Permeation of hydrophilic solutes through mitochondrial outer membranes: review on mitochondrial porins

A simple method for displaying the hydropathic character of a protein

1982 • 22,471 citations

AN ELECTRON-TRANSPORT SYSTEM ASSOCIATED WITH THE OUTER MEMBRANE OF LIVER MITOCHONDRIA

1967 • 2,311 citations

Mechanisms by which mitochondria transport calcium

1990 • 1,630 citations

Crystal structures explain functional properties of two E. coli porins

1992 • 1,493 citations

ENZYMATIC PROPERTIES OF THE INNER AND OUTER MEMBRANES OF RAT LIVER MITOCHONDRIA

1968 • 1,398 citations

Reconstitution of Cell Membrane Structure in vitro and its Transformation into an Excitable System

1962 • 1,380 citations

Filtration, diffusion, and molecular sieving through porous cellulose membranes.

1954 • 1,078 citations

Molecular basis of bacterial outer membrane permeability.

1985 • 904 citations

Lipids of mitochondria

1985 • 842 citations

Mitochondrial protein import

1989 • 820 citations

THE CREATINE-CREATINE PHOSPHATE ENERGY SHUTTLE

1985 • 746 citations

Molecular Architecture and Electrostatic Properties of a Bacterial Porin

1991 • 700 citations

Cardiolipins and biomembrane function

1992 • 597 citations

Formation of large, ion-permeable membrane channels by the matrix protein (porin) of Escherichia coli

1978 • 515 citations

Reconstitution in planar lipid bilayers of a voltage-dependent anion-selective channel obtained from paramecium mitochondria

1976 • 501 citations

A candidate for the permeability pathway of the outer mitochondrial membrane

1979 • 459 citations

Chapter 26 Preparation and Characterization of Mitochondria and Submitochondrial Particles of Rat Liver and Liver-Derived Tissues

1978 • 451 citations

Physical Chemistry

1971 • 436 citations

Mitochondrial contact sites. Lipid composition and dynamics.

1990 • 426 citations

Lipidic intramembranous particles

1984 • 416 citations

How mitochondria import proteins

1984 • 405 citations

Eukaryotes with no mitochondria

1987 • 385 citations

The concept of cellular evolution

1977 • 369 citations

The giant channel of the inner mitochondrial membrane is inhibited by cyclosporin A

1991 • 368 citations

CHARACTERISTICS OF ISOLATED AND PURIFIED PREPARATIONS OF THE OUTER AND INNER MEMBRANES OF MITOCHONDRIA*

1966 • 366 citations

Models for the structure of outer-membrane proteins of Escherichia coli derived from raman spectroscopy and prediction methods

1986 • 365 citations

Improved methods to isolate and subfractionate rat liver mitochondria. Lipid composition of the inner and outer membrane

1990 • 348 citations

Electrical capacity of black lipid films and of lipid bilayers made from monolayers

1975 • 336 citations

The Origin of Eukaryote and Archaebacterial Cells

1987 • 326 citations

Porins and specific channels of bacterial outer membranes

1992 • 326 citations

Regulation Of Carbohydrate Metabolism

2018 • 316 citations

Functional significance of mitochondrial bound hexokinase in tumor cell metabolism. Evidence for preferential phosphorylation of glucose by intramitochondrially generated ATP.

1988 • 313 citations

Origin of the eukaryotic nucleus determined by rate-invariant analysis of rRNA sequences

1988 • 311 citations

Ionic selectivity of pores formed by the matrix protein (porin) of Escherichia coli

1979 • 293 citations

Polymer inaccessible volume changes during opening and closing of a voltage-dependent ionic channel

1986 • 289 citations

Protein import into yeast mitochondria is accelerated by the outer membrane protein MAS70.

1990 • 276 citations

Selectivity Changes in Site-Directed Mutants of the VDAC Ion Channel: Structural Implications

1990 • 269 citations

Permeation of hydrophilic molecules through the outer membrane of gram‐negativ bacteria

1988 • 267 citations

Structure and Function of Porins from Gram-Negative Bacteria

1988 • 265 citations

A yeast mitochondrial outer membrane protein essential for protein import and cell viability

1990 • 263 citations

Cytoplasmic type 80S ribosomes associated with yeast mitochondria. IV. Attachment of ribosomes to the outer membrane of isolated mitochondria.

