The Neutrophil: Function and Regulation in Innate and Humoral Immunity

Rho GTPases and the Actin Cytoskeleton

1998 • 6,129 citations

Chronic Granulomatous Disease: Report on a National Registry of 368 Patients

2000 • 1,680 citations

Granules of the Human Neutrophilic Polymorphonuclear Leukocyte

1997 • 1,444 citations

Inside the Neutrophil Phagosome: Oxidants, Myeloperoxidase, and Bacterial Killing

1998 • 1,443 citations

Inside the Neutrophil Phagosome: Oxidants, Myeloperoxidase, and Bacterial Killing

1998 • 1,249 citations

Central Role for G Protein-Coupled Phosphoinositide 3-Kinase γ in Inflammation

2000 • 1,209 citations

PECAM-1 is required for transendothelial migration of leukocytes.

1993 • 1,134 citations

Function of PI3Kγ in Thymocyte Development, T Cell Activation, and Neutrophil Migration

2000 • 1,031 citations

Identification of Two Distinct Mechanisms of Phagocytosis Controlled by Different Rho GTPases

1998 • 993 citations

Crystal structure of the A domain from the a subunit of integrin CR3 (CD11 b/CD18)

1995 • 893 citations

Genetic, Biochemical, and Clinical Features of Chronic Granulomatous Disease

2000 • 869 citations

Roles of PLC-β2 and -β3 and PI3Kγ in Chemoattractant-Mediated Signal Transduction

2000 • 825 citations

A Controlled Trial of Interferon Gamma to Prevent Infection in Chronic Granulomatous Disease

1991 • 785 citations

A mechanism for the antiinflammatory effects of corticosteroids: the glucocorticoid receptor regulates leukocyte adhesion to endothelial cells and expression of endothelial-leukocyte adhesion molecule 1 and intercellular adhesion molecule 1.

1992 • 727 citations

Mice lacking neutrophil elastase reveal impaired host defense against gram negative bacterial sepsis

1998 • 686 citations

Neutrophil gelatinase B potentiates interleukin-8 tenfold by aminoterminal processing, whereas it degrades CTAP-III, PF-4, and GRO-α and leaves RANTES and MCP-2 intact

2000 • 653 citations

Leukocyte Trafficking Mediated by Selectin-Carbohydrate Interactions

1995 • 648 citations

A Novel Role for the β2 Integrin CD11b/CD18 in Neutrophil Apoptosis: A Homeostatic Mechanism in Inflammation

1996 • 645 citations

Perspectives series: cell adhesion in vascular biology. Role of PSGL-1 binding to selectins in leukocyte recruitment.

1997 • 620 citations

Identification of the homologous beige and Chediak–Higashi syndrome genes

1996 • 536 citations

Identification and mutation analysis of the complete gene for Chediak–Higashi syndrome

1996 • 536 citations

Chemoattractant signaling and leukocyte activation

1995 • 510 citations

Role of Rho in Chemoattractant-Activated Leukocyte Adhesion Through Integrins

1996 • 494 citations

Role of PSGL-1 binding to selectins in leukocyte recruitment.

1997 • 491 citations

Neutrophil rolling, arrest, and transmigration across activated, surface-adherent platelets via sequential action of P-selectin and the beta 2-integrin CD11b/CD18

1996 • 484 citations

Human neutrophil immunodeficiency syndrome is associated with an inhibitory Rac2 mutation

2000 • 476 citations

Oxidative Autoactivation of Latent Collagenase by Human Neutrophils

1985 • 466 citations

Purified cytochrome b from human granulocyte plasma membrane is comprised of two polypeptides with relative molecular weights of 91,000 and 22,000.

1987 • 459 citations

The dynamic regulation of integrin adhesiveness

1994 • 456 citations

Two cytosolic components of the human neutrophil respiratory burst oxidase translocate to the plasma membrane during cell activation.

1990 • 435 citations

Mutations in the X-linked and autosomal recessive forms of chronic granulomatous disease

1996 • 424 citations

Regulation of Human Leukocyte p21-Activated Kinases Through G Protein—Coupled Receptors

1995 • 415 citations

Neutrophils Emigrate from Venules by a Transendothelial Cell Pathway in Response to FMLP

1998 • 415 citations

Recombinant bactericidal/permeability-increasing protein (rBPI21) as adjunctive treatment for children with severe meningococcal sepsis: a randomised trial

2000 • 405 citations

Relative Contribution of LFA-1 and Mac-1 to Neutrophil Adhesion and Migration

1999 • 403 citations

Neutrophil rolling, arrest, and transmigration across activated, surface-adherent platelets via sequential action of P-selectin and the beta 2-integrin CD11b/CD18

