Innate immunity and autoimmunity: from self-protection to self-destruction

NATURAL KILLER CELLS IN ANTIVIRAL DEFENSE: Function and Regulation by Innate Cytokines

1999 • 2,128 citations

The Instructive Role of Innate Immunity in the Acquired Immune Response

1996 • 1,731 citations

Cytokines Induce the Development of Functionally Heterogeneous T Helper Cell Subsets

1998 • 1,569 citations

Dendritic cells directly trigger NK cell functions: Cross-talk relevant in innate anti-tumor immune responses in vivo

1999 • 1,066 citations

Defective NK Cell Activity and Th1 Response in IL-18–Deficient Mice

1998 • 914 citations

Cutting Edge: Cross-Talk Between Cells of the Innate Immune System: NKT Cells Rapidly Activate NK Cells

1999 • 856 citations

Induction of TH1 and TH2 responses: a key role for the ‘natural’ immune response?

1992 • 794 citations

Differential production of interferon-γ and interleukin-4 in response to Th1- and Th2-stimulating pathogens by γδ T cells in vivo

1995 • 672 citations

Diabetes induced by Coxsackie virus: Initiation by bystander damage and not molecular mimicry

1998 • 669 citations

Natural Killer T Cell Activation Inhibits Hepatitis B Virus Replication in Vivo

2000 • 589 citations

Critical contribution of liver natural killer T cells to a murine model of hepatitis

2000 • 532 citations

Regulation of IgE Responses to Inhaled Antigen in Mice by Antigen-Specific γδ T Cells

1994 • 406 citations

Overexpression of Natural Killer T Cells Protects Vα14-Jα281 Transgenic Nonobese Diabetic Mice against Diabetes

1998 • 390 citations

Human γδ T Cells Recognize Alkylamines Derived from Microbes, Edible Plants, and Tea

1999 • 368 citations

Regulation of Experimental Autoimmune Encephalomyelitis by Natural Killer (NK) Cells

1997 • 360 citations

Cd1-Reactive Natural Killer T Cells Are Required for Development of Systemic Tolerance through an Immune-Privileged Site

1999 • 360 citations

Interferon gamma production by natural killer (NK) cells and NK1.1+ T cells upon NKR-P1 cross-linking.

1996 • 349 citations

Selective induction of NK cell proliferation and cytotoxicity by activated NKT cells

2000 • 330 citations

Aerosol Insulin Induces Regulatory CD8 γδ T Cells That Prevent Murine Insulin-dependent Diabetes

1996 • 315 citations

Differential Expression of NK T Cell Vα24JαQ Invariant TCR Chain in the Lesions of Multiple Sclerosis and Chronic Inflammatory Demyelinating Polyneuropathy

2000 • 256 citations

Natural Killer Cells Determine Development of Allergen-induced Eosinophilic Airway Inflammation in Mice

1999 • 248 citations

Triggering of Natural Killer Cells by the Costimulatory Molecule CD80 (B7-1)

1996 • 233 citations

The interface between innate and acquired immunity: glycolipid antigen presentation by CD1d-expressing dendritic cells to NKT cells induces the differentiation of antigen-specific cytotoxic T lymphocytes

2000 • 222 citations

Natural killer cells determine the outcome of B cell–mediated autoimmunity

2000 • 187 citations

IL-18 Directs Autoreactive T Cells and Promotes Autodestruction in the Central Nervous System Via Induction of IFN-γ by NK Cells

2000 • 173 citations

Pancreatic expression of interferon-γ protects mice from lethal coxsackievirus B3 infection and subsequent myocarditis

2000 • 164 citations

A Role for NK Cells as Regulators of CD4+ T Cells in a Transfer Model of Colitis

1998 • 162 citations

Role of natural killer cells and TCRγ δ T cells in acute autoimmune encephalomyelitis

1998 • 159 citations

The role of transforming growth factor beta in the generation of suppression: an interaction between CD8+ T and NK cells.

1994 • 147 citations

A Defect in Interleukin 12–Induced Activation and Interferon γ Secretion of Peripheral Natural Killer T Cells in Nonobese Diabetic Mice Suggests New Pathogenic Mechanisms for Insulin-Dependent Diabetes Mellitus

1999 • 136 citations

CD1-restricted T-cell responses and microbial infection

2000 • 128 citations

Role of gamma delta T cells in murine collagen-induced arthritis.

1993 • 126 citations

A pathogenic role for gamma delta T cells in relapsing-remitting experimental allergic encephalomyelitis in the SJL mouse.

1996 • 123 citations

Lipid antigen presentation in the immune system; lessons learned from CD 1 d knockout mice

1999 • 121 citations

Downmodulation of the Inflammatory Response to Bacterial Infection by γδ T Cells Cytotoxic for Activated Macrophages

2000 • 118 citations

Viruses, host responses, and autoimmunity

1999 • 117 citations

Polymorphisms in IL-1β and IL-1 receptor antagonist genes are associated with myasthenia gravis

1998 • 84 citations

Immunopathology or Organ‐Specific Autoimmunity as a Consequence of Virus Infection

1996 • 68 citations

A comparison of efficacy and specificity of three NK depleting antibodies

1996 • 66 citations

Interactions between B lymphocytes and NK cells

1994 • 65 citations

Inhibitory MHC class I receptors on γδ T cells in tumour immunity and autoimmunity

2000 • 58 citations

Persisting viruses and chronic inflammation: understanding their relation to autoimmunity

1998 • 58 citations

Endogenous Testosterone Concentrations in Rat Testis Interstitial Tissue and Seminiferous Tubules during in vitro Incubation

1972 • 54 citations

Natural killer cell number and activity in multiple sclerosis

1989 • 50 citations

Retroviruses and Systemic Lupus Erythematosus

1996 • 44 citations

Anti-asialo GM1 antibody suppression of cyclophosphamide-induced diabetes in NOD mice.

1991 • 37 citations

Elevated frequencies of natural killer T lymphocytes in myasthenia gravis

1999 • 20 citations

Phenotypic and functional properties of γδ T Cells from patients with Guillain Barré syndrome

2000 • 17 citations

A protective role of gamma delta T cells in primary infection with Listeria monocytogenes in autoimmune non-obese diabetic mice.

1995 • 11 citations