Protection of innate immunity by C5aR antagonist in septic mice

Sepsis and septic shock—A review of laboratory models and a proposal

1980 • 1,441 citations

The chemotactic receptor for human C5a anaphylatoxin

1991 • 660 citations

ANIMAL MODELS OF SEPSIS AND SHOCK

1998 • 577 citations

Demonstration of specific C5a receptor on intact human polymorphonuclear leukocytes.

1978 • 512 citations

Protective effects of C5a blockade in sepsis

1999 • 403 citations

The Neutrophil: Function and Regulation in Innate and Humoral Immunity

2001 • 304 citations

Role of Resident Peritoneal Macrophages and Mast Cells in Chemokine Production and Neutrophil Migration in Acute Inflammation: Evidence for an Inhibitory Loop Involving Endogenous IL-10

1999 • 300 citations

Update on the Mechanisms of Immune Suppression of Injury and Immune Modulation

1996 • 297 citations

Impaired mast cell-dependent natural immunity in complement C3-deficient mice

1997 • 283 citations

Low-Molecular-Weight Peptidic and Cyclic Antagonists of the Receptor for the Complement Factor C5a

1999 • 245 citations

Role of C5a in Multiorgan Failure During Sepsis

2001 • 216 citations

Expression of the Complement Anaphylatoxin C3a and C5a Receptors on Bronchial Epithelial and Smooth Muscle Cells in Models of Sepsis and Asthma

2001 • 205 citations

Requirement and role of C5a in acute lung inflammatory injury in rats.

1996 • 196 citations

Impaired Inflammatory Responses in the Reverse Arthus Reaction Through Genetic Deletion of the C5a Receptor

1997 • 191 citations

Cutting Edge: Targeted Disruption of the C3a Receptor Gene Demonstrates a Novel Protective Anti-Inflammatory Role for C3a in Endotoxin-Shock

2000 • 187 citations

Differential expression of complement receptors on human basophils and mast cells. Evidence for mast cell heterogeneity and CD88/C5aR expression on skin mast cells.

1995 • 182 citations

Complement factors and their receptors

1997 • 160 citations

Development of C5a receptor antagonists. Differential loss of functional responses.

1994 • 152 citations

Innate immunity and autoimmunity: from self-protection to self-destruction

2001 • 149 citations

Selection of a C5a Receptor Antagonist from Phage Libraries Attenuating the Inflammatory Response in Immune Complex Disease and Ischemia/Reperfusion Injury

1999 • 144 citations

Protective effects of anti‐C5a peptide antibodies in experimental sepsis

2001 • 135 citations

Neutrophil dysfunction in sepsis. II. Evidence for the role of complement activation products in cellular deactivation.

1981 • 129 citations

Circulating complement proteins in multiple trauma patients-Correlation with injury severity, development of sepsis, and outcome

1997 • 129 citations

POSTINJURY NEUTROPHIL PRIMING AND ACTIVATION STATES

1995 • 115 citations

Pathophysiologic basis of sepsis: Considerations for future strategies of intervention

2000 • 108 citations

A New Small Molecule C5a Receptor Antagonist Inhibits the Reverse-Passive Arthus Reaction and Endotoxic Shock in Rats

2000 • 107 citations

Pivotal Role of Signal Transducer and Activator of Transcription (Stat)4 and Stat6 in the Innate Immune Response during Sepsis

2001 • 106 citations

A Role for CD21/CD35 and CD19 in Responses to Acute Septic Peritonitis: A Potential Mechanism for Mast Cell Activation

2000 • 95 citations

Expression of the anaphylatoxin C5a receptor in non-myeloid cells

1999 • 94 citations

Small Molecular Probes for G-Protein-Coupled C5a Receptors: Conformationally Constrained Antagonists Derived from the C Terminus of the Human Plasma Protein C5a

1998 • 84 citations

Structural diversity in the extracellular faces of peptidergic G-protein-coupled receptors. Molecular cloning of the mouse C5a anaphylatoxin receptor.

1992 • 75 citations

Expression of C5a receptor in mouse brain: role in signal transduction and neurodegeneration

1999 • 74 citations

S19 ribosomal protein cross-linked dimer causes monocyte-predominant infiltration by means of molecular mimicry to complement C5a.

1998 • 72 citations

Effects of a new C5a receptor antagonist on C5a‐ and endotoxin‐ induced neutropenia in the rat

1999 • 70 citations

Complement component C5 modulates the systemic tumor necrosis factor response in murine endotoxic shock

1993 • 63 citations

Novel C5a Receptor Antagonists Regulate Neutrophil Functions In Vitro and In Vivo

1998 • 61 citations

Immunologic assessment of host defense impairment in patients with septic multiple organ failure: relationship between complement activation and changes in neutrophil function.

1994 • 56 citations

Recombinant human complement C5a receptor antagonist reduces infarct size after surgical revascularization

2000 • 49 citations

The pulmonary response of C5 sufficient and deficient mice to immune complexes.

1981 • 46 citations

Development of C5a receptor antagonists.

1999 • 39 citations

Rous-Whipple Award Lecture. Role of complement in lung inflammatory injury.

1996 • 37 citations

Response‐selective C5a agonists: differential effects on neutropenia and hypotension in the rat

1999 • 36 citations

Chemokine Regulation of Neutrophil Function in Surgical Inflammation

1999 • 34 citations

Synthetic C5a receptor agonists

1993 • 30 citations

[10] Iodination of chemokines for use in receptor binding analysis

1997 • 29 citations

Quantitative analysis of polymorphonuclear leukocyte superoxide anion generation in critically ill children

1985 • 23 citations

Two chemotactic factors, C5a and MIP-1α, dramatically alter the mortality from zymosan-induced multiple organ dysfunction syndrome (MODS): C5a contributes to MODS while MIP-1α has a protective role

1996 • 22 citations

C5a receptor antagonists.

1999 • 21 citations

Effects of Short Heat Exposure on Human Red and White Blood Cells

1998 • 19 citations

CSa Receptor Antagonists

1999 • 16 citations

Effects of L-156,602, a C5a Receptor Antagonist, on Mouse Experimental Models of Inflammation

1992 • 13 citations

IMPAIRED BACTERIAL CLEARANCE AFTER ACTIVATION OF THE COMPLEMENT AND COAGULATION SYSTEMS

1997 • 13 citations

A simple general method for (radio)iodination of a phenylalanine residue in peptides: preparation of [cyclic][D-Pen2,4'-125I-Phe4,D-Pen5]enkephalin, a peptide with extraordinary selectivity for .delta.-opioid receptors

1991 • 12 citations

Antagonistic peptides against human anaphylatoxin C5a.

1995 • 12 citations

Complement activation and neutrophil dysfunction in burned patients with sepsis —A study of two cases—

1989 • 4 citations