1996 • 400 citations

Long-Lived Oxidants Generated by Human Neutrophils: Characterization and Bioactivity

1983 • 396 citations

Immunodeficiency Diseases Caused by Defects in Phagocytes

2000 • 389 citations

Interaction of Rac with p67 ^phox and Regulation pf Phagocytic NADPH Oxidase Activity

1994 • 384 citations

Impaired granulopoiesis, myelodysplasia, and early lethality in CCAAT/enhancer binding protein ɛ-deficient mice

1997 • 379 citations

The Syk Protein Tyrosine Kinase Is Essential for Fcγ Receptor Signaling in Macrophages and Neutrophils

1998 • 378 citations

Rho, rac and cdc42 GTPases: regulators of actin structures, cell adhesion and motility

1995 • 374 citations

CD31/PECAM-1 is a ligand for alpha v beta 3 integrin involved in adhesion of leukocytes to endothelium.

1995 • 367 citations

Assembly of the neutrophil respiratory burst oxidase. Protein kinase C promotes cytoskeletal and membrane association of cytosolic oxidase components.

1991 • 346 citations

Colchicine alters the quantitative and qualitative display of selectins on endothelial cells and neutrophils.

1995 • 346 citations

Converting enzyme-independent release of tumor necrosis factor α and IL-1β from a stimulated human monocytic cell line in the presence of activated neutrophils or purified proteinase 3

1999 • 346 citations

Degradation of Outer Membrane Protein A in Escherichia coli Killing by Neutrophil Elastase

2000 • 345 citations

p38 mitogen-activated protein kinase activation is required for human neutrophil function triggered by TNF-alpha or FMLP stimulation.

1998 • 336 citations

Methotrexate inhibits neutrophil function by stimulating adenosine release from connective tissue cells.

1991 • 336 citations

Inflammatory roles of P-selectin.

1993 • 336 citations

Polymorphonuclear leukocyte adhesion triggers the disorganization of endothelial cell-to-cell adherens junctions.

1996 • 334 citations

CR3 (Mac-1, alpha M beta 2, CD11b/CD18) and Fc gamma RIII cooperate in generation of a neutrophil respiratory burst: requirement for Fc gamma RIII and tyrosine phosphorylation.

1994 • 332 citations

Immune interferon induces the receptor for monomeric IgG1 on human monocytic and myeloid cells.

1983 • 330 citations

Interleukin 8-stimulated phosphatidylinositol-3-kinase activity regulates the migration of human neutrophils independent of extracellular signal-regulated kinase and p38 mitogen-activated protein kinases

1997 • 314 citations

Mobilization of granules and secretory vesicles during in vivo exudation of human neutrophils.

1995 • 313 citations

LFA-1 is sufficient in mediating neutrophil emigration in Mac-1-deficient mice.

1997 • 291 citations

Tyrosine kinases and tyrosine-based activation motifs. Current research on activation via the T cell antigen receptor.

1992 • 287 citations

Neutrophil rolling altered by inhibition of L-selectin shedding in vitro

1996 • 285 citations

p38 Mitogen-Activated Protein Kinase Activation Is Required for Human Neutrophil Function Triggered by TNF-α or FMLP Stimulation

1998 • 269 citations

Activation of the endogenous metalloproteinase, gelatinase, by triggered human neutrophils.

1986 • 267 citations

Ins and outs of LFA-1

1995 • 260 citations

Myeloperoxidase Deficiency

1981 • 246 citations

Interleukin-8 Regulation of the Ras/Raf/Mitogen-activated Protein Kinase Pathway in Human Neutrophils

1996 • 245 citations

Defensins

1990 • 241 citations

Tetratricopeptide Repeat (TPR) Motifs of p67 Participate in Interaction with the Small GTPase Rac and Activation of the Phagocyte NADPH Oxidase

1999 • 230 citations

Leukocyte adhesion deficiency type 1 (LAD-1)/variant. A novel immunodeficiency syndrome characterized by dysfunctional beta2 integrins.

1997 • 224 citations

Transendothelial migration of neutrophils involves integrin-associated protein (CD47).

1995 • 217 citations

Antimicrobial peptides of phagocytes and epithelia

1997 • 209 citations

Regulation of the Neutrophil Respiratory Burst Oxidase

1998 • 209 citations

The potent anti-Staphylococcus aureus activity of a sterile rabbit inflammatory fluid is due to a 14-kD phospholipase A2.

1996 • 208 citations

Elevation of Intracellular cAMP Inhibits RhoA Activation and Integrin-dependent Leukocyte Adhesion Induced by Chemoattractants

1997 • 205 citations

Stimulation of human neutrophils with formyl-methionyl-leucyl-phenylalanine induces tyrosine phosphorylation and activation of two distinct mitogen-activated protein-kinases.

