Rab GTPases, intracellular traffic and disease

Rab proteins as membrane organizers

2001 • 3,320 citations

Small GTP-Binding Proteins

2001 • 2,449 citations

Identification of genes differentially regulated by interferon α, β, or γ using oligonucleotide arrays

1998 • 1,781 citations

Cloning and molecular characterization of genes whose products allow Salmonella typhimurium to penetrate tissue culture cells.

1989 • 988 citations

Mutations in RAB27A cause Griscelli syndrome associated with haemophagocytic syndrome

2000 • 935 citations

Evolution of the rab family of small GTP-binding proteins

2001 • 749 citations

A genomic perspective on membrane compartment organization

2001 • 693 citations

The Rab GTPase family.

2001 • 682 citations

Rab 7: an important regulator of late endocytic membrane traffic.

1995 • 625 citations

Arrest of Mycobacterial Phagosome Maturation Is Caused by a Block in Vesicle Fusion between Stages Controlled by rab5 and rab7

1997 • 556 citations

Novel myosin heavy chain encoded by murine dilute coat colour locus

1991 • 534 citations

Role of phosphatidylinositol 3-kinase and Rab5 effectors in phagosomal biogenesis and mycobacterial phagosome maturation arrest

2001 • 532 citations

Rab5 regulates motility of early endosomes on microtubules

1999 • 504 citations

Griscelli disease maps to chromosome 15q21 and is associated with mutations in the Myosin-Va gene

1997 • 448 citations

The mammalian Rab family of small GTPases: definition of family and subfamily sequence motifs suggests a mechanism for functional specificity in the Ras superfamily 1 1Edited by M. Yaniv

2000 • 446 citations

The melanosome: membrane dynamics in black and white

2001 • 441 citations

Rab27a Is Required for Regulated Secretion in Cytotoxic T Lymphocytes

2001 • 415 citations

A mutation in Rab27a causes the vesicle transport defects observed in ashen mice

2000 • 402 citations

Endocytosis and Signaling

2001 • 377 citations

Rab23 is an essential negative regulator of the mouse Sonic hedgehog signalling pathway

2001 • 368 citations

The Tuberous Sclerosis 2 Gene Product, Tuberin, Functions as a Rab5 GTPase Activating Protein (GAP) in Modulating Endocytosis

1997 • 353 citations

Biogenesis of Salmonella typhimurium-containing vacuoles in epithelial cells involves interactions with the early endocytic pathway

1999 • 328 citations

Mutations in GDI1 are responsible for X-linked non-specific mental retardation

1998 • 327 citations

Rab27a Regulates the Peripheral Distribution of Melanosomes in Melanocytes

2001 • 326 citations

Sec2p Mediates Nucleotide Exchange on Sec4p and Is Involved in Polarized Delivery of Post-Golgi Vesicles

1997 • 318 citations

Purification and characterization from bovine brain cytosol of a protein that inhibits the dissociation of GDP from and the subsequent binding of GTP to smg p25A, a ras p21-like GTP-binding protein.

1990 • 305 citations

Ypt and Rab GTPases: insight into functions through novel interactions

2001 • 291 citations

The Eps8 protein coordinates EGF receptor signalling through Rac and trafficking through Rab5

2000 • 288 citations

Traffic Jam: A Compendium of Human Diseases that Affect Intracellular Transport Processes

2000 • 280 citations

Mutations in Mlph , encoding a member of the Rab effector family, cause the melanosome transport defects observed in leaden mice

2001 • 249 citations

The Cooh-Terminal Domain of Myo2p, a Yeast Myosin V, Has a Direct Role in Secretory Vesicle Targeting

1999 • 247 citations

Defective Granule Exocytosis in Rab27a-Deficient Lymphocytes from Ashen Mice

2001 • 245 citations

Controlling the maturation of pathogen-containing vacuoles: a matter of life and death

1999 • 241 citations

Retinitis Pigmentosa

1987 • 236 citations

The rab7 GTPase controls the maturation of Salmonella typhimurium-containing vacuoles in HeLa cells

1999 • 234 citations

Epidermal Growth Factor and Membrane Trafficking

2000 • 233 citations

Local Calcium Release in Dendritic Spines Required for Long-Term Synaptic Depression

2000 • 232 citations

Rab escort protein-1 is a multifunctional protein that accompanies newly prenylated rab proteins to their target membranes.

1994 • 230 citations

Rab27a enables myosin Va-dependent melanosome capture by recruiting the myosin to the organelle

2001 • 222 citations

Partial albinism with immunodeficiency (Griscelli syndrome)

1994 • 221 citations

Role of Rab GTPases in Membrane Traffic

1997 • 217 citations

Deficient Geranylgeranylation of Ram/Rab27 in Choroideremia

1995 • 215 citations

Rab27a

2001 • 208 citations

Mouse Models of Hermansky Pudlak Syndrome: A Review

1998 • 192 citations

Prenylation of Rab GTPases: molecular mechanisms and involvement in genetic disease

2001 • 178 citations

Impaired recruitment of the small GTPase rab7 correlates with the inhibition of phagosome maturation by Leishmania donovani promastigotes

1999 • 161 citations

Rab geranylgeranyl transferase α mutation in the gunmetal mouse reduces Rab prenylation and platelet synthesis

2000 • 158 citations

Pathogenic trickery: deception of host cell processes

2001 • 157 citations

The dilute-lethal (d) gene attacks a Ca2+ store in the dendritic spine of Purkinje cells in mice

1996 • 147 citations

Hermansky–Pudlak Syndrome and Related Disorders of Organelle Formation

2000 • 147 citations

Alternative Splicing of the HumanRab6AGene Generates Two Close but Functionally Different Isoforms

2000 • 109 citations

Organization of the Rab‐GDI/CHM Superfamily: The Functional Basis for Choroideremia Disease

2001 • 104 citations

Evaluation of retinal photoreceptors and pigment epithelium in a female carrier of choroideremia

2001 • 100 citations

Redirection of Host Vesicle Trafficking Pathways by Intracellular Parasites

2000 • 94 citations

Increased Expression of Rab5a Correlates Directly with Accelerated Maturation of Listeria monocytogenesPhagosomes

1999 • 85 citations

SopE Acts as an Rab5-specific Nucleotide Exchange Factor and Recruits Non-prenylated Rab5 on Salmonella-containing Phagosomes to Promote Fusion with Early Endosomes

2001 • 78 citations

Role of Rab GDP dissociation inhibitor α in regulating plasticity of hippocampal neurotransmission

2000 • 76 citations

Genetic Defects of Intracellular-Membrane Transport

2000 • 74 citations

Interferon-γ Selectively Induces Rab5a Synthesis and Processing in Mononuclear Cells

1998 • 67 citations

New insights into the pathogenesis of choroideremia: a tale of two REPs

1996 • 60 citations

Inherited thrombocytopenia caused by reduced platelet production in mice with the gunmetal pigment gene mutation

1995 • 59 citations

Interferon-γ Listericidal Action Is Mediated by Novel Rab5a Functions at the Phagosomal Environment

2001 • 52 citations

PIGMENT DILUTION AND IMMUNODEFICIENCY: A NEW SYNDROME

1978 • 42 citations

9. Retinitis Pigmentosa

1981 • 34 citations

Expression of constitutively active Rab5 uncouples maturation of the Salmonella-containing vacuole from intracellular replication

2001 • 20 citations

Purification and Characterization of Rab GDIβ from Rat Brain

1995 • 8 citations