CPEB regulation of human cellular senescence, energy metabolism, and p53 mRNA translation

Why do cancers have high aerobic glycolysis?

2004 • 4,534 citations

Cellular senescence: when bad things happen to good cells

2007 • 3,933 citations

BRAFE600-associated senescence-like cell cycle arrest of human naevi

2005 • 2,054 citations

Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis

2005 • 1,893 citations

p53 Regulates Mitochondrial Respiration

2006 • 1,600 citations

Mitogenic Signaling Mediated by Oxidants in Ras-Transformed Fibroblasts

1997 • 1,582 citations

Senescence in premalignant tumours

2005 • 1,394 citations

Reversal of human cellular senescence: roles of the p53 and p16 pathways

2003 • 1,342 citations

Intrinsic tumour suppression

2004 • 1,267 citations

Oncogene-induced senescence as an initial barrier in lymphoma development

2005 • 1,153 citations

MicroRNAs direct rapid deadenylation of mRNA

2006 • 1,114 citations

The signals and pathways activating cellular senescence

2004 • 1,003 citations

p53 Deficiency Rescues the Adverse Effects of Telomere Loss and Cooperates with Telomere Dysfunction to Accelerate Carcinogenesis

1999 • 969 citations

Circularization of mRNA by Eukaryotic Translation Initiation Factors

1998 • 940 citations

Oncogenic BRAF Induces Senescence and Apoptosis through Pathways Mediated by the Secreted Protein IGFBP7

2008 • 846 citations

Association of the yeast poly(A) tail binding protein with translation initiation factor eIF-4G.

1996 • 679 citations

Hayflick, his limit, and cellular ageing

2000 • 674 citations

Translational control in biology and medicine

2007 • 665 citations

Ras Proteins Induce Senescence by Altering the Intracellular Levels of Reactive Oxygen Species

1999 • 661 citations

Regulation of p53 Translation and Induction after DNA Damage by Ribosomal Protein L26 and Nucleolin

2005 • 627 citations

Species- and cell type-specific requirements for cellular transformation

2004 • 542 citations

CPEB: a life in translation

2007 • 506 citations

CPEB-Mediated Cytoplasmic Polyadenylation and the Regulation of Experience-Dependent Translation of α-CaMKII mRNA at Synapses

1998 • 485 citations

Methods to Detect Biomarkers of Cellular Senescence

2007 • 453 citations

RNA-binding protein HuR enhances p53 translation in response to ultraviolet light irradiation

2003 • 440 citations

Regulation of Tumor Cell Mitochondrial Homeostasis by an Organelle-Specific Hsp90 Chaperone Network

2007 • 420 citations

Maskin Is a CPEB-Associated Factor that Transiently Interacts with eIF-4E

1999 • 379 citations

Erosion of the telomeric single-strand overhang at replicative senescence

2003 • 332 citations

Symplekin and xGLD-2 Are Required for CPEB-Mediated Cytoplasmic Polyadenylation

2004 • 325 citations

Translation initiation factor eIF4G mediates in vitro poly(A) tail-dependent translation

1997 • 314 citations

p53: new roles in metabolism

2007 • 294 citations

Opposing Polymerase-Deadenylase Activities Regulate Cytoplasmic Polyadenylation

2006 • 293 citations

Alterations in p53 and p16^INK4 Expression and Telomere Length during Spontaneous Immortalization of Li-Fraumeni Syndrome Fibroblasts

1995 • 248 citations

Phosphorylation of CPEB by Eg2 Mediates the Recruitment of CPSF into an Active Cytoplasmic Polyadenylation Complex

2000 • 238 citations

Germ Cell Differentiation and Synaptonemal Complex Formation Are Disrupted in CPEB Knockout Mice

2001 • 231 citations

A PtdIns4,5P2-regulated nuclear poly(A) polymerase controls expression of select mRNAs

2008 • 227 citations

Immunoprecipitation of mRNA-protein complexes

2006 • 216 citations

New Modes of Translational Control in Development, Behavior, and Disease

2007 • 210 citations

Regulation of cellular response to oncogenic and oxidative stress by Seladin-1

2004 • 193 citations

Specificity of RNA Binding by CPEB: Requirement for RNA Recognition Motifs and a Novel Zinc Finger

1998 • 175 citations

Cell-cycle related regulation of poly(A) polymerase by phosphorylation

1996 • 164 citations

Immortalisation and transformation revisited

2002 • 127 citations

RINGO/cdk1 and CPEB mediate poly(A) tail stabilization and translational regulation by ePAB

2007 • 115 citations

Rapid and sensitive analysis of mRNA polyadenylation states by PCR.

1995 • 108 citations

Translation-independent inhibition of mRNA deadenylation during stress in Saccharomyces cerevisiae

2006 • 96 citations

Control of cellular senescence by CPEB

2006 • 94 citations

Loss of retinoblastoma but not p16 function allows bypass of replicative senescence in human fibroblasts

2003 • 82 citations

Replicative Senescence, Aging and Growth-Regulatory Transcription Factors

1996 • 76 citations

Differential Phosphorylation Controls Maskin Association with Eukaryotic Translation Initiation Factor 4E and Localization on the Mitotic Apparatus

2005 • 76 citations

Regulated CPEB phosphorylation during meiotic progression suggests a mechanism for temporal control of maternal mRNA translation

2003 • 61 citations

Oncogenes and senescence: breaking down in the fast lane

2007 • 61 citations

Poly(A) Polymerase and the Regulation of Cytoplasmic Polyadenylation

2001 • 58 citations

Loss of one p53 allele results in four-fold reduction of p53 mRNA and protein: a basis for p53 haplo-insufficiency

2006 • 54 citations

CDK1 and calcineurin regulate Maskin association with eIF4E and translational control of cell cycle progression

2006 • 53 citations

Effect of Dichloroacetate on Recovery of Brain Lactate, Phosphorus Energy Metabolites, and Glutamate during Reperfusion after Complete Cerebral Ischemia in Rats

1992 • 45 citations

Oxidative stress induces a prolonged but reversible arrest in p53-null cancer cells, involving a Chk1-dependent G2 checkpoint

2006 • 45 citations

Cryptic Translocation Identification in Human and Mouse Using Several Telomeric Multiplex FISH (TM-FISH) Strategies

2001 • 30 citations

Ras and Rac as Activators of Reactive Oxygen Species (ROS)

2003 • 29 citations

Translational control of synaptic plasticity and learning and memory

2007 • 21 citations