Nucleophosmin-anaplastic lymphoma kinase (NPM-ALK), a novel Hsp90-client tyrosine kinase: down-regulation of NPM-ALK expression and tyrosine phosphorylation in ALK(+) CD30(+) lymphoma cells by the Hsp90 antagonist 17-allylamino,17-demethoxygeldanamycin.

Signal transduction by receptors with tyrosine kinase activity

1990 • 5,528 citations

Molecular chaperones in cellular protein folding

1996 • 3,540 citations

Fusion of a Kinase Gene, ALK , to a Nucleolar Protein Gene, NPM , in Non-Hodgkin's Lymphoma

1994 • 2,375 citations

The expression of the Hodgkin's disease associated antigen Ki-1 in reactive and neoplastic lymphoid tissue: evidence that Reed-Sternberg cells and histiocytic malignancies are derived from activated lymphoid cells

1985 • 1,817 citations

Inhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: essential role for stress proteins in oncogenic transformation.

1994 • 1,426 citations

Crystal Structure of an Hsp90–Geldanamycin Complex: Targeting of a Protein Chaperone by an Antitumor Agent

1997 • 1,345 citations

Role of the Heat Shock Response and Molecular Chaperones in Oncogenesis and Cell Death

2000 • 1,028 citations

Structural Basis for Inhibition of the Hsp90 Molecular Chaperone by the Antitumor Antibiotics Radicicol and Geldanamycin

1999 • 979 citations

The co-chaperone CHIP regulates protein triage decisions mediated by heat-shock proteins

2000 • 971 citations

Role of the Human Heat Shock Protein hsp70 in Protection against Stress-Induced Apoptosis

1997 • 961 citations

CD30+ anaplastic large cell lymphoma: a review of its histopathologic, genetic, and clinical features

2000 • 923 citations

The Hsc70 co-chaperone CHIP targets immature CFTR for proteasomal degradation

2000 • 828 citations

ATP binding and hydrolysis are essential to the function of the Hsp90 molecular chaperone invivo

1998 • 709 citations

Detection of Anaplastic Lymphoma Kinase (ALK) and Nucleolar Protein Nucleophosmin (NPM)-ALK Proteins in Normal and Neoplastic Cells With the Monoclonal Antibody ALK1

1997 • 569 citations

Hsp90: Chaperoning signal transduction

2001 • 569 citations

The Amino-terminal Domain of Heat Shock Protein 90 (hsp90) That Binds Geldanamycin Is an ATP/ADP Switch Domain That Regulates hsp90 Conformation

1997 • 554 citations

ALK, the chromosome 2 gene locus altered by the t(2;5) in non-Hodgkin's lymphoma, encodes a novel neural receptor tyrosine kinase that is highly related to leukocyte tyrosine kinase (LTK)

1997 • 516 citations

The Ubiquitin-related BAG-1 Provides a Link between the Molecular Chaperones Hsc70/Hsp70 and the Proteasome

2000 • 478 citations

The benzoquinone ansamycin 17-allylamino-17-demethoxygeldanamycin binds to HSP90 and shares important biologic activities with geldanamycin

1998 • 474 citations

Polyubiquitination and Proteasomal Degradation of the p185c-B-2 Receptor Protein-tyrosine Kinase Induced by Geldanamycin

1996 • 460 citations

Disruption of the Raf-1-Hsp90 Molecular Complex Results in Destabilization of Raf-1 and Loss of Raf-1-Ras Association

1995 • 454 citations

Getting Newly Synthesized Proteins into Shape

2000 • 426 citations

Role of the Nucleophosmin (NPM) Portion of the Non-Hodgkin’s Lymphoma-Associated NPM-Anaplastic Lymphoma Kinase Fusion Protein in Oncogenesis

1997 • 371 citations

Perturbation of Hsp90 interaction with nascent CFTR prevents its maturation and accelerates its degradation by the proteasome

1998 • 367 citations

Sensitivity of Mature ErbB2 to Geldanamycin Is Conferred by Its Kinase Domain and Is Mediated by the Chaperone Protein Hsp90

2001 • 354 citations

DT-Diaphorase Expression and Tumor Cell Sensitivity to 17-Allylamino,17-demethoxygeldanamycin, an Inhibitor of Heat Shock Protein 90

1999 • 352 citations

Nucleophosmin–anaplastic lymphoma kinase associated with anaplastic large-cell lymphoma activates the phosphatidylinositol 3-kinase/Akt antiapoptotic signaling pathway

2000 • 317 citations

Characterization of the transforming activity of p80, a hyperphosphorylated protein in a Ki-1 lymphoma cell line with chromosomal translocation t(2;5).

1996 • 297 citations

Geldanamycin as a Potential Anti-Cancer Agent: Its Molecular Target and Biochemical Activity

1999 • 297 citations

Nucleophosmin-Anaplastic Lymphoma Kinase of Large-Cell Anaplastic Lymphoma Is a Constitutively Active Tyrosine Kinase That Utilizes Phospholipase C-γ To Mediate Its Mitogenicity

1998 • 281 citations

ALK Expression Defines a Distinct Group of T/Null Lymphomas (“ALK Lymphomas”) with a Wide Morphological Spectrum

1998 • 278 citations

Retrovirus-Mediated Gene Transfer of NPM-ALK Causes Lymphoid Malignancy in Mice

1997 • 278 citations

Destabilization of Raf-1 by Geldanamycin Leads to Disruption of the Raf-1–MEK–Mitogen-Activated Protein Kinase Signalling Pathway

1996 • 274 citations

The Heat Shock Protein 90 Antagonist Geldanamycin Alters Chaperone Association with p210bcr-abl and v-src Proteins before Their Degradation by the Proteasome

2000 • 269 citations

Role of phosphatidylinositol 3-kinase-Akt pathway in nucleophosmin/anaplastic lymphoma kinase-mediated lymphomagenesis.

