross-Species Complementation

1995 • 55 citations

Cdc54 belongs to the Cdc46/Mcm3 family of proteins which are essential for initiation of eukaryotic DNA replication

1995 • 41 citations

Both cdc2 and cdk2 promote S phase initiation in Xenopus egg extracts

1995 • 38 citations

Initiation of DNA replication in eukaryotic chromosomes

1981 • 31 citations

Transcription through the yeast origin of replication ARS1 ends at the ABFI binding site and affects extrachromosomal maintenance of minichromosomes

1994 • 30 citations

Characterization of a novel CDC gene (ORC1) partly homologous to CDC6 of Saccharomyces cerevisiae.

1996 • 26 citations

Early events in eukaryotic DNA replication

1992 • 26 citations

The initiation of DNA replication in the budding yeast cell division cycle

1995 • 21 citations

The role of MCM/P1 proteins in the licensing of DNA replication

1996 • 18 citations

Initiation of Eukaryotic DNA-Replication

1994 • 3 citations

Protein:DNA interactions at yeast replication origins in vivo.

1995 • 2 citations