1993 • 201 citations

The third component of complement (C3) is responsible for the intracellular survival of Leishmania major

1987 • 198 citations

Gp91 ^phox is the heme binding subunit of the superoxide-generating NADPH oxidase

1998 • 198 citations

Bioactive Proteinase 3 on the Cell Surface of Human Neutrophils: Quantification, Catalytic Activity, and Susceptibility to Inhibition

2000 • 193 citations

Cocapping of the leukoadhesin molecules complement receptor type 3 and lymphocyte function-associated antigen-1 with Fc gamma receptor III on human neutrophils. Possible role of lectin-like interactions.

1993 • 192 citations

Signaling Functions of L-selectin

1995 • 190 citations

Sulfatides trigger increase of cytosolic free calcium and enhanced expression of tumor necrosis factor-alpha and interleukin-8 mRNA in human neutrophils. Evidence for a role of L-selectin as a signaling molecule.

1994 • 188 citations

Mechanism of inhibition of myeloperoxidase by anti-inflammatory drugs

1991 • 187 citations

Modes of action of aspirin-like drugs: Salicylates inhibit Erk activation and integrin-dependent neutrophil adhesion

1998 • 185 citations

The phosphorylation targets of p47phox, a subunit of the respiratory burst oxidase. Functions of the individual target serines as evaluated by site-directed mutagenesis.

1995 • 184 citations

Recombinant human interferon-gamma reconstitutes defective phagocyte function in patients with chronic granulomatous disease of childhood.

1988 • 179 citations

The bactericidal/permeability-increasing protein (BPI) in antibacterial host defense

1998 • 172 citations

A novel leukocyte adhesion deficiency caused by expressed but nonfunctional β2 integrins Mac-1 and LFA-1

1999 • 167 citations

Presence of Proteinase 3 in Secretory Vesicles: Evidence of a Novel, Highly Mobilizable Intracellular Pool Distinct From Azurophil Granules

1999 • 163 citations

Potentiation of the oxidative burst of human neutrophils. A signaling role for L-selectin

1994 • 163 citations

Up-regulation of the iC3b receptor (CR3) is neither necessary nor sufficient to promote neutrophil aggregation.

1988 • 161 citations

The cell surface glycoprotein Mac-1 (CD11b/CD18) mediates neutrophil adhesion and modulates degranulation independently of its quantitative cell surface expression.

1989 • 158 citations

Priming of the Neutrophil Respiratory Burst Involves p38 Mitogen-activated Protein Kinase-dependent Exocytosis of Flavocytochrome b 558-containing Granules

2000 • 157 citations

An opsonic function of the neutrophil bactericidal/permeability-increasing protein depends on both its N- and C-terminal domains

1997 • 157 citations

Targeting of proteins to granule subsets is determined by timing and not by sorting: The specific granule protein NGAL is localized to azurophil granules when expressed in HL-60 cells.

1996 • 157 citations

A role for the actin-bundling protein<scp>l</scp>-plastin in the regulation of leukocyte integrin function

1998 • 155 citations

Phosphorylation of the Respiratory Burst Oxidase Subunit p67 during Human Neutrophil Activation

1997 • 154 citations

Glucocorticoid Receptor Regulates Expression of L-Selectin and CD11/CD18 on Human Neutrophils

1997 • 151 citations

Mobilization of potent plasma bactericidal activity during systemic bacterial challenge. Role of group IIA phospholipase A2.

1998 • 149 citations

Integrin-mediated signaling in human neutrophil functioning

1999 • 149 citations

Extracellular Ca2+ modulates leukocyte function-associated antigen-1 cell surface distribution on T lymphocytes and consequently affects cell adhesion

1994 • 148 citations

Fc gamma receptor III induces actin polymerization in human neutrophils and primes phagocytosis mediated by Fc gamma receptor II.

1991 • 143 citations

Cholesterol Chlorohydrin Synthesis by the Myeloperoxidase-Hydrogen Peroxide-Chloride System: Potential Markers for Lipoproteins Oxidatively Damaged by Phagocytes

1994 • 142 citations

Chemoattractant-induced tyrosine phosphorylation and activation of microtubule-associated protein kinase in human neutrophils.

1992 • 141 citations

Arrangement of the respiratory burst oxidase in the plasma membrane of the neutrophil.

1981 • 133 citations

Structural determinants of the action against Escherichia coli of a human inflammatory fluid phospholipase A2 in concert with polymorphonuclear leukocytes

1994 • 129 citations

Fc gamma receptor IIIb enhances Fc gamma receptor IIa function in an oxidant-dependent and allele-sensitive manner.

1995 • 127 citations

Neutrophil adhesion in leukocyte adhesion deficiency syndrome type 2.

