Platelet Endothelial Cell Adhesion Molecule 1 (PECAM-1/CD31): A Multifunctional Vascular Cell Adhesion Molecule

PECAM-1 is required for transendothelial migration of leukocytes.

1993 • 1,134 citations

PECAM-1 (CD31) Cloning and Relation to Adhesion Molecules of the Immunoglobulin Gene Superfamily

1990 • 948 citations

Molecular and cellular properties of PECAM-1 (endoCAM/CD31): a novel vascular cell-cell adhesion molecule.

1991 • 719 citations

The biology of PECAM-1.

1997 • 669 citations

Molecular Regulation of Atrioventricular Valvuloseptal Morphogenesis

1995 • 642 citations

Involvement of endothelial PECAM-1/CD31 in angiogenesis.

1997 • 539 citations

Embryonic stem cells differentiate in vitro to endothelial cells through successive maturation steps

1996 • 479 citations

Involvement of Platelet-Endothelial Cell Adhesion Molecule-1 in Neutrophil Recruitment in Vivo

1993 • 468 citations

EndoCAM: a novel endothelial cell-cell adhesion molecule.

1990 • 409 citations

CD31 expressed on distinctive T cell subsets is a preferential amplifier of beta 1 integrin-mediated adhesion.

1992 • 383 citations

CD31/PECAM-1 is a ligand for alpha v beta 3 integrin involved in adhesion of leukocytes to endothelium.

1995 • 367 citations

A human endothelial cell-restricted, externally disposed plasmalemmal protein enriched in intercellular junctions.

1989 • 365 citations

Molecular cloning and expression of murine vascular endothelial- cadherin in early stage development of cardiovascular system

1996 • 325 citations

Molecular and functional aspects of PECAM-1/CD31

1994 • 325 citations

Platelet endothelial cell adhesion molecule-1 (PECAM-1 / CD31): alternatively spliced, functionally distinct isoforms expressed during mammalian cardiovascular development

1994 • 301 citations

Monoclonal antibody to murine PECAM-1 (CD31) blocks acute inflammation in vivo.

1994 • 296 citations

Migration of monocytes across endothelium and passage through extracellular matrix involve separate molecular domains of PECAM-1.

1995 • 240 citations

Molecular characterization and functional analysis of the leukocyte surface protein CD31.

1990 • 217 citations

The Protein-tyrosine Phosphatase SHP-2 Binds Platelet/Endothelial Cell Adhesion Molecule-1 (PECAM-1) and Forms a Distinct Signaling Complex during Platelet Aggregation

1997 • 215 citations

Endothelial cell tube formation depends on cadherin 5 and CD31 interactions with filamentous actin.

1997 • 209 citations

An anti-platelet-endothelial cell adhesion molecule-1 antibody inhibits leukocyte extravasation from mesenteric microvessels in vivo by blocking the passage through the basement membrane.

1996 • 198 citations

Identification of αvβ3 as a heterotypic ligand for CD31/PECAM-1

1996 • 197 citations

Soluble Domain 1 of Platelet–Endothelial Cell Adhesion Molecule (PECAM) Is Sufficient to Block Transendothelial Migration In Vitro and In Vivo

1997 • 184 citations

Platelet/endothelial cell adhesion molecule-1 (CD31)-mediated cellular aggregation involves cell surface glycosaminoglycans

1993 • 180 citations

Roles of platelet/endothelial cell adhesion molecule-1 (PECAM-1, CD31) in natural killer cell transendothelial migration and beta 2 integrin activation.

1996 • 180 citations

Individually Distinct Ig Homology Domains in PECAM-1 Regulate Homophilic Binding and Modulate Receptor Affinity

1996 • 174 citations

Ligation of platelet/endothelial cell adhesion molecule 1 (PECAM-1/CD31) on monocytes and neutrophils increases binding capacity of leukocyte CR3 (CD11b/CD18).

1995 • 169 citations

Molecular cloning of CD31, a putative intercellular adhesion molecule closely related to carcinoembryonic antigen.

1990 • 166 citations

Signals from platelet/endothelial cell adhesion molecule enhance the adhesive activity of the very late antigen-4 integrin of human CD34+ hemopoietic progenitor cells.

1994 • 166 citations

The heparin binding PECAM-1 adhesion molecule is expressed by CD34+ hematopoietic precursor cells with early myeloid and B-lymphoid cell phenotypes

1993 • 164 citations

PECAM-1: Its Expression and Function as a Cell Adhesion Molecule on Hemopoietic and Endothelial Cells

1995 • 152 citations

The Role of PECAM‐1 in Vascular Cell Biology^a

1994 • 148 citations

Platelet Endothelial Cell Adhesion Molecule-1 (PECAM-1) Homophilic Adhesion Is Mediated by Immunoglobulin-like Domains 1 and 2 and Depends on the Cytoplasmic Domain and the Level of Surface Expression

1996 • 142 citations

Polymorphism of Adhesion Molecule CD31 and Its Role in Acute Graft-Versus-Host Disease

1996 • 139 citations

Activation-dependent changes in human platelet PECAM-1: phosphorylation, cytoskeletal association, and surface membrane redistribution.

1992 • 137 citations

Vascular endothelial cells synthesize a plasma membrane protein indistinguishable from the platelet membrane glycoprotein IIa.

