Oncogenes and senescence: breaking down in the fast lane

The serial cultivation of human diploid cell strains

1961 • 7,886 citations

Telomeres shorten during ageing of human fibroblasts

1990 • 5,530 citations

Oncogenic ras Provokes Premature Cell Senescence Associated with Accumulation of p53 and p16INK4a

1997 • 4,870 citations

Induction of apoptosis in fibroblasts by c-myc protein

1992 • 2,977 citations

DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis

2005 • 2,633 citations

A DNA damage checkpoint response in telomere-initiated senescence

2003 • 2,600 citations

Rb-Mediated Heterochromatin Formation and Silencing of E2F Target Genes during Cellular Senescence

2003 • 2,104 citations

BRAFE600-associated senescence-like cell cycle arrest of human naevi

2005 • 2,054 citations

Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions

2005 • 1,975 citations

Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis

2005 • 1,893 citations

Tumor Suppression at the Mouse INK4a Locus Mediated by the Alternative Reading Frame Product p19

1997 • 1,568 citations

Senescence in premalignant tumours

2005 • 1,394 citations

Intrinsic tumour suppression

2004 • 1,267 citations

Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization

1998 • 1,248 citations

Oncogene-induced senescence as an initial barrier in lymphoma development

2005 • 1,153 citations

The alternative product from the human CDKN2A locus, p14ARF, participates in a regulatory feedback loop with p53 and MDM2

1998 • 1,152 citations

A Senescence Program Controlled by p53 and p16INK4a Contributes to the Outcome of Cancer Therapy

2002 • 1,009 citations

c-Myc Can Induce DNA Damage, Increase Reactive Oxygen Species, and Mitigate p53 Function

2002 • 845 citations

Stabilization of the p53 tumor suppressor is induced by adenovirus 5 E1A and accompanies apoptosis.

1993 • 677 citations

Ras Proteins Induce Senescence by Altering the Intracellular Levels of Reactive Oxygen Species

1999 • 661 citations

E1A signaling to p53 involves the p19^ARFtumor suppressor

1998 • 614 citations

Methylation of Histone H4 Lysine 20 Controls Recruitment of Crb2 to Sites of DNA Damage

2004 • 542 citations

Relocalization of Telomeric Ku and SIR Proteins in Response to DNA Strand Breaks in Yeast

1999 • 458 citations

Evasion of the p53 tumour surveillance network by tumour-derived MYC mutants

2005 • 452 citations

The DNA damage signaling pathway is a critical mediator of oncogene-induced senescence

2007 • 394 citations

The evolution of diverse biological responses to DNA damage: insights from yeast and p53

2001 • 372 citations

Role of the RB1 family in stabilizing histone methylation at constitutive heterochromatin

2005 • 333 citations

MEC1-Dependent Redistribution of the Sir3 Silencing Protein from Telomeres to DNA Double-Strand Breaks

1999 • 332 citations

Role of p14^ARF in Replicative and Induced Senescence of Human Fibroblasts

2001 • 217 citations

INK4a-deficient human diploid fibroblasts are resistant to RAS-induced senescence

2002 • 211 citations

Differential requirement for p19ARF in the p53-dependent arrest induced by DNA damage, microtubule disruption, and ribonucleotide depletion

2000 • 103 citations

Tumor suppressor p16INK4a determines sensitivity of human cells to transformation by cooperating cellular oncogenes

2003 • 94 citations

p14ARF is a component of the p53 response following ionizing irradiation of normal human fibroblasts

2004 • 42 citations

Differential requirement for p19ARF in the p53-dependent arrest induced by DNA damage, microtubule disruption, and ribonucleotide depletion

2000 • 15 citations