Structural determinants for partitioning of lipids and proteins between coexisting fluid phases in giant plasma membrane vesicles

Functional rafts in cell membranes

1997 • 9,471 citations

Lipid rafts and signal transduction

2000 • 6,079 citations

Structure and Function of Sphingolipid- and Cholesterol-rich Membrane Rafts

2000 • 2,321 citations

Partitioning of Lipid-Modified Monomeric GFPs into Membrane Microdomains of Live Cells

2002 • 2,231 citations

Model Systems, Lipid Rafts, and Cell Membranes

2004 • 1,625 citations

The State of Lipid Rafts: From Model Membranes to Cells

2003 • 1,334 citations

Lipid Rafts Reconstituted in Model Membranes

2001 • 1,330 citations

Lipid Domain Structure of the Plasma Membrane Revealed by Patching of Membrane Components

1998 • 1,193 citations

Paradigm Shift of the Plasma Membrane Concept from the Two-Dimensional Continuum Fluid to the Partitioned Fluid: High-Speed Single-Molecule Tracking of Membrane Molecules

2005 • 1,086 citations

Sphingolipid–Cholesterol Rafts Diffuse as Small Entities in the Plasma Membrane of Mammalian Cells

2000 • 987 citations

Nanoscale Organization of Multiple GPI-Anchored Proteins in Living Cell Membranes

2004 • 865 citations

LAT Palmitoylation

1998 • 837 citations

Large-scale fluid/fluid phase separation of proteins and lipids in giant plasma membrane vesicles

2007 • 778 citations

Interactions between saturated acyl chains confer detergent resistance on lipids and glycosylphosphatidylinositol (GPI)-anchored proteins: GPI-anchored proteins in liposomes and cells show similar behavior.

1994 • 688 citations

Parallax method for direct measurement of membrane penetration depth utilizing fluorescence quenching by spin-labeled phospholipids

1987 • 671 citations

Engagement of T cell receptor triggers its recruitment to low-density detergent-insoluble membrane domains

1998 • 630 citations

Role of Lipid Modifications in Targeting Proteins to Detergent-resistant Membrane Rafts

1999 • 626 citations

Lipid Rafts and Caveolae as Portals for Endocytosis: New Insights and Common Mechanisms

2003 • 589 citations

A Microscopic Interaction Model of Maximum Solubility of Cholesterol in Lipid Bilayers

1999 • 585 citations

Role of cholesterol in lipid raft formation: lessons from lipid model systems

2003 • 566 citations

Triton Promotes Domain Formation in Lipid Raft Mixtures

2002 • 547 citations

PIP2 and PIP3

2000 • 538 citations

Detergent-resistant membranes should not be identified with membrane rafts

2005 • 483 citations

Location is Everything: Lipid Rafts and Immune Cell Signaling

2003 • 477 citations

Pathogens: raft hijackers

2003 • 471 citations

Dynamics of putative raft-associated proteins at the cell surface

2004 • 446 citations

Characterization of Cholesterol-Sphingomyelin Domains and Their Dynamics in Bilayer Membranes

2001 • 429 citations

Ceramide Selectively Displaces Cholesterol from Ordered Lipid Domains (Rafts)

2004 • 413 citations

Sterol structure determines the separation of phases and the curvature of the liquid-ordered phase in model membranes

2005 • 404 citations

Lysophospholipid receptors: Signalling, pharmacology and regulation by lysophospholipid metabolism

2006 • 367 citations

Lipid rafts and B-cell activation

2002 • 349 citations

Role of sphingomyelinase and ceramide in modulating rafts: do biophysical properties determine biologic outcome?

2002 • 338 citations

Partitioning of Thy-1, GM1, and cross-linked phospholipid analogs into lipid rafts reconstituted in supported model membrane monolayers

2001 • 329 citations

Crosslinking a lipid raft component triggers liquid ordered-liquid disordered phase separation in model plasma membranes

2005 • 314 citations

Scaffolding microdomains and beyond: the function of reggie/flotillin proteins

2005 • 311 citations

Lipid Rafts and the Regulation of Exocytosis

2004 • 291 citations

Fc epsilon RI-mediated recruitment of p53/56lyn to detergent-resistant membrane domains accompanies cellular signaling.

