Signal Transduction Pathways Mediated by PECAM-1

The biochemistry of apoptosis

2000 • 7,314 citations

Immune Inhibitory Receptors

2000 • 1,283 citations

PECAM-1 is required for transendothelial migration of leukocytes.

1993 • 1,134 citations

PECAM-1 (CD31) Cloning and Relation to Adhesion Molecules of the Immunoglobulin Gene Superfamily

1990 • 948 citations

Angiogenesis, assessed by platelet/endothelial cell adhesion molecule antibodies, as indicator of node metastases and survival in breast cancer

1992 • 822 citations

The Talin Head Domain Binds to Integrin β Subunit Cytoplasmic Tails and Regulates Integrin Activation

1999 • 697 citations

The biology of PECAM-1.

1997 • 669 citations

The molecular organization of endothelial cell to cell junctions: differential association of plakoglobin, beta-catenin, and alpha-catenin with vascular endothelial cadherin (VE-cadherin).

1995 • 573 citations

A new function for a phosphotyrosine phosphatase: linking GRB2-Sos to a receptor tyrosine kinase

1994 • 477 citations

Involvement of Platelet-Endothelial Cell Adhesion Molecule-1 in Neutrophil Recruitment in Vivo

1993 • 468 citations

Rab GTPases, intracellular traffic and disease

2002 • 463 citations

Genetic Evidence for Functional Redundancy of Platelet/Endothelial Cell Adhesion Molecule-1 (PECAM-1): CD31-Deficient Mice Reveal PECAM-1-Dependent and PECAM-1-Independent Functions

1999 • 430 citations

The Small Gtpase, Rap1, Mediates Cd31-Induced Integrin Adhesion

2000 • 419 citations

Protein-tyrosine-phosphatase SHPTP2 couples platelet-derived growth factor receptor beta to Ras.

1994 • 389 citations

CD31 expressed on distinctive T cell subsets is a preferential amplifier of beta 1 integrin-mediated adhesion.

1992 • 383 citations

Apoptosis disables CD31-mediated cell detachment from phagocytes promoting binding and engulfment

2002 • 375 citations

Evidence for a role of platelet endothelial cell adhesion molecule-1 in endothelial cell mechanosignal transduction

2002 • 301 citations

Platelet endothelial cell adhesion molecule-1 (PECAM-1 / CD31): alternatively spliced, functionally distinct isoforms expressed during mammalian cardiovascular development

1994 • 301 citations

Monoclonal antibody to murine PECAM-1 (CD31) blocks acute inflammation in vivo.

1994 • 296 citations

Gab1 Acts as an Adapter Molecule Linking the Cytokine Receptor gp130 to ERK Mitogen-Activated Protein Kinase

1998 • 287 citations

Switched at birth: a new family for PECAM-1

1999 • 257 citations

Multiple Requirements for SHPTP2 in Epidermal Growth Factor-Mediated Cell Cycle Progression

1996 • 247 citations

Crystal Structures of the XLP Protein SAP Reveal a Class of SH2 Domains with Extended, Phosphotyrosine-Independent Sequence Recognition

1999 • 244 citations

Migration of monocytes across endothelium and passage through extracellular matrix involve separate molecular domains of PECAM-1.

1995 • 240 citations

PECAM-1 (CD31) Homophilic Interaction Up-Regulates α6β1 on Transmigrated Neutrophils In Vivo and Plays a Functional Role in the Ability of α6 Integrins to Mediate Leukocyte Migration through the Perivascular Basement Membrane

2002 • 224 citations

CD150 Association with Either the SH2-Containing Inositol Phosphatase or the SH2-Containing Protein Tyrosine Phosphatase Is Regulated by the Adaptor Protein SH2D1A

2001 • 221 citations

Molecular characterization and functional analysis of the leukocyte surface protein CD31.

1990 • 217 citations

The Protein-tyrosine Phosphatase SHP-2 Binds Platelet/Endothelial Cell Adhesion Molecule-1 (PECAM-1) and Forms a Distinct Signaling Complex during Platelet Aggregation

1997 • 215 citations

PECAM-1/CDS31, an endothelial receptor for binding Plasmodium falciparum-infected erythrocytes

1997 • 215 citations

Endothelial cell tube formation depends on cadherin 5 and CD31 interactions with filamentous actin.

1997 • 209 citations

Megakaryocytes derived from embryonic stem cells implicate CalDAG-GEFI in integrin signaling

2002 • 203 citations

Spatial and temporal relationships between cadherins and PECAM-1 in cell-cell junctions of human endothelial cells.