1995 • 125 citations

Interferon-γ in the Management of Infectious Diseases

1995 • 124 citations

Role of stress-activated mitogen-activated protein kinase (p38) in beta 2-integrin-dependent neutrophil adhesion and the adhesion-dependent oxidative burst.

1998 • 120 citations

Interferon-γ in the Management of Infectious Diseases

1995 • 114 citations

Leukocyte infection by the granulocytic ehrlichiosis agent is linked to expression of a selectin ligand

1999 • 105 citations

CCAAT/Enhancer Binding Protein ɛ Is Critical for Effective Neutrophil-Mediated Response to Inflammatory Challenge

1999 • 105 citations

Effects of gamma-interferon on human neutrophils: protection from deterioration on storage

1992 • 105 citations

Collagenolytic metalloenzymes of the human neutrophil

1986 • 102 citations

The I Domain of Integrin Leukocyte Function-associated Antigen-1 Is Involved in a Conformational Change Leading to High Affinity Binding to Ligand Intercellular Adhesion Molecule 1 (ICAM-1)

1998 • 101 citations

Role of Stress-Activated Mitogen-Activated Protein Kinase (p38) in β2-Integrin-Dependent Neutrophil Adhesion and the Adhesion-Dependent Oxidative Burst

1998 • 98 citations

Individual and synergistic effects of rabbit granulocyte proteins on Escherichia coli.

1994 • 89 citations

Substitutions and deletions in the cytoplasmic domain of the phagocytic receptor Fc gamma RIIA: effect on receptor tyrosine phosphorylation and phagocytosis [published erratum appears in Blood 1994 Nov 1;84(9):3252]

1994 • 88 citations

Inhibition of the myeloperoxidase-H2O2-Cl− system of neutrophils by indomethacin and other non-steroidal anti-inflammatory drugs

1991 • 81 citations

Kinase-dependent Activation of the Leukocyte NADPH Oxidase in a Cell-free System

1997 • 81 citations

Mitogen-activated Protein Kinase in Neutrophils and Enucleate Neutrophil Cytoplasts

1996 • 78 citations

Mechanisms by which clofazimine and dapsone inhibit the myeloperoxidase system

1991 • 76 citations

Anionic Amphiphile-independent Activation of the Phagocyte NADPH Oxidase in a Cell-free System by p47 and p67 , Both in C Terminally Truncated Forms

1998 • 72 citations

Phosphatidylinositol 3-Kinase Mediates Chemoattractant-Stimulated, CD11b/CD18-Dependent Cell-Cell Adhesion of Human Neutrophils: Evidence for an ERK-Independent Pathway

1998 • 70 citations

Integrin-dependent homotypic adhesion of neutrophils. Arachidonic acid activates Raf-1/Mek/Erk via a 5-lipoxygenase- dependent pathway.

1998 • 70 citations

Cyclic AMP-increasing Agents Interfere with Chemoattractant-induced Respiratory Burst in Neutrophils as a Result of the Inhibition of Phosphatidylinositol 3-Kinase Rather than Receptor-operated Ca2+ Influx

1995 • 69 citations

CR3 (alphaM beta2; CD11b/CD18) restores IgG-dependent phagocytosis in transfectants expressing a phagocytosis-defective Fc gammaRIIA (CD32) tail-minus mutant.

1996 • 63 citations

Low-molecular-weight GTP-binding proteins and leukocyte signal transduction

1995 • 61 citations

Determinants of activation by complement of group II phospholipase A2 acting against Escherichia coli

1996 • 52 citations

p15s (15-kD Antimicrobial Proteins) Are Stored in the Secondary Granules of Rabbit Granulocytes: Implications for Antibacterial Synergy With the Bactericidal/Permeability-Increasing Protein in Inflammatory Fluids

1997 • 45 citations

Translocation of p21rac2 from Cytosol to Plasma Membrane Is Neither Necessary nor Sufficient for Neutrophil NADPH Oxidase Activity

1995 • 41 citations

The Role of Myeloperoxidase in the Microbicidal Activity of Polymorphonuclear Leukocytes

2008 • 39 citations

The Fcγ Receptor–Mediated Respiratory Burst of Rolling Neutrophils to Cytokine-Activated, Immune Complex-Bearing Endothelial Cells Depends on L-Selectin But Not on E-Selectin

1998 • 23 citations

CCAAT/Enhancer Binding Protein ɛ Is Critical for Effective Neutrophil-Mediated Response to Inflammatory Challenge

1999 • 16 citations

Rapid and prominent up-regulation of high-affinity receptor for immunoglobulin G (Fc gamma RI) by cross-linking of beta 2 integrins on polymorphonuclear leukocytes.

2000 • 13 citations