ALK Expression Defines a Distinct Group of T/Null Lymphomas (“ALK Lymphomas”) with a Wide Morphological Spectrum

Immunoenzymatic labeling of monoclonal antibodies using immune complexes of alkaline phosphatase and monoclonal anti-alkaline phosphatase (APAAP complexes).

1984 • 3,268 citations

Proposed Revised Criteria for the Classification of Acute Myeloid Leukemia

1985 • 2,981 citations

Fusion of a Kinase Gene, ALK , to a Nucleolar Protein Gene, NPM , in Non-Hodgkin's Lymphoma

1994 • 2,375 citations

Production of high-titer helper-free retroviruses by transient transfection.

1993 • 2,280 citations

The expression of the Hodgkin's disease associated antigen Ki-1 in reactive and neoplastic lymphoid tissue: evidence that Reed-Sternberg cells and histiocytic malignancies are derived from activated lymphoid cells

1985 • 1,817 citations

The expression of the Hodgkin's disease associated antigen Ki-1 in reactive and neoplastic lymphoid tissue: evidence that Reed-Sternberg cells and histiocytic malignancies are derived from activated lymphoid cells

1985 • 712 citations

Molecular characterization of ALK, a receptor tyrosine kinase expressed specifically in the nervous system

1997 • 703 citations

Detection of Anaplastic Lymphoma Kinase (ALK) and Nucleolar Protein Nucleophosmin (NPM)-ALK Proteins in Normal and Neoplastic Cells With the Monoclonal Antibody ALK1

1997 • 569 citations

ALK-Positive Lymphoma: A Single Disease With a Broad Spectrum of Morphology

1998 • 525 citations

ALK, the chromosome 2 gene locus altered by the t(2;5) in non-Hodgkin's lymphoma, encodes a novel neural receptor tyrosine kinase that is highly related to leukocyte tyrosine kinase (LTK)

1997 • 516 citations

CD30 (Ki-1) molecule: a new cytokine receptor of the tumor necrosis factor receptor superfamily as a tool for diagnosis and immunotherapy

1995 • 446 citations

Anaplastic large cell lymphomas expressing the novel chimeric protein p80NPM/ALK: a distinct clinicopathologic entity

1995 • 390 citations

Role of the Nucleophosmin (NPM) Portion of the Non-Hodgkin’s Lymphoma-Associated NPM-Anaplastic Lymphoma Kinase Fusion Protein in Oncogenesis

1997 • 371 citations

CD30‐positive large cell lymphomas (‘Ki‐1 lymphoma’) are associated with a chromosomal translocation involving 5q35

1990 • 336 citations

A New Subtype of Large B-Cell Lymphoma Expressing the ALK Kinase and Lacking the 2; 5 Translocation

1997 • 334 citations

Characterization of the transforming activity of p80, a hyperphosphorylated protein in a Ki-1 lymphoma cell line with chromosomal translocation t(2;5).

1996 • 297 citations

Retrovirus-Mediated Gene Transfer of NPM-ALK Causes Lymphoid Malignancy in Mice

1997 • 278 citations

A Small-Cell-Predominant Variant of Primary Ki-1 (CD30)+ T-Cell Lymphoma

1993 • 254 citations

Antigen retrieval techniques in immunohistochemistry: comparison of different methods

1997 • 245 citations

High incidence of the t(2;5)(p23;q35) translocation in anaplastic large cell lymphoma and its lack of detection in Hodgkin's disease. Comparison of cytogenetic analysis, reverse transcriptase-polymerase chain reaction, and P-80 immunostaining

1996 • 244 citations

Analysis of the<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mrow><mml:msub><mml:mrow><mml:mi mathvariant="italic">T</mml:mi></mml:mrow><mml:mrow><mml:mn>1</mml:mn><mml:mi mathvariant="italic">u</mml:mi></mml:mrow></mml:msub></mml:mrow></mml:math>⊗<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mrow><mml:msub><mml:mrow><mml:mi mathvariant="italic">h</mml:mi></mml:mrow><mml:mrow><mml:mi mathvariant="italic">g</mml:mi></mml:mrow></…

1995 • 216 citations

A Ki-1 (CD30)-positive human cell line (Karpas 299) established from a high-grade non-Hodgkin's lymphoma, showing a 2;5 translocation and rearrangement of the T-cell receptor beta-chain gene

1988 • 214 citations

The t(2;5) chromosomal translocation is not a common feature of primary cutaneous CD30+ lymphoproliferative disorders: comparison with anaplastic large-cell lymphoma of nodal origin [see comments]

1996 • 214 citations

Anaplastic large cell Ki‐1 lymphoma. Delineation of two morphological types

1989 • 189 citations

Lymphohistiocytic T-cell lymphoma (anaplastic large cell lymphoma CD30+/Ki-1 + with a high content of reactive histiocytes)

1990 • 188 citations

Inhibition of endogenous tissue alkaline phosphatase with the use of alkaline phosphatase conjugates in immunohistochemistry.