2001 • 262 citations

Geldanamycin and its analogue 17-allylamino-17-demethoxygeldanamycin lowers Bcr-Abl levels and induces apoptosis and differentiation of Bcr-Abl-positive human leukemic blasts.

2001 • 250 citations

The Importance of ATP Binding and Hydrolysis by Hsp90 in Formation and Function of Protein Heterocomplexes

1999 • 224 citations

A Ki-1 (CD30)-positive human cell line (Karpas 299) established from a high-grade non-Hodgkin's lymphoma, showing a 2;5 translocation and rearrangement of the T-cell receptor beta-chain gene

1988 • 214 citations

The Physical Association of Multiple Molecular Chaperone Proteins with Mutant p53 Is Altered by Geldanamycin, an hsp90-Binding Agent

1998 • 206 citations

The hsp90-binding Antibiotic Geldanamycin Decreases Raf Levels and Epidermal Growth Factor Signaling without Disrupting Formation of Signaling Complexes or Reducing the Specific Enzymatic Activity of Raf Kinase

1997 • 202 citations

Gene expression profiling of human colon cancer cells following inhibition of signal transduction by 17-allylamino-17-demethoxygeldanamycin, an inhibitor of the hsp90 molecular chaperone

2000 • 200 citations

Herbimycin A Induces the 20 S Proteasome- and Ubiquitin-dependent Degradation of Receptor Tyrosine Kinases

1995 • 194 citations

Geldanamycin-Induced Destabilization of Raf-1 Involves the Proteasome

1997 • 193 citations

Differential interactions of p23 and the TPR-containing proteins Hop, Cyp40, FKBP52 and FKBP51 with Hsp90 mutants

1998 • 190 citations

Geldanamycin selectively destabilizes and conformationally alters mutated p53.

1995 • 185 citations

Benzoquinonoid ansamycins possess selective tumoricidal activity unrelated to src kinase inhibition.

1992 • 177 citations

The geldanamycins are potent inhibitors of the hepatocyte growth factor/scatter factor-met-urokinase plasminogen activator-plasmin proteolytic network.

2000 • 167 citations

Analysis of the t(2;5)(p23;q35) translocation by reverse transcription- polymerase chain reaction in CD30+ anaplastic large-cell lymphomas, in other non-Hodgkin's lymphomas of T-cell phenotype, and in Hodgkin's disease

1995 • 144 citations

erbB-2 oncogene inhibition by geldanamycin derivatives: synthesis, mechanism of action, and structure-activity relationships

1995 • 138 citations

KF25706, a novel oxime derivative of radicicol, exhibits in vivo antitumor activity via selective depletion of Hsp90 binding signaling molecules.

1999 • 137 citations

Molecular chaperones and the art of recognizing a lost cause

2001 • 123 citations

Mechanism of reversion of Rous sarcoma virus transformation by herbimycin A: reduction of total phosphotyrosine levels due to reduced kinase activity and increased turnover of p60v-src1.

1989 • 122 citations

Alk⁺ CD30⁺ lymphomas: a distinct molecular genetic subtype of non‐hodgkin's lymphoma

2001 • 118 citations

Nucleolar localization of the nucleophosmin-anaplastic lymphoma kinase is not required for malignant transformation.

1998 • 104 citations

Involvement of Heat Shock Protein 90 in the Degradation of Mutant Insulin Receptors by the Proteasome

1998 • 92 citations

Stoichiometry, Abundance, and Functional Significance of the hsp90/hsp70-based Multiprotein Chaperone Machinery in Reticulocyte Lysate

2001 • 89 citations

Geldanamycin Induces ErbB-2 Degradation by Proteolytic Fragmentation

2000 • 76 citations

The activated anaplastic lymphoma kinase increases cellular proliferation and oncogene up‐regulation in rat la fibroblasts

1997 • 73 citations

Benzoquinoid ansamycins (herbimycin A and geldanamycin) interfere with the maturation of growth factor receptor tyrosine kinases.

1999 • 68 citations

The tyrosine kinase NPM-ALK, associated with anaplastic large cell lymphoma, binds the intracellular domain of the surface receptor CD30 but is not activated by CD30 stimulation

1999 • 38 citations

Hsp70 Family Molecular Chaperones and Mutant Insulin Receptor: Differential Binding Specificities of BiP and Hsp70/Hsc70 Determines Accumulation or Degradation of Insulin Receptor

1996 • 34 citations

Adenovirus-p53-mediated gene therapy of anaplastic large cell lymphoma with t(2;5) in a nude mouse model

2000 • 26 citations

The Hsp90 Chaperone Family

1999 • 25 citations

Molecular variant of the NPM‐ALK rearrangement of Ki‐l lymphoma involving a cryptic ALK splice site

1996 • 24 citations

The cytoplasmic truncated receptor tyrosine kinase ALK‐ homodimer immortalizes and cooperates with ras in cellular transformation

2001 • 19 citations

The role of hsp70 in protection and repair of luciferase activity in vivo; experimental data and mathematical modelling

1999 • 19 citations

Expression of the ALK protein by anaplastic large-cell lymphomas correlates with high proliferative activity

2000 • 12 citations