1995 • 290 citations

NEW EMBO MEMBERS' REVIEW: Actin cytoskeleton regulation through modulation of PI(4,5)P2 rafts

2001 • 289 citations

Quantitative Analysis of Phospholipids in Functionally Important Membrane Domains from RBL-2H3 Mast Cells Using Tandem High-Resolution Mass Spectrometry

1999 • 288 citations

Cholesterol depletion induces large scale domain segregation in living cell membranes

2001 • 287 citations

Plasma Membrane Vesiculation: A New Technique for Isolation of Plasma Membranes

1976 • 261 citations

ROLES OF BILAYER MATERIAL PROPERTIES IN FUNCTION AND DISTRIBUTION OF MEMBRANE PROTEINS

2006 • 224 citations

Glycosylphosphatidyl Inositol-anchored Proteins and fyn Kinase Assemble in Noncaveolar Plasma Membrane Microdomains Defined by Reggie-1 and -2

2001 • 223 citations

Cytoskeletal regulation: rich in lipids

2004 • 220 citations

PIP2 signaling in lipid domains: a critical re-evaluation

2005 • 183 citations

Structure-Function Analysis of Lyn Kinase Association with Lipid Rafts and Initiation of Early Signaling Events after Fcɛ Receptor I Aggregation

2001 • 175 citations

Simulation of the Early Stages of Nano-Domain Formation in Mixed Bilayers of Sphingomyelin, Cholesterol, and Dioleylphosphatidylcholine

2004 • 168 citations

Alkyl-lysophospholipid Accumulates in Lipid Rafts and Induces Apoptosis via Raft-dependent Endocytosis and Inhibition of Phosphatidylcholine Synthesis

2002 • 165 citations

The Sensitivity of Lipid Domains to Small Perturbations Demonstrated by the Effect of Triton

2003 • 164 citations

Raft Partitioning and Dynamic Behavior of Human Placental Alkaline Phosphatase in Giant Unilamellar Vesicles

2005 • 163 citations

Fluorescence Anisotropy Measurements of Lipid Order in Plasma Membranes and Lipid Rafts from RBL-2H3 Mast Cells

2001 • 152 citations

Large-scale co-aggregation of fluorescent lipid probes with cell surface proteins.

1994 • 146 citations

Lipid rafts in T cell receptor signalling (Review)

2006 • 142 citations

Lipid segregation and IgE receptor signaling: A decade of progress

2005 • 136 citations

Palmitoylation and Intracellular Domain Interactions Both Contribute to Raft Targeting of Linker for Activation of T Cells

2005 • 126 citations

Do lipid rafts mediate virus assembly and pseudotyping?

2003 • 122 citations

Cholesterol-Induced Protein Sorting: An Analysis of Energetic Feasibility

2003 • 120 citations

Temporally resolved interactions between antigen-stimulated IgE receptors and Lyn kinase on living cells

2005 • 118 citations

Electron Spin Resonance Characterization of Liquid Ordered Phase of Detergent-Resistant Membranes from RBL-2H3 Cells

1999 • 116 citations

Compartmentalization of Phosphatidylinositol 4,5-Bisphosphate in Low-Density Membrane Domains in the Absence of Caveolin

1998 • 107 citations

Sphingolipid Partitioning into Ordered Domains in Cholesterol-Free and Cholesterol-Containing Lipid Bilayers

2003 • 107 citations

The N-terminal Region of the Prion Protein Ectodomain Contains a Lipid Raft Targeting Determinant

2003 • 98 citations

Interaction of ceramides with phosphatidylcholine, sphingomyelin and sphingomyelin/cholesterol bilayers

2001 • 98 citations

Partitioning of membrane molecules between raft and non-raft domains: Insights from model-membrane studies

2005 • 90 citations

Lipid rafts in lymphocyte activation and migration (Review)

2006 • 84 citations

Phase Diagram of a Ternary Mixture of Cholesterol and Saturated and Unsaturated Lipids Calculated from a Microscopic Model

2006 • 78 citations

Fluorescence Resonance Energy Transfer between Lipid Probes Detects Nanoscopic Heterogeneity in the Plasma Membrane of Live Cells

2007 • 78 citations

Fc epsilon RI-mediated association of 6-micron beads with RBL-2H3 mast cells results in exclusion of signaling proteins from the forming phagosome and abrogation of normal downstream signaling.

1996 • 77 citations

Reconstitution of Regulated Phosphorylation of FcϵRI by a Lipid Raft-excluded Protein-tyrosine Phosphatase

2004 • 68 citations

Partitioning of Pyrene-Labeled Phospho- and Sphingolipids between Ordered and Disordered Bilayer Domains

2004 • 43 citations

Solubility of amphiphiles in membranes: influence of phase properties and amphiphile head group

2002 • 26 citations