Control of cellular senescence by CPEB

A biomarker that identifies senescent human cells in culture and in aging skin in vivo.

1995 • 6,950 citations

Oncogenic ras Provokes Premature Cell Senescence Associated with Accumulation of p53 and p16INK4a

1997 • 4,870 citations

Production of high-titer helper-free retroviruses by transient transfection.

1993 • 2,280 citations

Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line

1990 • 2,129 citations

BRAFE600-associated senescence-like cell cycle arrest of human naevi

2005 • 2,054 citations

Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis

2005 • 1,893 citations

Senescence in premalignant tumours

2005 • 1,394 citations

Decapping and Decay of Messenger RNA Occur in Cytoplasmic Processing Bodies

2003 • 1,323 citations

Mammalian cyclin-dependent kinases

2005 • 1,201 citations

Oncogene-induced senescence as an initial barrier in lymphoma development

2005 • 1,153 citations

Living with or without cyclins and cyclin-dependent kinases

2004 • 1,047 citations

Principles of Tumor Suppression

2004 • 1,017 citations

The signals and pathways activating cellular senescence

2004 • 1,003 citations

Regulation of cap-dependent translation by eIF4E inhibitory proteins

2005 • 944 citations

Safe and efficient generation of recombinant retroviruses with amphotropic and ecotropic host ranges.

1988 • 908 citations

Loss of p16Ink4a with retention of p19Arf predisposes mice to tumorigenesis

2001 • 825 citations

Cell-cycle control of c-myc but not c-ras expression is lost following chemical transformation

1984 • 785 citations

Movement of Eukaryotic mRNAs Between Polysomes and Cytoplasmic Processing Bodies

2005 • 754 citations

General Translational Repression by Activators of mRNA Decapping

2005 • 630 citations

Targeted disruption of the three Rb-related genes leads to loss of G₁ control and immortalization

2000 • 583 citations

The translation factor eIF-4E promotes tumor formation and cooperates with c-Myc in lymphomagenesis

2004 • 573 citations

Cancer and ageing: rival demons?

2003 • 498 citations

CPEB-Mediated Cytoplasmic Polyadenylation and the Regulation of Experience-Dependent Translation of α-CaMKII mRNA at Synapses

1998 • 485 citations

Mammalian poly(A)-binding protein is a eukaryotic translation initiation factor, which acts via multiple mechanisms

2005 • 484 citations

CPEB is a specificity factor that mediates cytoplasmic polyadenylation during Xenopus oocyte maturation

1994 • 451 citations

Maskin Is a CPEB-Associated Factor that Transiently Interacts with eIF-4E

1999 • 379 citations

Phosphorylation of CPE binding factor by Eg2 regulates translation of c-mos mRNA

2000 • 373 citations

Symplekin and xGLD-2 Are Required for CPEB-Mediated Cytoplasmic Polyadenylation

2004 • 325 citations

C-Myc 5′ untranslated region contains an internal ribosome entry segment

1998 • 319 citations

c-Myc Regulates Cyclin D-Cdk4 and -Cdk6 Activity but Affects Cell Cycle Progression at Multiple Independent Points

1999 • 319 citations

THE MANY ROLES OF c-Myc IN APOPTOSIS

1998 • 310 citations

The translational regulator CPEB1 provides a link between dcp1 bodies and stress granules

2005 • 293 citations

Immunoaffinity Purification of Mammalian Protein Complexes

2003 • 278 citations

CPEB, Maskin, and Cyclin B1 mRNA at the Mitotic Apparatus

2000 • 275 citations

Germ Cell Differentiation and Synaptonemal Complex Formation Are Disrupted in CPEB Knockout Mice

2001 • 231 citations

Dissolution of the maskin-eIF4E complex by cytoplasmic polyadenylation and poly(A)-binding protein controls cyclin B1 mRNA translation and oocyte maturation

2002 • 217 citations

Translational Control of the Embryonic Cell Cycle

2002 • 200 citations

[40] Biological assays for Ras transformation

1995 • 199 citations

Analysis of the c-myc IRES; a potential role for cell-type specific trans-acting factors and the nuclear compartment

2000 • 190 citations

Differential mRNA translation and meiotic progression require Cdc2-mediated CPEB destruction

2002 • 180 citations

Specificity of RNA Binding by CPEB: Requirement for RNA Recognition Motifs and a Novel Zinc Finger

1998 • 175 citations

Contributions of Myc to tumorigenesis

2002 • 175 citations

Selective Modulation of Some Forms of Schaffer Collateral-CA1 Synaptic Plasticity in Mice With a Disruption of the CPEB-1 Gene

2004 • 158 citations

Regulation of cell cycle duration by c-myc levels.

1989 • 155 citations

A conserved role of a DEAD box helicase in mRNA masking

2001 • 143 citations

Mammalian GLD-2 homologs are poly(A) polymerases

2004 • 140 citations

Mouse cytoplasmic polyadenylylation element binding protein: An evolutionarily conserved protein that interacts with the cytoplasmic polyadenylylation elements of c- mos mRNA

1996 • 116 citations

Reduced extinction of hippocampal-dependent memories in CPEB knockout mice

2006 • 111 citations

Translational Control by Neuroguidin, a Eukaryotic Initiation Factor 4E and CPEB Binding Protein

2006 • 108 citations

Escape from premature senescence is not sufficient for oncogenic transformation by Ras

2001 • 101 citations

Differential Phosphorylation Controls Maskin Association with Eukaryotic Translation Initiation Factor 4E and Localization on the Mitotic Apparatus

2005 • 76 citations

The thorny path linking cellular senescence to organismal aging

2005 • 74 citations

Regulated CPEB phosphorylation during meiotic progression suggests a mechanism for temporal control of maternal mRNA translation

2003 • 61 citations

Analysis of Ribosome Loading onto mRNA Species

1997 • 34 citations