1975 • 262 citations

The mitochondrial megachannel is the permeability transition pore

1992 • 262 citations

Evidence for identity between the hexokinase-binding protein and the mitochondrial porin in the outer membrane of rat liver mitochondria

1982 • 254 citations

Porin from Bacterial and Mitochondrial Outer Membrane

1985 • 246 citations

Respiratory Control and the Integration of Heart High-Energy Phosphate Metabolism by Mitochondrial Creatine Kinase

1985 • 241 citations

Cloning and functional expression in yeast of two human isoforms of the outer mitochondrial membrane channel, the voltage-dependent anion channel.

1993 • 239 citations

Swelling and contraction of the mitochondrial matrix. I. A structural interpretation of the relationship between light scattering and matrix volume.

1985 • 237 citations

Patch-clamping of the inner mitochondrial membrane reveals a voltage-dependent ion channel

1987 • 232 citations

Effect on solute size on diffusion rates through the transmembrane pores of the outer membrane of Escherichia coli.

1981 • 230 citations

Single voltage-dependent chloride-selective channels of large conductance in cultured rat muscle

1983 • 229 citations

The inner mitochondrial membrane contains ion‐conducting channels similar to those found in bacteria

1989 • 224 citations

The proton conducting F0-part of bacterial ATP synthases

1984 • 223 citations

The Nature of the Negative Resistance in Bimolecular Lipid Membranes Containing Excitability-Inducing Material

1970 • 222 citations

Pore protein and the hexokinase‐binding protein from the outer membrane of rat liver mitochondria are identical

1982 • 222 citations

Mitochondrial outer membrane contains a protein producing nonspecific diffusion channels.

1980 • 214 citations

Translocation arrest by reversible folding of a precursor protein imported into mitochondria. A means to quantitate translocation contact sites.

1989 • 212 citations

Hexokinase receptor complex in hepatoma mitochondria: evidence from N,N'-dicyclohexlycarbodiimide-labeling studies for the involvement of the pore-forming protein VDAC

1986 • 210 citations

Role of porins in outer membrane permeability

1987 • 206 citations

Korrelation des unspezifisch permeablen mitochondrialen Raumes mit dem „Intermembran‐Raum”

1968 • 193 citations

Contact sites between mitochondrial envelope membranes. Structure and function in energy- and protein-transfer

1991 • 187 citations

Mapping of the protein import machinery in the mitochondrial outer membrane by crosslinking of translocation intermediates

1992 • 185 citations

Identification and characterization of the pore-forming protein in the outer membrane of rat liver mitochondria

1982 • 184 citations

Purification and Characterisation of a Pore Protein of the Outer Mitochondrial Membrane from Neurospora crassa

1982 • 179 citations

The mitochondrial permeability transition pore may comprise VDAC molecules

1993 • 166 citations

Molecular cloning and sequencing of cDNA for yeast porin, an outer mitochondrial membrane protein: a search for targeting signal in the primary structure.

1985 • 164 citations

Structure predictions of membrane proteins are not that bad

1990 • 163 citations

Mitochondrial porin of Neurospora crassa: cDNA cloning, in vitro expression and import into mitochondria.

1987 • 163 citations

Cardiolipin is synthesized on the matrix side of the inner membrane in rat liver mitochondria.

1993 • 161 citations

Purification of a hexokinase-binding protein from the outer mitochondrial membrane.

1979 • 161 citations

The mitochondrial outer membrane channel, VDAC, is regulated by a synthetic polyanion

1987 • 150 citations

Further characterization of contact sites from mitochondria of different tissues: topology of peripheral kinases

1989 • 149 citations

Toward the molecular structure of the mitochondrial channel, VDAC

1992 • 149 citations

The cationically selective state of the mitochondrial outer membrane pore: a study with intact mitochondria and reconstituted mitochondrial porin

1990 • 147 citations

Structural architecture of an outer membrane channel as determined by electron crystallography

1991 • 145 citations

Properties of the inner membrane anion channel in intact mitochondria

1992 • 139 citations

Pore size and properties of channels from mitochondria isolated fromNeurospora crassa

1980 • 136 citations

The outer membrane of yeast mitochondria: isolation of outside-out sealed vesicles

