High-Resolution Crystal Structure of an Engineered Human β ₂ -Adrenergic G Protein–Coupled Receptor

The PyMOL Molecular Graphics System

2002 • 18,218 citations

Electrostatics of nanosystems: Application to microtubules and the ribosome

2001 • 7,053 citations

Crystal Structure of Rhodopsin: A G Protein-Coupled Receptor

2000 • 5,539 citations

The G-Protein-Coupled Receptors in the Human Genome Form Five Main Families. Phylogenetic Analysis, Paralogon Groups, and Fingerprints

2003 • 2,754 citations

Drug Discovery: A Historical Perspective

2000 • 2,654 citations

Seven-transmembrane receptors

2002 • 2,571 citations

Crystal structure of the human β2 adrenergic G-protein-coupled receptor

2007 • 1,885 citations

Transduction of Receptor Signals by ß-Arrestins

2005 • 1,656 citations

GPCR Engineering Yields High-Resolution Structural Insights into β ₂ -Adrenergic Receptor Function

2007 • 1,322 citations

G Protein-coupled Receptors

1998 • 1,292 citations

Uncovering Molecular Mechanisms Involved in Activation of G Protein-Coupled Receptors

2000 • 1,199 citations

OPM: Orientations of Proteins in Membranes database

2006 • 1,121 citations

The Retinal Conformation and its Environment in Rhodopsin in Light of a New 2.2 Å Crystal Structure

2004 • 1,025 citations

Lipidic cubic phases: A novel concept for the crystallization of membrane proteins

1996 • 968 citations

A Peptide Derived from a β2-Adrenergic Receptor Transmembrane Domain Inhibits Both Receptor Dimerization and Activation

1996 • 758 citations

G Protein–Coupled Receptor Rhodopsin

2006 • 737 citations

Structure of Bovine Rhodopsin in a Trigonal Crystal Form

2004 • 718 citations

Conformational complexity of G-protein-coupled receptors

2007 • 675 citations

A monomeric G protein-coupled receptor isolated in a high-density lipoprotein particle efficiently activates its G protein

2007 • 661 citations

Nobel lecture. The photosynthetic reaction centre from the purple bacterium Rhodopseudomonas viridis.

1989 • 634 citations

Detection of β ₂ -adrenergic receptor dimerization in living cells using bioluminescence resonance energy transfer (BRET)

2000 • 631 citations

Palmitoylation of the human β2-adrenergic receptor

1989 • 599 citations

Conserved aspartic acid residues 79 and 113 of the beta-adrenergic receptor have different roles in receptor function.

1988 • 533 citations

Identification of Two Serine Residues Involved in Agonist Activation of the β-Adrenergic Receptor

1989 • 522 citations

G Protein-Coupled Receptor Dimerization: Function and Ligand Pharmacology

2004 • 467 citations

Quantitative Assessment of β1- and β2-Adrenergic Receptor Homo- and Heterodimerization by Bioluminescence Resonance Energy Transfer

2002 • 466 citations

Crystal structure of a photoactivated deprotonated intermediate of rhodopsin

2006 • 439 citations

β2 Adrenergic Receptor Activation

2002 • 405 citations

MOLECULAR MECHANISM OF 7TM RECEPTOR ACTIVATION—A GLOBAL TOGGLE SWITCH MODEL

2006 • 397 citations

The evolving role of lipid rafts and caveolae in G protein‐coupled receptor signaling: implications for molecular pharmacology

2004 • 394 citations

Identification of G protein‐coupled receptor genes from the human genome sequence

2002 • 355 citations

Adrenergic Receptors as Models for G Protein-Coupled Receptors

1992 • 340 citations

Protein‐based virtual screening of chemical databases. II. Are homology models of g‐protein coupled receptors suitable targets?

2002 • 295 citations

The Fourth Transmembrane Segment Forms the Interface of the Dopamine D2 Receptor Homodimer

2003 • 285 citations

Room to Move: Crystallizing Membrane Proteins in Swollen Lipidic Mesophases

2006 • 267 citations

Caveolar Localization Dictates Physiologic Signaling of β2-Adrenoceptors in Neonatal Cardiac Myocytes

2002 • 236 citations

The evolution of transmembrane helix kinks and the structural diversity of G protein-coupled receptors

2004 • 234 citations

Structure Modeling of All Identified G Protein–Coupled Receptors in the Human Genome

2006 • 232 citations

The superfamily of heptahelical receptors

2000 • 228 citations

Structure, function, and regulation of adrenergic receptors

1993 • 224 citations

The Forgotten Serine

2000 • 186 citations

Seven-Transmembrane Receptor Signaling Through β-Arrestin

2005 • 183 citations

A lipid’s eye view of membrane protein crystallization in mesophases

2000 • 178 citations

A robotic system for crystallizing membrane and soluble proteins in lipidic mesophases

2004 • 147 citations

Predicted 3D structure for the human β2 adrenergic receptor and its binding site for agonists and antagonists

2004 • 123 citations

The high affinity state of the beta 2-adrenergic receptor requires unique interaction between conserved and non-conserved extracellular loop cysteines.

1994 • 123 citations

Dosage-dependent switch from G protein-coupled to G protein-independent signaling by a GPCR

2006 • 112 citations

Pharmacogenetics of the human beta-adrenergic receptors

2006 • 105 citations

Molecular mechanism for the crystallization of bacteriorhodopsin in lipidic cubic phases

2001 • 103 citations

The Ants Go Marching Two by Two: Oligomeric Structure of G-Protein-Coupled Receptors

2004 • 97 citations

In Meso Structure of the Cobalamin Transporter, BtuB, at 1.95 Å Resolution

2006 • 95 citations

Homology Modeling of the Serotonin 5-HT_1A Receptor Using Automated Docking of Bioactive Compounds with Defined Geometry

2005 • 93 citations

Structure of rhodopsin and the metarhodopsin I photointermediate

2005 • 87 citations

Catecholamine Receptors: Structure, Function, and Regulation

1993 • 83 citations

Toward the active conformations of rhodopsin and the β₂‐adrenergic receptor

2004 • 75 citations

Using synthetic lipids to stabilize purified β2 adrenoceptor in detergent micelles

2005 • 67 citations

β-adrenoceptors on smooth muscle, nerves and inflammatory cells

1993 • 64 citations

Beta2 adrenergic receptors in asthma: A current perspective

1992 • 55 citations

Three-Dimensional Models for β-Adrenergic Receptor Complexes with Agonists and Antagonists

2003 • 53 citations

Why are there so many adrenoceptor subtypes?

1994 • 50 citations

A Primate-dominant Third Glycosylation Site of the β2-Adrenergic Receptor Routes Receptors to Degradation during Agonist Regulation

2004 • 45 citations

Physiological consequences of β-adrenergic receptor disruption

1998 • 45 citations

Structural studies of the putative helix 8 in the human β2 adrenergic receptor: an NMR study

2004 • 39 citations

Adrenergic Receptors From Molecular Structure to in vivo function

1997 • 37 citations

Modeling the Structural Basis of Human CCR5 Chemokine Receptor Function: From Homology Model Building and Molecular Dynamics Validation to Agonist and Antagonist Docking

2006 • 35 citations

Do receptors get pregnant too? Adrenergic receptor alterations in human pregnancy

1996 • 34 citations

The adrenergic receptors : in the 21st century

2006 • 30 citations

Structural and mechanistic insight from high resolution structures of archaeal rhodopsins

2003 • 22 citations

Computational Elucidation of the Structural Basis of Ligand Binding to the Dopamine 3 Receptor through Docking and Homology Modeling

2006 • 22 citations