DT-Diaphorase Expression and Tumor Cell Sensitivity to 17-Allylamino,17-demethoxygeldanamycin, an Inhibitor of Heat Shock Protein 90

Inhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: essential role for stress proteins in oncogenic transformation.

1994 • 1,426 citations

Crystal Structure of an Hsp90–Geldanamycin Complex: Targeting of a Protein Chaperone by an Antitumor Agent

1997 • 1,345 citations

Anti-cancer Drug Design

2018 • 1,309 citations

Identification and Structural Characterization of the ATP/ADP-Binding Site in the Hsp90 Molecular Chaperone

1997 • 1,235 citations

Repression of Heat Shock Transcription Factor HSF1 Activation by HSP90 (HSP90 Complex) that Forms a Stress-Sensitive Complex with HSF1

1998 • 1,198 citations

Structural Basis for Inhibition of the Hsp90 Molecular Chaperone by the Antitumor Antibiotics Radicicol and Geldanamycin

1999 • 979 citations

Preclinical pharmacologic evaluation of geldanamycin as an antitumor agent

1995 • 496 citations

The benzoquinone ansamycin 17-allylamino-17-demethoxygeldanamycin binds to HSP90 and shares important biologic activities with geldanamycin

1998 • 474 citations

Antibiotic radicicol binds to the N-terminal domain of Hsp90 and shares important biologic activities with geldanamycin

1998 • 396 citations

NAD(P)H:quinone oxidoreductase gene expression in human colon carcinoma cells: characterization of a mutation which modulates DT-diaphorase activity and mitomycin sensitivity.

1992 • 313 citations

DT-diaphorase and cancer chemotherapy

1992 • 284 citations

Targeting of the protein chaperone, HSP90, by the transformation suppressing agent, radicicol

1998 • 272 citations

Cytosolic NAD(P)H:(Quinone‐acceptor)oxidoreductase in human normal and tumor tissue: Effects of cigarette smoking and alcohol

1990 • 261 citations

Development of a Bicistronic Vector Driven by the Human Polypeptide Chain Elongation Factor 1α Promoter for Creation of Stable Mammalian Cell Lines That Express Very High Levels of Recombinant Proteins

1998 • 255 citations

Reductase Enzyme Expression Across the National Cancer Institute Tumor Cell Line Panel: Correlation With Sensitivity to Mitomycin C and EO9

1996 • 232 citations

The Physical Association of Multiple Molecular Chaperone Proteins with Mutant p53 Is Altered by Geldanamycin, an hsp90-Binding Agent

1998 • 206 citations

In vitro circumvention of cisplatin resistance by the novel sterically hindered platinum complex AMD473

1998 • 194 citations

Ethnic variation in the prevalence of a common NAD(P)H quinone oxidoreductase polymorphism and its implications for anti-cancer chemotherapy

1997 • 193 citations

The NCI anti-cancer drug screen: a smart screen to identify effectors of novel targets.

1997 • 168 citations

erbB-2 oncogene inhibition by geldanamycin derivatives: synthesis, mechanism of action, and structure-activity relationships

1995 • 138 citations

Metabolism of 17-(allylamino)-17-demethoxygeldanamycin (NSC 330507) by murine and human hepatic preparations.

1998 • 132 citations

Enzyme-directed bioreductive drug development revisited: a commentary on recent progress and future prospects with emphasis on quinone anticancer agents and quinone metabolizing enzymes, particularly DT-diaphorase.

1994 • 127 citations

The Role of NAD(P)H: Quinone Reductase (EC 1.6.99.2, DT-Diaphorase) in the Reductive Bioactivation of the Novel Indoloquinone Antitumor Agent E09

1991 • 122 citations

Depletion of p185 erbB2 , Raf-1 and mutant p53 proteins by geldanamycin derivatives correlates with antiproliferative activity

1997 • 104 citations

DT-diaphorase and cytochrome B5 reductase in human lung and breast tumours

1997 • 103 citations

Radicicol Leads to Selective Depletion of Raf Kinase and Disrupts K-Ras-activated Aberrant Signaling Pathway

1998 • 94 citations

The sensitivity of human tumour cells to quinone bioreductive drugs: What role for DT-diaphorase?

1992 • 77 citations

Bioreductive drugs into the next millennium.

1998 • 74 citations

Role of NAD(P)H:Quinone oxidoreductase (DT-diaphorase) in cytotoxicity and induction of DNA damage by streptonigrin

1996 • 72 citations

Enzymology of bioreductive drug activation.

1996 • 59 citations

Geldanamycin Prevents Nuclear Translocation of Mutant p53

1997 • 52 citations

Reduced folate carrier gene (RFC1) expression and anti-folate resistance in transfected and non-selected cell lines

1997 • 40 citations

Lack of a role for MRP1 in platinum drug resistance in human ovarian cancer cell lines

1998 • 39 citations

Geldanamycin-induced cytotoxicity in human colon-cancer cell lines: evidence against the involvement of c-Src or DT-diaphorase

1998 • 28 citations

Effects of a new antioestrogen, idoxifene, on cisplatin- and doxorubicin-sensitive and -resistant human ovarian carcinoma cell lines

1994 • 27 citations

Cell-cycle arrests and p53 accumulation induced by geldanamycin in human ovarian tumour cells

1996 • 25 citations