1994 • 196 citations

Collagen receptor signalling in platelets: extending the role of the ITAM

1998 • 189 citations

Relationships between Rap1b, Affinity Modulation of Integrin αIIbβ3, and the Actin Cytoskeleton

2002 • 189 citations

Roles of platelet/endothelial cell adhesion molecule-1 (PECAM-1, CD31) in natural killer cell transendothelial migration and beta 2 integrin activation.

1996 • 180 citations

Individually Distinct Ig Homology Domains in PECAM-1 Regulate Homophilic Binding and Modulate Receptor Affinity

1996 • 174 citations

A new function for a phosphotyrosine phosphatase: linking GRB2-Sos to a receptor tyrosine kinase.

1994 • 172 citations

Ligation of platelet/endothelial cell adhesion molecule 1 (PECAM-1/CD31) on monocytes and neutrophils increases binding capacity of leukocyte CR3 (CD11b/CD18).

1995 • 169 citations

Molecular cloning of CD31, a putative intercellular adhesion molecule closely related to carcinoembryonic antigen.

1990 • 166 citations

Signals from platelet/endothelial cell adhesion molecule enhance the adhesive activity of the very late antigen-4 integrin of human CD34+ hemopoietic progenitor cells.

1994 • 166 citations

Tyrosine phosphorylation of platelet endothelial cell adhesion molecule-1 (PECAM-1, CD31) in mechanically stimulated vascular endothelial cells.

1997 • 155 citations

A New Role for Platelet-Endothelial Cell Adhesion Molecule-1 (CD31): Inhibition of TCR-Mediated Signal Transduction

1999 • 154 citations

Characterization of Phosphotyrosine Binding Motifs in the Cytoplasmic Domain of Platelet/Endothelial Cell Adhesion Molecule-1 (PECAM-1) That Are Required for the Cellular Association and Activation of the Protein-tyrosine Phosphatase, SHP-2

1997 • 151 citations

Platelet endothelial cell adhesion molecule-1 signaling inhibits the activation of human platelets

2002 • 150 citations

Platelet Endothelial Cell Adhesion Molecule-1 (PECAM-1) Homophilic Adhesion Is Mediated by Immunoglobulin-like Domains 1 and 2 and Depends on the Cytoplasmic Domain and the Level of Surface Expression

1996 • 142 citations

Platelet endothelial cell adhesion molecule-1 serves as an inhibitory receptor that modulates platelet responses to collagen

2001 • 141 citations

Activation-dependent changes in human platelet PECAM-1: phosphorylation, cytoskeletal association, and surface membrane redistribution.

1992 • 137 citations

Requirement of SHP2 Binding to Grb2-associated Binder-1 for Mitogen-activated Protein Kinase Activation in Response to Lysophosphatidic Acid and Epidermal Growth Factor

2000 • 135 citations

Vascular endothelial cells synthesize a plasma membrane protein indistinguishable from the platelet membrane glycoprotein IIa.

1985 • 132 citations

Murine platelet endothelial cell adhesion molecule (PECAM‐1)/CD31 modulates β₂ integrins on lymphokine‐activated killer cells

1993 • 131 citations

Residues on Both Faces of the First Immunoglobulin Fold Contribute to Homophilic Binding Sites of PECAM-1/CD31

1997 • 130 citations

Biochemistry and expression of myelomonocytic antigens.

1986 • 129 citations

Direct Binding of the Platelet Integrin αIIbβ3 (GPIIb-IIIa) to Talin

1996 • 127 citations

PECAM-1 (CD31) functions as a reservoir for and a modulator of tyrosine-phosphorylated β-catenin

1999 • 126 citations

Inhibition of antigen-receptor signaling by Platelet Endothelial Cell Adhesion Molecule-1 (CD31) requires functional ITIMs, SHP-2, and p56lck

2001 • 126 citations

Platelet endothelial cell adhesion molecule-1 is a negative regulator of platelet-collagen interactions

2001 • 123 citations

Platelet-Endothelial Cell Adhesion Molecule-1 (CD31), a Scaffolding Molecule for Selected Catenin Family Members Whose Binding Is Mediated by Different Tyrosine and Serine/Threonine Phosphorylation

2000 • 121 citations

Transmigration of CD34+ Cells Across Specialized and Nonspecialized Endothelium Requires Prior Activation by Growth Factors and Is Mediated by PECAM-1 (CD31)

1998 • 120 citations

Flt3 Ligand Induces Tyrosine Phosphorylation of Gab1 and Gab2 and Their Association with Shp-2, Grb2, and PI3 Kinase

2000 • 117 citations

Recruitment and Activation of SHP-1 Protein-tyrosine Phosphatase by Human Platelet Endothelial Cell Adhesion Molecule-1 (PECAM-1)

1998 • 116 citations

Biosynthesis and processing of the cell adhesion molecule PECAM-1 includes production of a soluble form.