1981 • 179 citations

Diagnosis of t(2;5)(p23;q35)-associated Ki-1 lymphoma with immunohistochemistry

1994 • 178 citations

Sarcomatoid Variant of Anaplastic Large-Cell Ki-1 Lymphoma

1990 • 169 citations

Anaplastic Large Cell Lymphoma: A Distinct Molecular Pathologic Entity

1997 • 160 citations

Molecular detection of the (2;5) translocation of non-Hodgkin's lymphoma by reverse transcriptase-polymerase chain reaction

1995 • 149 citations

The monoclonal antibody ALK1 identifies a distinct morphological subtype of anaplastic large cell lymphoma associated with 2p23/ALK rearrangements.

1997 • 145 citations

Analysis of the t(2;5)(p23;q35) translocation by reverse transcription- polymerase chain reaction in CD30+ anaplastic large-cell lymphomas, in other non-Hodgkin's lymphomas of T-cell phenotype, and in Hodgkin's disease

1995 • 144 citations

Neutrophil-Rich, Ki-1-Positive Anaplastic Large-Cell Malignant Lymphoma

1995 • 126 citations

Monoclonal antibodies PG-B6a and PG-B6p recognize, respectively, a highly conserved and a formol-resistant epitope on the human BCL-6 protein amino-terminal region.

1996 • 107 citations

Nucleolar localization of the nucleophosmin-anaplastic lymphoma kinase is not required for malignant transformation.

1998 • 104 citations

Anaplastic large-cell lymphoma: clinical and prognostic evaluation of 90 adult patients.

1996 • 104 citations

Primary Ki-1-positive anaplastic large-cell lymphoma: A distinct clinicopathologic entity

1994 • 95 citations

ALK gene products in anaplastic large cell lymphomas and Hodgkin's disease

1995 • 82 citations

Transcripts of the npm-alk fusion gene in anaplastic large cell lymphoma, Hodgkin's disease, and reactive lymphoid lesions

1995 • 82 citations

Amplification of genomic DNA demonstrates the presence of the t(2;5) (p23;q35) in anaplastic large cell lymphoma, but not in other non- Hodgkin's lymphomas, Hodgkin's disease, or lymphomatoid papulosis

1996 • 81 citations

Heterogeneous nuclear expression of the promyelocytic leukemia (PML) protein in normal and neoplastic human tissues.

1996 • 81 citations

Residual mass following chemotherapy of seminoma

1997 • 81 citations

Antigen Unmasking on Formalin-Fixed Paraffin-Embedded Tissues Using Microwaves

1995 • 76 citations

Occurrence of the t(2;5)(p23;q35) in non-Hodgkin's lymphoma

1996 • 75 citations

Frequent expression of the NPM-ALK chimeric fusion protein in anaplastic large-cell lymphoma, lympho-histiocytic type.

1997 • 72 citations

Anaplastic large cell lymphoma and its morphological variants.

1997 • 62 citations

Isolation and characterization of the human nucleophosmin/B23 (NPM) gene: identification of the YY1 binding site at the 5' enhancer region

1997 • 53 citations

The NPM/ALK gene fusion in the pathogenesis of anaplastic large cell lymphoma.

1997 • 51 citations

Low frequency association of the t(2;5)(p23;q35) chromosomal translocation with CD30+ lymphomas from American and Asian patients. A reverse transcriptase-polymerase chain reaction study.

1995 • 51 citations

Ki-1-Anaplastic Large Cell Lymphoma: Is it a Discrete Entity?

1993 • 48 citations

CD30⁺ anaplastic large‐cell lymphoma, null type, with signet‐ring appearance

1997 • 45 citations

Use of an anti-ALK antibody in the characterization of anaplastic large-cell lymphoma of childhood

1997 • 43 citations

Anaplastic large cell lymphomas expressing the novel chimeric protein p80NPM/ALK: a distinct clinicopathologic entity.

1997 • 27 citations

The pathogenesis of large cell transformation in cutaneous T‐cell lymphoma is not associated with t(2;5)(p23;q35) chromosomal translocation

1997 • 24 citations

ALK-POSITIVE LYMPHOMA

1999 • 13 citations

Lymphohistiocytic T-cell Lymphoma and Peripheral T-cell Lymphoma Associated with Haemophagocytic Syndrome: Two Recently Recognized Entities Which Mimic Malignant Histiocytosis

1992 • 8 citations

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