Pathophysiologic basis of sepsis: Considerations for future strategies of intervention

A human homologue of the Drosophila Toll protein signals activation of adaptive immunity

1997 • 5,522 citations

The Dorsoventral Regulatory Gene Cassette spätzle/Toll/cactus Controls the Potent Antifungal Response in Drosophila Adults

1996 • 3,854 citations

HMG-1 as a Late Mediator of Endotoxin Lethality in Mice

1999 • 3,314 citations

A Short-Term Study of Chimeric Monoclonal Antibody cA2 to Tumor Necrosis Factor α for Crohn's Disease

1997 • 3,152 citations

Anti-cachectin/TNF monoclonal antibodies prevent septic shock during lethal bacteraemia

1987 • 2,492 citations

Phylogenetic Perspectives in Innate Immunity

1999 • 2,478 citations

Innate Immunity: The Virtues of a Nonclonal System of Recognition

1997 • 2,397 citations

The Instructive Role of Innate Immunity in the Acquired Immune Response

1996 • 1,731 citations

Peptidoglycan- and Lipoteichoic Acid-induced Cell Activation Is Mediated by Toll-like Receptor 2

1999 • 1,714 citations

Treating Patients with Severe Sepsis

1999 • 1,006 citations

Anti-inflammatory therapies to treat sepsis and septic shock

1997 • 656 citations

Randomised controlled trial of CDP571 antibody to tumour necrosis factor-α in Crohn's disease

1997 • 400 citations

CYTOKINES AND ANTICYTOKINES IN THE PATHOGENESIS OF SEPSIS

1999 • 331 citations

THE STRUCTURAL BASIS OF T CELL ACTIVATION BY SUPERANTIGENS

1999 • 320 citations

Nuclear factor k B: a pivotal role in the systemic inflammatory response syndrome and new target for therapy

1998 • 306 citations

Derangements of Coagulation and Fibrinolysis in Critically III Patients with Sepsis and Septic Shock

1998 • 300 citations

Proinflammatory cytokines (tumor necrosis factor and interleukin 1) stimulate release of high mobility group protein-1 by pituicytes

1999 • 294 citations

Why immunomodulatory therapies have not worked in sepsis

1999 • 256 citations

Inflammation, sepsis, and coagulation.

1999 • 248 citations

Macrophage migration inhibitory factor is a critical mediator of the activation of immune cells by exotoxins of Gram-positive bacteria

1998 • 237 citations

Macrophage Migration Inhibitory Factor (MIF): A Glucocorticoid Counter-Regulator within the Immune System

1997 • 219 citations

Prevention of Jarisch–Herxheimer Reactions by Treatment with Antibodies against Tumor Necrosis Factor α

1996 • 187 citations

Regulation of the immune response by macrophage migration inhibitory factor: biological and structural features

1998 • 174 citations

Controlling the complement system in inflammation

1997 • 163 citations

The Toll of Innate Immunity on Microbial Pathogens

1999 • 144 citations

THE EPIDEMIOLOGY OF BACTERIAL SEPSIS

1999 • 108 citations

Molecular basis of host—pathogen interaction in septic shock

1998 • 96 citations

NEUTROPHIL AND ENDOTHELIAL CELL INTERACTIONS IN SEPSIS

1999 • 93 citations

Digestion of Streptococcus pneumoniae Cell Walls with Its Major Peptidoglycan Hydrolase Releases Branched Stem Peptides Carrying Proinflammatory Activity

1999 • 78 citations

Molecular and structural requirements of a lipoteichoic acid from Enterococcus hirae ATCC 9790 for cytokine-inducing, antitumor, and antigenic activities

1995 • 68 citations

Molecular biology of septic shock.

1998 • 54 citations

Mechanisms and Consequences of Phagocyte Adhesion to Endothelium

1999 • 53 citations

STRUCTURE AND FUNCTION OF STREPTOCOCCAL AND STAPHYLOCOCCAL SUPERANTIGENS IN SEPTIC SHOCK

1999 • 49 citations

Superantigens in human disease.

1999 • 45 citations

Anticytokine Strategies for the Treatment of Septic Shock: Relevance of Animal Models

1996 • 23 citations

Thirty years of anti-mediator treatment in sepsis and septic shock - what have we learned?

1998 • 17 citations