1994 • 113 citations

Vascular endothelial platelet endothelial adhesion molecule-1 (PECAM-1) expression is decreased by TNF-alpha and IFN-gamma. Evidence for cytokine-induced destabilization of messenger ribonucleic acid transcripts in bovine endothelial cells.

1996 • 107 citations

Platelet endothelial cell adhesion molecule-1 (PECAM-1/CD31) acts as a regulator of B-cell development, B-cell antigen receptor (BCR)–mediated activation, and autoimmune disease

2002 • 107 citations

The Protein-tyrosine Phosphatase SHP-2 Associates with Tyrosine-phosphorylated Adhesion Molecule PECAM-1 (CD31)

1997 • 106 citations

Differential association of cytoplasmic signalling molecules SHP‐1, SHP‐2, SHIP and phospholipase C‐γ1 with PECAM‐1/CD31

1999 • 103 citations

Integrin engagement mediates tyrosine dephosphorylation on platelet-endothelial cell adhesion molecule 1.

1996 • 102 citations

Regulation of Mouse PECAM-1 Tyrosine Phosphorylation by the Src and Csk Families of Protein-tyrosine Kinases

1998 • 101 citations

Platelet endothelial cell adhesion molecule‐1 is a major SH‐PTP2 binding protein in vascular endothelial cells

1997 • 101 citations

Platelet Endothelial Cell Adhesion Molecule-1 Is Phosphorylatable by c-Src, Binds Src-Src homology 2 Domain, and Exhibits Immunoreceptor Tyrosine-based Activation Motif-like Properties

1997 • 99 citations

A novel leukocyte differentiation antigen: two monoclonal antibodies TM2 and TM3 define a 120-kd molecule present on neutrophils, monocytes, platelets, and activated lymphoblasts

1985 • 96 citations

Platelet/Endothelial Cell Adhesion Molecule-1 Serves as a Costimulatory Agonist Receptor That Modulates Integrin-Dependent Adhesion and Aggregation of Human Platelets

1998 • 94 citations

The cell adhesion molecule CD31 is phosphorylated after cell activation. Down-regulation of CD31 in activated T lymphocytes.

1992 • 93 citations

Molecular cloning and adhesive properties of murine platelet/endothelial cell adhesion molecule 1.

1993 • 90 citations

SHP-2, SH2-containing protein tyrosine phosphatase-21Due to the limitation of references we would like to apologize to all authors that contributed important results to the elucidation of the biological function of SHP-2 and could not be mentioned in this review.1

1998 • 88 citations

Organization of the gene for human platelet/endothelial cell adhesion molecule-1 shows alternatively spliced isoforms and a functionally complex cytoplasmic domain

1994 • 87 citations

Alternative Splicing of a Specific Cytoplasmic Exon Alters the Binding Characteristics of Murine Platelet/Endothelial Cell Adhesion Molecule-1 (PECAM-1)

1995 • 85 citations

Homophilic PECAM-1(CD31) interactions prevent endothelial cell apoptosis but do not support cell spreading or migration

1999 • 82 citations

Functional Association of Platelet Endothelial Cell Adhesion Molecule-1 and Phosphoinositide 3-Kinase in Human Neutrophils

1998 • 81 citations

Thrombospondin-1, a natural inhibitor of angiogenesis, regulates platelet-endothelial cell adhesion molecule-1 expression and endothelial cell morphogenesis.

1997 • 80 citations

Src Homology 2 Domain-Containing Protein-Tyrosine Phosphatases, SHP-1 and SHP-2, Are Required for Platelet Endothelial Cell Adhesion Molecule-1/CD31-Mediated Inhibitory Signaling

2001 • 79 citations

Role of Platelet-Endothelial Cell Adhesion Molecule (PECAM) in Platelet Adhesion/Aggregation Over Injured but Not Denuded Endothelium In Vivo and Ex Vivo

1996 • 75 citations

Inner Cell Mass-Specific Expression of a Cell Adhesion Molecule (PECAM-1/CD31) in the Mouse Blastocyst

2001 • 75 citations

Antibody against murine PECAM-1 inhibits tumor angiogenesis in mice.

