Palmitoylation is required for efficient Fas cell death signaling

Cytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins form a death-inducing signaling complex (DISC) with the receptor.

1995 • 2,142 citations

Fatty acylation of proteins: new insights into membrane targeting of myristoylated and palmitoylated proteins

1999 • 1,236 citations

Amyloidogenic processing of the Alzheimer β-amyloid precursor protein depends on lipid rafts

2003 • 1,058 citations

Differential Modulation of Apoptosis Sensitivity in CD95 Type I and Type II Cells

1999 • 595 citations

Palmitoylation of Intracellular Signaling Proteins: Regulation and Function

2004 • 579 citations

Compartmentalization of TNF Receptor 1 Signaling

2004 • 479 citations

Dynamic molecular confinement in the plasma membrane by microdomains and the cytoskeleton meshwork

2006 • 468 citations

Fluorescence Correlation Spectroscopy Diffusion Laws to Probe the Submicron Cell Membrane Organization

2005 • 430 citations

Molecular Ordering of the Initial Signaling Events of CD95

2002 • 387 citations

CD95 ligand induces motility and invasiveness of apoptosis-resistant tumor cells

2004 • 287 citations

The antitumor ether lipid ET-18-OCH3 induces apoptosis through translocation and capping of Fas/CD95 into membrane rafts in human leukemic cells

2001 • 274 citations

Dynamics in the plasma membrane: how to combine fluidity and order

2006 • 274 citations

The role of receptor internalization in CD95 signaling

2006 • 234 citations

Ligand-independent redistribution of Fas (CD95) into lipid rafts mediates clonotypic T cell death

2004 • 233 citations

Vav1/Rac-dependent actin cytoskeleton reorganization is required for lipid raft clustering in T cells

2001 • 222 citations

An essential role for membrane rafts in the initiation of Fas/CD95‐triggered cell death in mouse thymocytes

2002 • 219 citations

CD95 (APO-1/Fas) linkage to the actin cytoskeleton through ezrin in human T lymphocytes: a novel regulatory mechanism of the CD95 apoptotic pathway

2000 • 217 citations

Lipid Rafts Unite Signaling Cascades with Clathrin to Regulate BCR Internalization

2002 • 216 citations

Intracellular Triggering of Fas Aggregation and Recruitment of Apoptotic Molecules into Fas-enriched Rafts in Selective Tumor Cell Apoptosis

2004 • 212 citations

Membrane Targeting of Lipid Modified Signal Transduction Proteins

2004 • 205 citations

Phosphoinositide kinase, diacylglycerol kinase, and phospholipase C activities associated to the cytoskeleton: effect of epidermal growth factor.

1991 • 202 citations

GENETIC DISORDERS OF PROGRAMMED CELL DEATH IN THE IMMUNE SYSTEM

2005 • 192 citations

Cytoskeleton-mediated Death Receptor and Ligand Concentration in Lipid Rafts Forms Apoptosis-promoting Clusters in Cancer Chemotherapy

2005 • 181 citations

Lipid domain formation and dynamics in giant unilamellar vesicles explored by fluorescence correlation spectroscopy

2003 • 177 citations

Caspase-dependent and -independent Activation of Acid Sphingomyelinase Signaling

2005 • 165 citations

Role of membrane sphingomyelin and ceramide in platform formation for Fas-mediated apoptosis

2005 • 150 citations

Relationships between EGFR Signaling–competent and Endocytosis-competent Membrane Microdomains

2005 • 144 citations

The death-inducing signalling complex is recruited to lipid rafts in Fas-induced apoptosis

2002 • 128 citations

Cytoskeleton-dependent Membrane Domain Segregation during Neutrophil Polarization

2001 • 125 citations

The extracellular domains of FasL and Fas are sufficient for the formation of supramolecular FasL-Fas clusters of high stability

2005 • 102 citations

Induction of apoptosis and activation of NF‐κB by CD95 require different signalling thresholds

2004 • 101 citations

CD95 death‐inducing signaling complex formation and internalization occur in lipid rafts of type I and type II cells

2004 • 99 citations

Fluorescence correlation spectroscopy of molecular motions and kinetics

2005 • 92 citations

DCC association with lipid rafts is required for netrin-1-mediated axon guidance

2005 • 81 citations

Integrin-dependent interaction of lipid rafts with the actin cytoskeleton in activated human platelets

2005 • 79 citations

Fas ligand is localized to membrane rafts, where it displays increased cell death–inducing activity

2005 • 78 citations

Caspase-3 Is a Component of Fas Death-Inducing Signaling Complex in Lipid Rafts and Its Activity Is Required for Complete Caspase-8 Activation during Fas-Mediated Cell Death

2004 • 71 citations

Identification of SNF1/AMP Kinase-related Kinase as an NF-κB-regulated Anti-apoptotic Kinase Involved in CD95-induced Motility and Invasiveness

2004 • 67 citations

Thy-1-mediated activation of rat mast cells: the role of Thy-1 membrane microdomains.

1996 • 65 citations

Actin dependent CD95 internalization is specific for Type I cells

2003 • 48 citations

Plasma Membrane Organization Is Essential for Balancing Competing Pseudopod- and Uropod-promoting Signals during Neutrophil Polarization and Migration

2005 • 44 citations

The role of FAS to ezrin association in FAS-mediated apoptosis

2005 • 44 citations

CD95/phosphorylated ezrin association underlies HIV-1 GP120/IL-2-induced susceptibility to CD95(APO-1/Fas)-mediated apoptosis of human resting CD4+T lymphocytes

2004 • 38 citations

The oxygen-substituted palmitic acid analogue, 13-oxypalmitic acid, inhibits Lck localization to lipid rafts and T cell signaling

2002 • 34 citations

The relevance of NF-?B for CD95 Signaling in Tumor Cells

2004 • 33 citations