1983 • 133 citations

Voltage-dependent kinetics of an anionic channel of large unit conductance in macrophages and myotube membranes

1984 • 133 citations

Changes in freeze-fractured mitochondrial membranes correlated to their energetic state

1983 • 132 citations

Widening potential for Ca2+ antagonists: non-L-type Ca2+ channel interaction

1990 • 130 citations

Pore‐forming activity in the outer membrane of the chloroplast envelope

1984 • 128 citations

Biophysics of the structure and function of porins

1990 • 127 citations

Porin pores of mitochondrial outer membranes from high and low eukaryotic cells: biochemical and biophysical characterization

1987 • 127 citations

Peptide-specific antibodies and proteases as probes of the transmembrane topology of the bovine heart mitochondrial porin

1991 • 125 citations

Channels in Mitochondrial Membranes: Knowns, Unknowns, and Prospects for the Future

1993 • 123 citations

Inhibition of adenine nucleotide transport through the mitochondrial porin by a synthetic polyanion

1988 • 121 citations

Molecular genetics of the VDAC ion channel: Structural model and sequence analysis

1987 • 121 citations

The functional compartmentation of mitochondrial hexokinase

1974 • 120 citations

Glucose phosphorylation in tumor cells. Cloning, sequencing, and overexpression in active form of a full-length cDNA encoding a mitochondrial bindable form of hexokinase.

1990 • 118 citations

Identification of a voltage-dependent anion channel in the apical membrane of a Cl?-secretory epithelium (MDCK)

1985 • 118 citations

Enrichment and biochemical characterization of boundary membrane contact sites from rat-liver mitochondria

1986 • 117 citations

Biosynthesis of Mitochondrial Porin and Insertion into the Outer Mitochondrial Membrane of Neuruspora crassa

1982 • 113 citations

Mitochondrial import receptors for precursor proteins

1991 • 112 citations

[9] Proteins forming large channels from bacterial and mitochondrial outer membranes: Porins and phage lambda receptor protein

1983 • 110 citations

Compartmentation of Heart Mitochondria

1965 • 110 citations

Interaction of non‐classical detergents with the mitochondrial porin

1989 • 108 citations

Import of proteins into mitochondria. In vitro studies on the biogenesis of the outer membrane.

1983 • 102 citations

A simple and rapid method for the purification of the mitochondrial porin from mammalian tissues

1987 • 98 citations

A water-soluble form of porin from the mitochondrial outer membrane of Neurospora crassa. Properties and relationship to the biosynthetic precursor form.

1985 • 97 citations

Modulation of inner mitochondrial membrane channel activity

1992 • 97 citations

A yeast mutant lacking mitochondrial porin is respiratory-deficient, but can recover respiration with simultaneous accumulation of an 86-kd extramitochondrial protein.

1987 • 92 citations

Purification of a protein having pore forming activity from the rat liver mitochondrial outer membrane

1982 • 92 citations

Purification, functional characterization, and cDNA sequencing of mitochondrial porin from Dictyostelium discoideum.

1992 • 91 citations

Phospholipase-Induced Crystallization of Channels in Mitochondrial Outer Membranes

1984 • 89 citations

The 35 kDa DCCD-binding protein from pig heart mitochondria is the mitochondrial porin

1985 • 87 citations

Isolation and cloning of a voltage-dependent anion channel-like Mr 36,000 polypeptide from mammalian brain.

1992 • 86 citations

Voltage activation of heart inner mitochondrial membrane channels

1992 • 81 citations

Electrophysiological characterization of contact sites in brain mitochondria.

1990 • 79 citations

The binding of glycerol kinase to the outer membrane of rat liver mitochondria: Its importance in metabolic regulation

1983 • 77 citations

The mitochondrial benzodiazepine receptor: Evidence for association with the voltage-dependent anion channel (VDAC)

1992 • 76 citations

Studies on Human Porin. VI. Production and Characterization of Eight Monoclonal Mouse Antibodies against the Human VDAC “Porin 31HL” and Their Application for Histotopological Studies in Human Skeletal Muscle

1991 • 76 citations

Modulation of potassium channels in human T lymphocytes: effects of temperature.

1990 • 75 citations

The mitochondrial inner membrane anion channel. Regulation by divalent cations and protons.