1999 • 74 citations

Monocytes Stimulate Expression of the Bcl-2 Family Member, A1, in Endothelial Cells and Confer Protection Against Apoptosis

1999 • 72 citations

Ligation of CD31 (PECAM-1) on Endothelial Cells Increases Adhesive Function of vβ3 Integrin and Enhances β1 Integrin-Mediated Adhesion of Eosinophils to Endothelial Cells

1999 • 70 citations

Collagen, convulxin and thrombin stimulate aggregation-independent tyrosine phosphorylation of CD31 in platelets: evidence for the involvement of Src-family kinases

2000 • 69 citations

PECAM-1–dependent neutrophil transmigration is independent of monolayer PECAM-1 signaling or localization

2003 • 64 citations

Collagen, Convulxin, and Thrombin Stimulate Aggregation-independent Tyrosine Phosphorylation of CD31 in Platelets

2000 • 62 citations

Aggregation of the High Affinity IgE Receptor Results in the Tyrosine Phosphorylation of the Surface Adhesion Protein PECAM-1 (CD31)

1997 • 58 citations

Integrin Activation by Regulated Dimerization and Oligomerization of Platelet Endothelial Cell Adhesion Molecule (Pecam)-1 from within the Cell

2001 • 57 citations

Platelet Endothelial Cell Adhesion Molecule 1 (PECAM-1/CD31): A Multifunctional Vascular Cell Adhesion Molecule

1997 • 52 citations

Tissue specific expression of alternatively spliced Murine PECAM-1 isoforms

1999 • 52 citations

Absence of Platelet Endothelial Cell Adhesion Molecule-1 (CD31) Leads to Increased Severity of Local and Systemic IgE-Mediated Anaphylaxis and Modulation of Mast Cell Activation

2002 • 51 citations

Fluid Flow and Osmotic Stress Induce Tyrosine Phosphorylation of an Endothelial Cell 128-kDa Surface Glycoprotein

1995 • 49 citations

Anti-CD31 delays platelet adhesion/aggregation at sites of endothelial injury in mouse cerebral arterioles.

1994 • 48 citations

SIGNALING THROUGH CD31 PROTECTS ENDOTHELIAL CELLS FROM APOPTOSIS

2001 • 46 citations

Lack of In Vivo Function of CD31 in Vascular Thrombosis

2001 • 46 citations

Identification of natural ligands for SH2 domains from a phage display cDNA library

2000 • 44 citations

CD31‐triggered rearrangement of the actin cytoskeleton in human natural killer cells

1996 • 43 citations

Expression of PECAM-1/CD31 isoforms in human brain gliomas.

1999 • 43 citations

Glucose-induced transmigration of monocytes is linked to phosphorylation of PECAM-1 in cultured endothelial cells

1996 • 42 citations

Differential Modulation of Cadherin-mediated Cell–Cell Adhesion by Platelet Endothelial Cell Adhesion Molecule-1 Isoforms through Activation of Extracellular Regulated Kinases

2000 • 39 citations

Cobalt chloride-induced signaling in endothelium leading to the augmented adherence of sickle red blood cells and transendothelial migration of monocyte-like HL-60 cells is blocked by PAF-receptor antagonist

1999 • 39 citations

PECAM-1 Is a Modulator of STAT Family Member Phosphorylation and Localization: Lessons from a Transgenic Mouse

2001 • 37 citations

Tyrosine phosphorylation of P-selectin in intact platelets and in a disulphide-linked complex with immunoprecipitated pp60c-src

1994 • 36 citations

Nitration of PECAM-1 ITIM tyrosines abrogates phosphorylation and SHP-2 binding

2002 • 36 citations

Endothelial Cells and Normal Circulating Haemopoietic Cells Share a Number of Surface Antigens

1989 • 36 citations

Tissue-specific distributions of alternatively spliced human PECAM-1 isoforms

2003 • 36 citations

Expression pattern of alternatively spliced PECAM‐1 isoforms in hematopoietic cells and platelets

2002 • 35 citations

Transendothelial migration induces rapid expression on neutrophils of granule-release VLA6 used for tissue infiltration

1997 • 35 citations

Functional regulation of platelet/endothelial cell adhesion molecule-1 by TGF-beta 1 in promonocytic U-937 cells.

1994 • 33 citations

Wheat Germ Agglutinin-Induced Platelet Activation via Platelet Endothelial Cell Adhesion Molecule-1: Involvement of Rapid Phospholipase Cγ2 Activation by Src Family Kinases

2001 • 32 citations

Thrombin-induced association of SHP-2 with multiple tyrosine-phosphorylated proteins in human platelets

1999 • 31 citations

Binding Properties and Inhibition of Platelet Aggregation by a Monoclonal Antibody to CD31 (PECAM-1)

1997 • 25 citations

B cell differentiation antigens

1983 • 18 citations