Expression of the Complement Anaphylatoxin C3a and C5a Receptors on Bronchial Epithelial and Smooth Muscle Cells in Models of Sepsis and Asthma

Inflammation. Basic principles and clinical correlates

1989 • 2,424 citations

Interleukin 5 deficiency abolishes eosinophilia, airways hyperreactivity, and lung damage in a mouse asthma model.

1996 • 1,382 citations

MOLECULAR ORGANIZATION AND FUNCTION OF THE COMPLEMENT SYSTEM

1988 • 831 citations

The chemotactic receptor for human C5a anaphylatoxin

1991 • 660 citations

Differentiated structure and function of cultures from human tracheal epithelium

1992 • 365 citations

A role for the C3a anaphylatoxin receptor in the effector phase of asthma

2000 • 356 citations

The C5a chemoattractant receptor mediates mucosal defence to infection

1996 • 345 citations

C3a and C5a Stimulate Chemotaxis of Human Mast Cells

1997 • 326 citations

Pulmonary alveolar type II epithelial cells synthesize and secrete proteins of the classical and alternative complement pathways.

1988 • 281 citations

C3a is a chemotaxin for human eosinophils but not for neutrophils. I. C3a stimulation of neutrophils is secondary to eosinophil activation.

1995 • 272 citations

Effects of anti-C5a antibodies on the adult respiratory distress syndrome in septic primates.

1986 • 267 citations

Molecular Cloning and Characterization of the Human Anaphylatoxin C3a Receptor

1996 • 264 citations

C3a and C5a are chemotaxins for human mast cells and act through distinct receptors via a pertussis toxin-sensitive signal transduction pathway.

1996 • 250 citations

Cellular expression of the C5a anaphylatoxin receptor (C5aR): demonstration of C5aR on nonmyeloid cells of the liver and lung.

1995 • 250 citations

Expression of the receptor for complement C5a (CD88) is up-regulated on reactive astrocytes, microglia, and endothelial cells in the inflamed human central nervous system.

1997 • 237 citations

Complement Peptides C3a- and C5a-Induced Mediator Release from Dissociated Human Skin Mast Cells

1994 • 221 citations

Expression of the receptors for the C5a anaphylatoxin, interleukin-8 and FMLP by human astrocytes and microglia

1995 • 207 citations

Human T Cells Express the C5a Receptor and Are Chemoattracted to C5a

1999 • 203 citations

The Receptor for Complement Anaphylatoxin C3a Is Expressed by Myeloid Cells and Nonmyeloid Cells in Inflamed Human Central Nervous System: Analysis in Multiple Sclerosis and Bacterial Meningitis

1998 • 203 citations

Requirement and role of C5a in acute lung inflammatory injury in rats.

1996 • 196 citations

Cutting Edge: Targeted Disruption of the C3a Receptor Gene Demonstrates a Novel Protective Anti-Inflammatory Role for C3a in Endotoxin-Shock

2000 • 187 citations

Differential expression of complement receptors on human basophils and mast cells. Evidence for mast cell heterogeneity and CD88/C5aR expression on skin mast cells.

1995 • 182 citations

Expression cloning of the human C3a anaphylatoxin receptor (C3aR) from differentiated U‐937 cells

1996 • 180 citations

Biologically active products of complement and acute lung injury in patients with the sepsis syndrome.

1984 • 175 citations

C3a activates reactive oxygen radical species production and intracellular calcium transients in human eosinophils

1994 • 168 citations

Characterization of a Receptor for C5a Anaphylatoxin on Human Eosinophils

1989 • 165 citations

The Human C3a Receptor Is Expressed on Neutrophils and Monocytes, but Not on B or T Lymphocytes

1997 • 164 citations

Identification and characterization of the complement C5a anaphylatoxin receptor on human astrocytes.

1995 • 163 citations

A Comparison of C3a and C5a-Mediated Stable Adhesion of Rolling Eosinophils in Postcapillary Venules and Transendothelial Migration In Vitro and In Vivo

1999 • 158 citations

C3a activates the respiratory burst in human polymorphonuclear neutrophilic leukocytes via pertussis toxin-sensitive G-proteins

1994 • 154 citations

Receptor for the C3a anaphylatoxin is expressed by neurons and glial cells

1999 • 153 citations

Activation of human neutrophils by C3a and C5A Comparison of the effects on shape changes, chemotaxis, secretion, and respiratory burst

1994 • 150 citations

Regulation of B cell functions by C3a and C3a(desArg): suppression of TNF-alpha, IL-6, and the polyclonal immune response.

1997 • 126 citations

Adenovirus-mediated gene transfer to ciliated airway epithelia requires prolonged incubation time

1996 • 125 citations

Mechanisms of Enhanced Lung Injury during Sepsis

1999 • 123 citations

Anaphylatoxins: Possible Roles in Disease

1986 • 121 citations

Regulation of IL-6 Synthesis in Human Peripheral Blood Mononuclear Cells by C3a and C3adesArg

1999 • 118 citations

Pulmonary injury induced by C3a and C5a anaphylatoxins.

1980 • 116 citations

A mechanism of action for anaphylatoxin C3a stimulation of mast cells.

1992 • 100 citations

The C5a receptor is expressed in normal renal proximal tubular but not in normal pulmonary or hepatic epithelial cells

2000 • 99 citations

Evaluation of C3a receptor expression on human leucocytes by the use of novel monoclonal antibodies

1999 • 95 citations

C3a and C5a enhance granulocyte adhesion to endothelial and epithelial cell monolayers: epithelial and endothelial priming is required for C3a-induced eosinophil adhesion

2000 • 87 citations

Potentiation of the anaphylatoxins in vivo using an inhibitor of serum carboxypeptidase N (SCPN). I. Lethality and pathologic effects on pulmonary tissue.