1987 • 74 citations

Effect of macromolecules on the regulation of the mitochondrial outer membrane pore and the activity of adenylate kinase in the inter-membrane space

1993 • 72 citations

Voltage gating of the mitochondrial outer membrane channel VDAC is regulated by a very conserved protein

1991 • 69 citations

Sizing of an ion pore by access resistance measurements

1992 • 68 citations

A large, multiple-conductance chloride channel in normal human T lymphocytes

1990 • 68 citations

The slow rise of the flash-light-induced alkalization by Photosystem II of the suspending medium of thylakoids is reversibly related to thylakoid stacking

1986 • 68 citations

Effect of macromolecules on the structure of the mitochondrial inter-membrane space and the regulation of hexokinase

1993 • 68 citations

Transmembrane arrangement of mitochondrial porin or voltage-dependent anion channel (VDAC)

1992 • 66 citations

A mitochondrial porin cDNA predicts the existence of multiple human porins

1993 • 66 citations

Surface topography and molecular stoichiometry of the mitochondrial channel, VDAC, in crystalline arrays*1

1991 • 65 citations

Pore formation by the mitochondrial porin of rat brain in lipid bilayer membranes

1986 • 64 citations

Incorporation in lipid bilayers of a large conductance cationic channel from mitochondrial membranes.

1988 • 63 citations

Hexokinase of rat brain mitochondria: Relative importance of adenylate kinase and oxidative phosphorylation as sources of substrate ATP, and interaction with intramitochondrial compartments of ATP and ADP

1991 • 61 citations

Hydrodynamic properties of porin isolated from outer membranes of rat liver mitochondria

1983 • 60 citations

A soluble mitochondrial protein increases the voltage dependence of the mitochondrial channel, VDAC

1992 • 59 citations

Patch clamping the outer mitochondrial membrane

1987 • 59 citations

Patch clamping VDAC in liposomes containing whole mitochondrial membranes

1991 • 58 citations

Cross-linking analysis of yeast mitochondrial outer membrane

1986 • 57 citations

Cl? channels in intact human T lymphocytes

1992 • 57 citations

Zur Kenntnis der Porine des Menschen

1989 • 56 citations

Subfractionation of the outer membrane of rat brain mitochondria: Evidence for the existence of a domain containing the porin-hexokinase complex

1987 • 55 citations

On the Regulation of the Mitochondrial Inner Membrane Anion Channel by Magnesium and Protons

1989 • 55 citations

Further investigation on the high-conductance ion channel of the inner membrane of mitochondria

1989 • 53 citations

The cation-selective substate of the mitochondrial outer membrane pore: Single-channel conductance and influence on intermembrane and peripheral kinases

1992 • 53 citations

Voltage-Dependent Channels Found in the Membrane Fraction of Corn Mitochondria

1985 • 53 citations

An SS1–SS2 β-barrel structure for the voltage-activated potassium channel

1992 • 52 citations

Identification of a new pore in the mitochondrial outer membrane of a porin‐deficient yeast mutant

1989 • 51 citations

Interaction of a synthetic polyanion with rat liver mitochondria

1977 • 51 citations

Location of the dicyclohexylcarbodiimide-reactive glutamate residue in the bovine heart mitochondrial porin

1993 • 51 citations

The Evolution of Ion Pumps

1985 • 50 citations

Interaction between the VDAC channel and a polyanionic effector. An electron microscopic study

1990 • 49 citations

Comparison of mitochondrial cationic channels in wild-type and porin-deficient mutant yeast

1990 • 49 citations

Topology of PhoE porin: the ‘eyelet’ region

1993 • 48 citations

Regulation of mitochondrial hexokinase in cultured HT 29 human cancer cells. An ultrastructural and biochemical study

1987 • 47 citations

Characterization of the mitochondrial porin from Drosophila melanogaster

1989 • 47 citations

Structure of the Channels in the Outer Mitochondrial Membrane

1986 • 45 citations

Studies on Human Porin. VII. The Channel Properties of the Human B-Lymphocyte Membrane-Derived “Porin 31HL” are Similar to those of Mitochondrial Porins

1992 • 45 citations

Diameter of the mitochondrial outer membrane channel: Evidence from electron microscopy of frozen‐hydrated membrane crystals

1989 • 44 citations

Purification and characterization of the pore forming protein of yeast mitochondrial outer membrane

1988 • 44 citations

A peptide‐sensitive channel of large conductance is localized on mitochondrial outer membrane

1991 • 44 citations

Determination of the number of polypeptide subunits in a functional VDAC channel fromSaccharomyces cerevisiae

1992 • 44 citations

Hexokinase receptors: Preferential enzyme binding in normal cells to nonmitochondrial sites and in transformed cells to mitochondrial sites

1992 • 41 citations

Porin of Paramecium mitochondria isolation, characterization and ion selectivity of the closed state

1989 • 39 citations

Glucose catabolism in brain. Intracellular localization of hexokinase.