1985 • 132 citations

Early embryonic vascular development

1996 • 132 citations

Interferon gamma regulates platelet endothelial cell adhesion molecule 1 expression and neutrophil infiltration into herpes simplex virus-infected mouse corneas.

1996 • 132 citations

Murine platelet endothelial cell adhesion molecule (PECAM‐1)/CD31 modulates β₂ integrins on lymphokine‐activated killer cells

1993 • 131 citations

Biochemistry and expression of myelomonocytic antigens.

1986 • 129 citations

Human CD38 ligand. A 120-KDA protein predominantly expressed on endothelial cells.

1996 • 121 citations

Biosynthesis and processing of the cell adhesion molecule PECAM-1 includes production of a soluble form.

1994 • 113 citations

Blockade of platelet endothelial cell adhesion molecule-1 protects against myocardial ischemia and reperfusion injury in cats.

1996 • 110 citations

Mapping the homotypic binding sites in CD31 and the role of CD31 adhesion in the formation of interendothelial cell contacts.

1995 • 110 citations

Human CD38 ligand. A 120-KDA protein predominantly expressed on endothelial cells.

1996 • 106 citations

Neutrophil platelet endothelial cell adhesion molecule-1 participates in neutrophil recruitment at inflammatory sites and is down-regulated after leukocyte extravasation.

1997 • 103 citations

Integrin engagement mediates tyrosine dephosphorylation on platelet-endothelial cell adhesion molecule 1.

1996 • 102 citations

Deletions in the cytoplasmic domain of platelet-endothelial cell adhesion molecule-1 (PECAM-1, CD31) result in changes in ligand binding properties

1994 • 100 citations

A novel leukocyte differentiation antigen: two monoclonal antibodies TM2 and TM3 define a 120-kd molecule present on neutrophils, monocytes, platelets, and activated lymphoblasts

1985 • 96 citations

Characterization of the Human Platelet/Endothelial Cell Adhesion Molecule-1 Promoter: Identification of a GATA-2 Binding Element Required for Optimal Transcriptional Activity

1997 • 94 citations

The cell adhesion molecule CD31 is phosphorylated after cell activation. Down-regulation of CD31 in activated T lymphocytes.

1992 • 93 citations

Antibody to Platelet/Endothelial Cell Adhesion Molecule-1 Reduces Myocardial Infarct Size in a Rat Model of Ischemia-Reperfusion Injury

1996 • 90 citations

CD31/PECAM‐1‐driven chemokine‐independent transmigration of human T lymphocytes

1996 • 90 citations

Molecular cloning and adhesive properties of murine platelet/endothelial cell adhesion molecule 1.

1993 • 90 citations

Organization of the gene for human platelet/endothelial cell adhesion molecule-1 shows alternatively spliced isoforms and a functionally complex cytoplasmic domain

1994 • 87 citations

Identification of PECAM-1 in solid tumor cells and its potential involvement in tumor cell adhesion to endothelium.

1993 • 86 citations

Alternative Splicing of a Specific Cytoplasmic Exon Alters the Binding Characteristics of Murine Platelet/Endothelial Cell Adhesion Molecule-1 (PECAM-1)

1995 • 85 citations

Engagement of human PECAM-1 (CD31) on human endothelial cells increases intracellular calcium ion concentration and stimulates prostacyclin release.

1998 • 81 citations

Interaction of CD31 with a heterophilic counterreceptor involved in downregulation of human T cell responses.

1996 • 77 citations

Association of murine CD31 with transmigrating lymphocytes following antigenic stimulation.

1992 • 74 citations

CD31, a novel cell surface marker for CD4 cells of suppressor lineage, unaltered by state of activation.

1992 • 71 citations

Platelet-endothelial cell adhesion molecule-1 (PECAM-1/CD31) tyrosine phosphorylation state changes during vasculogenesis in the murine conceptus.

1997 • 66 citations

Cloning of the human platelet endothelial cell adhesion molecule-1 promoter and its tissue-specific expression. Structural and functional characterization.

1996 • 63 citations

Polymorphism of adhesion molecule CD31 is not a significant risk factor for graft-versus-host disease

1996 • 54 citations

The Human PECAM1 Gene Maps to 17q23

1996 • 54 citations

Phenotype of human T cells expressing CD31, a molecule of the immunoglobulin supergene family.

1992 • 53 citations

Identification of αvβ3 as a heterotypic ligand for CD31/PECAM-1

1996 • 52 citations

Tyrosine Residue in Exon 14 of the Cytoplasmic Domain of Platelet Endothelial Cell Adhesion Molecule-1 (PECAM-1/CD31) Regulates Ligand Binding Specificity

1997 • 45 citations

Involvement of CD31 in lymphocyte-mediated immune responses: importance of the membrane-proximal immunoglobulin domain and identification of an inhibiting CD31 peptide

1995 • 38 citations

Tyrosine phosphorylation of P-selectin in intact platelets and in a disulphide-linked complex with immunoprecipitated pp60c-src

1994 • 36 citations

Functional regulation of platelet/endothelial cell adhesion molecule-1 by TGF-beta 1 in promonocytic U-937 cells.

1994 • 33 citations

Different epitopes of the CD31 antigen identified by monoclonal antibodies: cell type‐specific patterns of expression

1991 • 25 citations

CD31 (PECAM-1), CDw32 (Fc gamma RII), and anti-HLA class I monoclonal antibodies recognize phosphotyrosine-containing proteins on the surface of human neutrophils.

1994 • 21 citations