1983 • 85 citations

Degranulation from Human Eosinophils Stimulated with C3a and C5a

1994 • 83 citations

A neuronal C5a receptor and an associated apoptotic signal transduction pathway

1998 • 83 citations

Human chemotaxis receptor genes cluster at 19q13.3-13.4. Characterization of the human C5a receptor gene

1993 • 81 citations

Chemotaxis by mouse macrophage cell lines.

1981 • 79 citations

Expression of high‐ and low‐affinity receptors for C3a on the human mast cell line, HMC‐1

1996 • 77 citations

Structural diversity in the extracellular faces of peptidergic G-protein-coupled receptors. Molecular cloning of the mouse C5a anaphylatoxin receptor.

1992 • 75 citations

Demonstration of a specific C3a receptor on guinea pig platelets.

1988 • 73 citations

Chronic myelogenous leukemia‐derived basophilic granulocytes express a functional active receptor for the anaphylatoxin C3a

1993 • 69 citations

Histamine-Induced Inhibition of Normal Human Basophil Chemotaxis to C5a

1977 • 66 citations

LUNG INFLAMMATION: Normal Host Defense or a Complication of Some Diseases?

1987 • 64 citations

Generation of anaphylatoxin C3a in plasma and bronchoalveolar lavage fluid in trauma patients at risk for the adult respiratory distress syndrome

1992 • 61 citations

The mouse anaphylatoxin C3a receptor: molecular cloning, genomic organization, and functional expression.

1997 • 60 citations

Identification of neutrophil chemotactie factors in bronchoalveolar lavage fluid of asthmatic patients

1997 • 57 citations

ELISA of complement C3a in bronchoalveolar lavage fluid

1992 • 47 citations

C5a Receptor and Interleukin-6 Are Expressed in Tissue Macrophages and Stimulated Keratinocytes but not in Pulmonary and Intestinal Epithelial Cells

1999 • 46 citations

Characterization of C3a anaphylatoxin receptor on guinea-pig macrophages.

1993 • 42 citations

Cultured human glomerular mesangial cells express the C5a receptor

1998 • 42 citations

Cloning and Characterization of Rat C3a Receptor: Differential Expression of Rat C3a and C5a Receptors by LPS Stimulation

1998 • 40 citations

Complement Anaphylatoxins (C3a, C4a, C5a) and Their Receptors (C3aR, C5aR/CD88) as Therapeutic Targets in Inflammation

2000 • 40 citations

Cloning and functional characterization of the mouse C3a anaphylatoxin receptor gene

1997 • 39 citations

Analysis of the Interaction of Human C5a and C5a des Arg with Human Monocytes and Neutrophils: Flow Cytometric and Chemotaxis Studies

1989 • 36 citations

The degradation product of the C5a anaphylatoxin C5a_desarg retains basophil‐activating properties

1994 • 35 citations

Complement activation and increased alveolar-capillary permeability after major surgery and in adult respiratory distress syndrome

1987 • 34 citations

Differential expression of the C5a receptor on the main cell types of rat liver as demonstrated with a novel monoclonal antibody and by C5a anaphylatoxin-induced Ca2+ release.

1999 • 34 citations

C3a activates the respiratory burst in human polymorphonuclear neutrophilic leukocytes via pertussis toxin-sensitive G-proteins

1994 • 29 citations

Complement Anaphylatoxins (C3a, C4a, C5a) and Their Receptors (C3aR, C5aR/CD88) as Therapeutic Targets in Inflammation

2003 • 27 citations

cDNA Cloning and Characterization of Rat C5a Anaphylatoxin Receptor

1997 • 26 citations

Minor role of the C3a receptor in systemic anaphylaxis in the guinea pig

2000 • 23 citations

Modulation of Phenotypic and Functional Properties of Normal Human Mononuclear Phagocytes by Granulocyte-Macrophage Colony-Stimulating Factor

1994 • 22 citations

Synergism between Inflammatory MediatorsIn Vivo: Induction of Airway Hyperresponsiveness to C3a in the Guinea Pig

1988 • 18 citations

Immunopharmacology of Anaphylatoxin-Induced Bronchoconstrictor Responses

1986 • 18 citations

Identification of neutrophil chemotactic factors in bronchoalveolar lavage fluid of asthmatic patients

1997 • 17 citations

Molecular Cloning of Two Isoforms of the Guinea Pig C3a Anaphylatoxin Receptor: Alternative Splicing in the Large Extracellular Loop

1998 • 16 citations

Contraction of guinea pig lung by synthetic oligopeptides related to human C3a

1984 • 16 citations

Recombinant human C5a-induced bronchoconstriction in the guinea-pig: A histamine independent mechanism

1990 • 11 citations

Prolonged elevation of intracellular cyclic AMP levels in U937 cells increases the number of receptors for and the responses to formylmethionyl-leucylphenylalanine, independently of the differentiation process

1995 • 11 citations

Evaluation of C3A receptor expression on human leukocytes by the use of novel monoclonal antibodies

1998 • 9 citations

Tissue expression pattern of the mouse GPI-DAF and its potential role in a murine model of autoimmune disease

2000 • 1 citations

A C3a-receptor defective guinea pig strain exhibits decreased bronchial reactivity in an ovalbumin-induced asthma model

2000 • 1 citations