1990 • 39 citations

Structural analysis of mitochondrial pores

1990 • 38 citations

The respiration of cells and mitochondria of porin deficient yeast mutants is coupled

1990 • 37 citations

A study of structure of the mitochondrial membrane system

1966 • 36 citations

Mitochondrial Hexokinase in Brain of Various Species: Differences in Sensitivity to Solubilization by Glucose 6-Phosphate

1993 • 35 citations

Higher plant cell respiration

1986 • 35 citations

Voltage gating in porin channels

1987 • 32 citations

Purification and Characterization of the Voltage-Dependent Anion-Selective Channel Protein from Wheat Mitochondrial Membranes

1993 • 32 citations

Identification of anion and cation pathways in the inner mitochondrial membrane by patch clamping of mouse liver mitoplasts

1991 • 32 citations

The Inner Boundary Membrane of Mitochondria. Localization and Biochemical Characterization, Possible Functions in Biogenesis and Metabolism

1974 • 31 citations

Intracellular localization of rat kidney hexokinase. Evidence for an association with low density mitochondria.

1984 • 31 citations

Purification and Characterization of Porin from Corn (Zea mays L.) Mitochondria

1993 • 31 citations

Evidence for a novel voltage‐activated channel in the outer mitochondrial membrane

1987 • 30 citations

Isolation of mitochondrial porin from Neurospora crassa

1982 • 30 citations

Ionic permeability of the mitochondrial outer membrane

1992 • 28 citations

In vitro trimerization of outer membrane protein PhoE

1990 • 28 citations

Puromycin Sensitivity of Ribosomal Label after Incorporation of 14C-Labelled Amino Acids into Isolated Mitochondria from Neurospora crassa

1969 • 27 citations

Identification of two general diffusion channels in the outer membrane of pea mitochondria

1992 • 27 citations

Characterization of pore-forming activity in liver mitochondria from Anguilla anguilla. Two porins in mitochondria?

1991 • 26 citations

Pores from mitochondrial outer membranes of yeast and a porin-deficient yeast mutant: A comparison

1989 • 26 citations

Inhibition of mitochondrial substrate anion translocators by a synthetic amphipathic polyanion

1982 • 25 citations

Anion Carriers of Mitochondrial Membranes.

1990 • 24 citations

Characterization of a large conductance non-selective anion channel in B lymphocytes

1989 • 24 citations

SEPARATION OF MITOCHONDRIAL MEMBRANES OF NEUROSPORA CRASSA

1971 • 24 citations

Cytochrome c binds to lipid domains in arrays of mitochondrial outer membrane channels

1987 • 24 citations

High-conductance pathways in mitochondrial membranes

1992 • 23 citations

The cytochromec reductase/oxidase respiratory pathway ofParacoccus denitrificans: Genetic and functional studies

1991 • 21 citations

Biogenesis of mitochondrial porin: The import pathway

1990 • 21 citations

Properties of channels in the mitochondrial outer membrane

1989 • 19 citations

Separate [³H]‐nitrendipine binding sites in mitochondria and plasma membranes of bovine adrenal medulla

1990 • 17 citations

Binding of a synthetic targeting peptide to a mitochondrial channel protein

1992 • 15 citations

Characterization of the submitochondrial compartments: Study of the site of synthesis of dolichol and dolichol-linked sugars

1989 • 15 citations

Kinetics of voltage-induced conductance increases in the outer mitochondrial membrane

1989 • 13 citations

A mechanism for the RNA‐catalyzed formation of 5′‐phosphates The origin of nucleases

1987 • 12 citations

Intermembrane space in mitochondria and the mechanism(s) of oxidative phosphorylation

1983 • 7 citations